| DC21350 |
MS4077 |
MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM). |
|
| DC21351 |
MS4078
Featured
|
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM). |
|
| DC7682 |
MS417
Featured
|
MS417 is a novel BrD inhibitor with high affinity and specificity For the BrDs of BET proteins. pIC50 7.52 (IC50 30 nM). |
|
| DC7620 |
MS436
Featured
|
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. |
|
| DC11063 |
MS645 |
MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2. |
|
| DC23316 |
MS7972 |
MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association. |
|
| DC20466 |
MsbA inhibitor 1
Featured
|
MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC o |
|
| DC21352 |
MSC 1094308 |
MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively. |
|
| DC22166 |
MSC2504877
Featured
|
MSC2504877 (MSC-2504877) a novel small molecule selective tankyrase inhibitor with IC50 of 0.7/0.8 nM against TNKS1/2, shows 771-fold selectivity for TNKS1 over PARP1 (IC50=0.54 uM). |
|
| DC10627 |
MSC2530818
Featured
|
MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. |
|
| DC10894 |
MSDC-0602
Featured
|
MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes. |
|
| DC21353 |
MSN-125 |
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM. |
|
| DC11310 |
MST312
Featured
|
MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). |
|
| DC8822 |
MSX-122
Featured
|
MSX-122 is a n orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. |
|
| DC11270 |
MSX-130
Featured
|
MSX-130 is CXCR4 Antagonist. |
|
| DC10023 |
MT-1
Featured
|
MT1 is a bivalent chemical probe of BET bromodomains.MT1 is an intramolecular bivalent BRD4 binder that is more than 100-fold more potent, in cellular assays, than the corresponding monovalent antagonist, JQ1. |
|
| DC22167 |
MT-802
Featured
|
MT-802 (MT802) is a potent BTK PROTAC that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM). |
|
| DC20061 |
MtbHU-IN-1 |
MtbHU-IN-1 is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with a Kd of 98 nM for binding to WT MtbHU. |
|
| DC10332 |
Methylthio-DADMe-Immucillin A; MTDIA
Featured
|
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM. |
|
| DC9507 |
MTEP (hydrochloride) |
MTEP Hcl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. |
|
| DC22139 |
MTI-31
Featured
|
MTI31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G. |
|
| DC20230 |
mTOR inhibitor-1
Featured
|
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. |
|
| DC20468 |
Mtphagy Dye |
Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy. |
|
| DC8240 |
3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium
Featured
|
MTS is water-soluble and used in the MTS assay. |
|
| DC10871 |
MTX211
Featured
|
MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. |
|
| DC22168 |
MU1210 |
MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1). |
|
| DC22169 |
MU1300 |
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly. |
|
| DC7205 |
Mubritinib (TAK 165)
Featured
|
Mubritinib is a potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase. |
|
| DC12212 |
Mulberrin (Kuwanon C) |
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM. |
|
| DC11273 |
Murepavadin (POL7080)
Featured
|
Murepavadin is a novel class of highly specific outer membrane protein targeting antibiotic to treat resistant Pseudomonas infections. |
|
