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Zotatifin

  Cat. No.:  DC40155   Featured
Chemical Structure
2098191-53-6
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More than 5000 active chemicals with high quality for research!
Field of application
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2098191-53-6
Chemical Name: Zotatifin
Synonyms: Zotatifin;2EWN8Z05CN;Zotatifin [INN];Benzonitrile, 4-((5aR,6S,7S,8R,8aS)-7-((dimethylamino)methyl)-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)-;4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)benzonitrile;eFT226;HY-112163;HY-112163;4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl)benzonitrile;4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl)benzonitrile;NSC828584;NSC828584;4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile;Zotatifin [USAN];4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile;CS-0043584;Zotatifin [USAN];EFT226;rel-Zotatifin;CS-0043584;4-{(5aR,6S,7S,8R,8aS)-7-[(Dimethylamino)methyl]-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl}benzonitrile;EFT226;DTXSID001022536;D11837;rel-Zotatifin;WHO 10998;4-{(5aR,6S,7S,8R,8aS)-7-[(Dimethylamino)methyl]-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl}benzonitrile;Zotatifin [USAN:INN];DTXSID001022536;NSC-818001;D11837;ZOTATIFIN [WHO-DD];WHO 10998;SCHEMBL18864788;Zotatifin [USAN:INN];4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.0,dodeca-1(12),8,10-trien-6-yl]benzonitrile;EFT-226;NSC-818001;UNII-2EWN8Z05CN;ZOTATIFIN [WHO-DD];2098191-54-7;SCHEMBL18864788;Zotafin;AKOS040742848;4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.0,dodeca-1(12),8,10-trien-6-yl]benzonitrile;BDBM50540861;EFT-226;MS-29059;EX-A4623;UNII-2EWN8Z05CN;G17541;2098191-54-7;G17581;Zotafin;NSC818001;AKOS040742848;CHEMBL4303782;BDBM50540861;2098191-53-6;MS-29059;NSC-828584;EX-A4623;Zotatifin (USAN/INN);G17541;DA-79135;G17581;NSC818001;CHEMBL4303782;2098191-53-6;NSC-828584;Zotatifin (USAN/INN);DA-79135
SMILES: O1C2=C([H])C(=NC(=C2[C@@]2([C@@]([H])([C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C3C([H])=C([H])C([H])=C([H])C=3[H])[C@]12C1C([H])=C([H])C(C#N)=C([H])C=1[H])O[H])O[H])OC([H])([H])[H])OC([H])([H])[H]
Formula: C28H29N3O5
M.Wt: 487.5470
Purity: >98%
Sotrage: 4°C, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70380 EGPI-1 EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.EGPI-1 has potent antiproliferative and proapoptotic activity in multiple myeloma cells, Jurkat cells, and A549 lung cancer cell lines, inhibts A549 proliferation with IC50 of 2.61 uM, which is better than that of 4EGI-1 (IC50=58.6 uM), inhibits cancer cell growth by inhibiting eIF4E phosphorylation and inhibiting PI3K/Akt/mTOR signal pathway.EGPI-1 induces autophagy, apoptosis, G0/G1 cell cycle arrest and ROS generation in A549 cells, disrupts the mitochondrial membrane potential (∆ψ m).EGPI-1 demonstrated in vivo anti-tumor activities in A549-xenografted athymic mice (25 mg/kg/day, 50 mg/kg/day, i.p.).
DC40155 Zotatifin Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.
DC10415 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
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