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NAZ2329

  Cat. No.:  DC43996  
Chemical Structure
2809469-05-2
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More than 5000 active chemicals with high quality for research!
Field of application
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 bind
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2809469-05-2
Chemical Name: 3-{[2-Ethoxy-5-(Trifluoromethyl)benzyl]sulfanyl}-N-(Phenylsulfonyl)thiophene-2-Carboxamide
Synonyms: N-(benzenesulfonyl)-3-[[2-ethoxy-5-(trifluoromethyl)phenyl]methylsulfanyl]thiophene-2-carboxamide;3-{[2-Ethoxy-5-(Trifluoromethyl)benzyl]sulfanyl}-N-(Phenylsulfonyl)thiophene-2-Carboxamide;G17717;G17717;MS-29312;MS-29312;7WL;7WL;NAZ2329;NAZ2329;HY-103693;HY-103693;HY-103693;2809469-05-2;2809469-05-2;2809469-05-2;CS-0032821;CS-0032821;CS-0032821
SMILES: S(C1C=CC=CC=1)(NC(C1=C(C=CS1)SCC1C=C(C(F)(F)F)C=CC=1OCC)=O)(=O)=O
Formula: C21H18F3NO4S3
M.Wt: 501.562132358551
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_27664_DC43996
COA
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Cat. No. Product name Field of application
DC73792 NSC74429 NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
DC50265 GDC-1971 GDC-1971 showed outstanding potency in biochemical and cell models, and it had a predicted human PK profile that suggested it would achieve target engagement at reasonable doses. GDC-1971 showed an IC50 below the limit of detection of the assay (≪0.001 μM), while that IC50 shifted to 0.17 μM in the same biochemical assay with the constitutively active E76K SHP2 mutant.
DC47388 PROTAC SHP2 degrader-1 PROTAC SHP2 degrader-1 is a potent and effective SHP2 degrader. PROTAC SHP2 degrader-1 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins and is also neddylation- and proteasome-dependent.
DC47165 CDC25B-IN-2 CDC25B-IN-2 is a potent cdc25B inhibitor.
DC43996 NAZ2329 NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 bind
DC39105 SC-43 SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
DC28481 (E/Z)-BCI(DUSP6 inhibitor) (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
DC11528 Razuprotafib Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor..
DC11638 BCI(NSC 150117) BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish.
DC12013 NSC45586 A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
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