| DC5200 |
HC-030031
Featured
|
HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
|
| DC11416 |
HC-067047
Featured
|
HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). |
|
| DC12620 |
hClpP activator D9
Featured
|
hClpP activator D9 is a potent and species-selective activator of human ClpP (hClpP, human Caseinolytic protease P) by mimicking the natural chaperone ClpX.. |
|
| DC8828 |
HDAC inhibitor IV
Featured
|
HDAC inhibitor IV is a cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. |
|
| DC10596 |
Lavendustin C (HDBA)
Featured
|
HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM. |
|
| DC10613 |
NVP-HDM201(Siremadlin )
Featured
|
HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. |
|
| DC9921 |
Hederacoside C
Featured
|
Hederacoside C is a principal bioactive pharmaceutical ingredient of Hedera helix leaf that can treat respiratory disorders, because of its expectorant, bronchodilator, antibacterial, and bronchospasmolytic effects. |
|
| DC9823 |
Hederagenin
Featured
|
Hederagenin a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases. |
|
| DC21115 |
TD-1
Featured
|
Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. |
|
| DC12294 |
Heparin lithium salt
Featured
|
Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). |
|
| DC1103 |
Hesperadin
Featured
|
Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively. |
|
| DC12195 |
Hexadimethrine bromide
Featured
|
Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction. |
|
| DC10652 |
HG-14-10-04
Featured
|
HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. |
|
| DC21379 |
HG-7-92-01(NG25)
Featured
|
HG-7-92-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases.. |
|
| DC10108 |
HG-9-91-01
Featured
|
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
|
| DC26060 |
gly-arg p-nitroanilide dihydrochloride
Featured
|
H-Gly-Arg-pNA is a colorimetric substrate for thrombin. |
|
| DC8846 |
HhAntag
Featured
|
HhAntag is a GLI1-Mediated transcription inhibitor. |
|
| DC7148 |
LY 379268
Featured
|
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. |
|
| DC20083 |
H-Ile-Pro-Pro-OH
Featured
|
H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides. |
|
| DC10585 |
Hispidol
Featured
|
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
|
| DC10171 |
Hispidulin
Featured
|
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. |
|
| DCAPI1505 |
Darunavir
Featured
|
Darunavir(TMC114) is an HIV protease inhibitor,showed potent activity against COVID-19(SARS-COV-2) . |
|
| DC8163 |
Fostemsavir(BMS-663068)
Featured
|
HIV-1 attachment inhibitor,a prodrug of the small-molecule inhibitor BMS-626529 |
|
| DC21116 |
HJC0197
Featured
|
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP. |
|
| DC7638 |
HJC-0350
Featured
|
HJC-0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells. |
|
| DC9678 |
HLCL-61 hydrochloride
Featured
|
HLCL-61 is a first-in-class small-molecule inhibitor of PRMT5 for treatment of acute myeloid leukemia. |
|
| DC10414 |
HM30181(Encequidar)
Featured
|
HM30181 is a potent and selective inhibitor of P-glycoprotein. |
|
| DC12074 |
HM30181 mesylate
Featured
|
HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor. |
|
| DC8819 |
Olmutinib (HM61713; BI-1482694)
Featured
|
HM-61713 (BI-1482694) is an orally available small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. |
|
| DC10517 |
HMN-154
Featured
|
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively. |
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