Cat. No. | Product name | CAS No. |
DC7941 |
PF-431396
Featured
PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor , PF-431396 has a Kd value of 445 nM for BRD4. |
717906-29-1 |
DC8526 |
PF4618433
Featured
PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. |
1166393-85-6 |
DC7229 |
PF-4708671
Featured
PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM. |
1255517-76-0 |
DC8395 |
PF-4989216
Featured
PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively. |
1276553-09-3 |
DC8146 |
PF-5006739
Featured
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) |
1293395-67-1 |
DC12373 |
PF-5274857
Featured
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
1373615-35-0 |
DC1107 |
PF-543
Featured
PF-543 is a novel Sphingosine kinase 1 (SphK1, SK1) inhibitor with Ki of 3.6 nM. |
1415562-82-1 |
DC3169 |
PF-562271
Featured
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
717907-75-0 |
DC21504 |
PF-719
Featured
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
1404454-02-9 |
DC7247 |
PF-8380
Featured
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM. |
1144035-53-9 |
DC10783 |
PF-9366
Featured
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. |
72882-78-1 |
DC9305 |
PF-CBP1(PF-06670910) hydrochloride
Featured
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. |
1962928-21-7 |
DC5025 |
PFI-1 (PF-6405761)
Featured
PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM. |
1403764-72-6 |
DC7679 |
(R)PFI-2 HCl
Featured
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. |
1627607-87-7 |
DC7649 |
PFI-3
Featured
PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. |
1819363-80-8 |
DC8291 |
PFI-4
Featured
PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). |
900305-37-5 |
DC8026 |
PFK-015
Featured
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM. |
4382-63-2 |
DC10451 |
PFK158
Featured
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies. |
1462249-75-7 |
DC21665 |
PFM01
Featured
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupt |
1558598-41-6 |
DC12552 |
PGN9856
Featured
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comp |
863704-91-0 |
DC10794 |
PH-002
Featured
PH-002 is a small-molecule structure corrector,inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction,a potent candidate drug for the treament of AD(Alzheimer disease) |
1311174-68-1 |
DC7727 |
PH-797804
Featured
PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM. |
586379-66-0 |