Novel HIV replication blocker (EC 50 = 1.66 μM), being actively against a panel of HIV mutant strains displaying resistance to individual drugs used in antiretroviral therapy

Novel potent and selective ferroptosis inducer, inhibiting glutathione peroxidase 4 (GPX4)

Novel high affinity, potent, and selective stabilizer of the MYC G-quadruplex (G4)., inducing cytotoxicity with corresponding decreased MYC mRNA and altering protein binding to the NHE III1 region

Novel dual G-quadruplex/i-motif binder, binding to and stabilizing both G-quadruplex and i-motif, being effective in both oncogene replication and transcription

Potent TrkA kinase inhibitor

Negative control for GI181771X

Selective and brain penetrant NK1-receptor antagonist

Novel inhibitor of the EGFr and C-erbB-2.

5-HT1B/5-HT1D serotonin receptor antagonist

5-HT3 receptor antagonist

Bacterial siderophore with a diazeniumdiolate ligand system

Potent 5HT3 antagonist

Novel Nrf2 modulator via a thus far uncharacterized mechanism

Natural blocker of the voltage-gated sodium channels located in the cell membrane of neurons

Novel orally available, potent and selective inhibitor of Transient Receptor Potential Ankyrin 1 (TRPA1) with IC50 value less than 10 nM

Novel oral specific TRPV1 antagonist, decreasing bladder overactivity and noxious bladder input in cystitis animal models

Natural Potent Inhibitor for Glioblastoma Stem Cell via Targeting RHOA and PI3K/AKT

Novel potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor

Novel, potent, and selective G protein-coupled receptor kinase 6 (GRK6) inhibitor with an IC50 value of 6 nM against GRK6 and selectivity against a panel of 85 kinases

Novel CCR5 inhibitor, inhibiting the replication of wild-type R5-HIV-1

Novel β-Secretase BACE1 Inhibitor, reversing memory impairments and rescuing age-related cognitive decline

Novel allosteric inhibitor of respiratory syncytial virus (RSV)