PF-06291874（glucagon receptor antagonists-4）

Cas No.:	1393124-08-7
Chemical Name:	Glucagon receptor antagonists-4
Synonyms:	glucagon receptor antagonists-4;N-[4-[(1S)-1-[3,5-Dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy]butyl]benzoyl]--alanine;PF-06291874;CGY4I8F278;(S)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoic acid;BDBM50433577;DB15065;PF06291874; Glucagon receptor antagonists-4;3-[[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acid;beta-Alanine, N-(4-((1S
SMILES:	FC(C1C([H])=NN(C=1[H])C1C(C([H])([H])[H])=C([H])C(=C([H])C=1C([H])([H])[H])O[C@]([H])(C1C([H])=C([H])C(C(N([H])C([H])([H])C([H])([H])C(=O)O[H])=O)=C([H])C=1[H])C([H])([H])C([H])([H])C([H])([H])[H])(F)F
Formula:	C26H28F3N3O4
M.Wt:	503.5134
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.

References:

[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8. [2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.