| DC10159 |
N3-PEG3-vc-PAB-MMAE
Featured
|
N3-PEG3-vc-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the peptide N3-PEG3-vc-PAB. |
|
| DC9543 |
N3PT |
N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TK) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo.
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|
| DC10154 |
N6-(2-Phenylethyl)adenosine |
N6-(2-Phenylethyl)adenosine is a selective A1 adenosine receptor agonist. |
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| DC7471 |
N6022
Featured
|
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor(IC50=10 nM) which is currently undergoing clinical development. |
|
| DC23617 |
NAB-14
Featured
|
NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons. |
|
| DC8980 |
Nabumetone |
Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. |
|
| DC21358 |
N-acetyl lysyltyrosylcysteine amide
Featured
|
N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation. |
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| DC23924 |
N-Acetyl-Calicheamicin
Featured
|
N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic. |
|
| DC20470 |
NAcM-COV |
NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays. |
|
| DC20038 |
NAcM-OPT
Featured
|
NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction. |
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| DC21444 |
Nacubactam
Featured
|
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial. |
|
| DC9619 |
Nafamostat (mesylate)
Featured
|
Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant,showed highly potent activity against COVID-19(SARS-COV-2).
|
|
| DCAPI1550 |
Naftopidil |
Naftopidil is an α-1-Adrenergic receptor antagonist and an antihypertensive. |
|
| DC23132 |
Nalfurafine hydrochloride
Featured
|
Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively). |
|
| DC23102 |
Nalfurafine
Featured
|
Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively). |
|
| DCAPI1173 |
Nalidixic acid (NegGram) |
Nalidixic acid (NegGram) |
|
| DC20016 |
Naloxegol
Featured
|
Naloxegol is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation. |
|
| DC8492 |
Naloxegol Oxalate(NKTR-118)
Featured
|
Naloxegol is the first oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation. |
|
| DC8407 |
Naloxone HCl Dihydrate
Featured
|
Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose. |
|
| DC9787 |
NAMI-A |
NAMI-A is a ruthenium anticancer agent and a metastasis inhibitor. |
|
| DC20031 |
NAMPT inhibitor-linker 1 |
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin |
|
| DC20032 |
NAMPT inhibitor-linker 2 |
NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin |
|
| DC22632 |
NAN-190 hydrobromide |
NAN-190 is a 5-HT1A receptor antagonist with Ki of 0.6 nM. |
|
| DCAPI1293 |
Nanchangmycin |
Nanchangmycin (dianemycin) is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for for mammals and plants. |
|
| DC10266 |
Nandrolone decanoate
Featured
|
Nandrolone Decanoate is a mild form of an anabolic steroid. |
|
| DC10228 |
Nandrolone |
Nandrolone is a synthetic, anabolic steroid analog of testosterone. |
|
| DC8474 |
Napabucasin (BBI608)
Featured
|
Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. |
|
| DCAPI1368 |
Naphyrone (O-2482) |
Naphyrone (O-2482) |
|
| DC9000 |
Naproxen sodium |
Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
|
| DC8982 |
Naproxen |
Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
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