Home > Inhibitors & Agonists > Others
Cat. No. Product name CAS No.
DC24132 Haloxon

An organophosphorus anthelmintic used against nematodes of the abomasum and small intestine in ruminants. .

321-55-1
DC24008 Eperezolid Featured

An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo..

165800-04-4
DC20418 InS3-54 Featured

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.

328998-92-1
DC22570 eN-IN-1

An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN.

95523-13-0
DC20307 AN-12-H5

AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM.

1193340-31-6
DC12168 AN2718

AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.

174672-06-1
DC23543 ANA975

ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245.

847453-47-8
DC7804 Anacetrapib(MK0859) Featured

Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.

875446-37-0
DC9429 Anagliptin

Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.

739366-20-2
DC9580 Anagrelide (hydrochloride)

Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.

58579-51-4
DCAPI1425 Anastrozole Featured

Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.

120511-73-1
DC20085 Androgen receptor modulators 1

Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM.

1114546-03-0
DC12143 Anemarrhenasaponin I

Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge.

163047-21-0
DC12113 Anemarsaponin E

Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity.

136565-73-6
DC24123 Angiotensin 1-7

Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM.

51833-78-4
DC9348 Angiotensin II human

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

4474-91-3
DC24109 Anguizole

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.

442666-98-0
DCAPI1490 Anidulafungin Featured

Anidulafungin

166663-25-8
DC20670 ANT431 Featured

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

1639972-90-9
DC20671 ANT431 sodium

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

DC23276 Antimalarial compound 49c

Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.

1422207-75-7
DC20308 Antimycin A

Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over.

1397-94-0
DC8959 Antipyrine

Antipyrine is an analgesic and antipyretic agent

60-80-0
DC22094 ANY1

ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA).

482574-02-7
DC20078 AP1867 Featured

AP1867 is a synthetic FKBP12F36V-directed ligand.

195514-23-9
DC22207 AP1903 Featured

AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.

195514-63-7
DC8581 AP219

AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

779282-36-9
DC5198 ALK-IN-1 (Brigatinib analog) Featured

ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

1197958-12-5
DC12705 APA modulator T4

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.

785708-33-0
DC12706 APA modulator T5

APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.

1293394-50-9
DC12636 Apararenone Featured

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis..

945966-46-1
DC8465 Apatinib (free base) Featured

Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities.

811803-05-1
DC20310 Apcin Featured

Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.

300815-04-7
DC8804 APD597(JNJ-38431055) Featured

APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.

897732-93-3
DC22430 APD916

APD916 is a potent and selective antagonist of the H3 receptor with Ki of 0.7 nM for rH3R.

1021169-11-8
DC11077 Azelaprag

apelin receptor.

2049980-18-7
DC21448 Apicidin Featured

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay.

183506-66-3
DC8276 Apilimod mesylate Featured

Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.

870087-36-8
DC23406 Aplaviroc

Aplaviroc (GSK-873140.

461443-59-4
DC23522 Aplaviroc HCl Featured

Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

461023-63-2
DC25100 Apogossypol

Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.

66389-74-0
DC23901 R-(-)-Apomorphine Featured

Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes..

41372-20-7
DC10122 Apoptozole Featured

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity.

1054543-47-3
DC7003 Apricitabine

Apricitabine is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs

160707-69-7
DC10207 Aprotinin

Aprotinin is a serine protease inhibitor isolated from bovine lung which inhibits trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM, respectively.

9087-70-1
DC9809 APS-3-77 HCl Featured

APS-3-77 is the negative binder of KSR2.

DC21999 APTO-253 hydrochloride

APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.

1422731-37-0
DC20672 APX001A Featured

APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris).

936339-60-5
DC11194 APX2009

APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition.

1415030-15-7
DC11195 APX2014

APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.

1415030-17-9
DC23311 AQ-101

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.

1353384-61-8
DC12155 AQ-13 dihydrochloride

AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.

169815-40-1
DC20673 AQW-051

AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56.

669770-29-0
DC23139 AQX 1125

AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator.

782487-28-9
DC20674 AR03

AR03 (AR-03, AR 03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM.

510721-85-4
DC8764 AR 231453 Featured

AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent.

733750-99-7
DC22493 ARA-290(Cibinetide) Featured

ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative.

1208243-50-8
DC8888 Ara-G Featured

Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

38819-10-2
DC10862 Aramchol

Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid.

246529-22-6
DCAPI1051 Arbidol HCl (Umifenovir) Featured

Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc

131707-23-8
DC20675 AR-C102222

AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively.

253771-21-0
DC22544 AR-C155858

AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4.

496791-37-8
DC20265 Arctigenin Featured

Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory,

7770-78-7
DC9659 Arctiin(NSC 315527) Featured

Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.

20362-31-6
DC12359 Arg-AMS

Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.

301351-95-1
DCAPI1329 Argatroban Featured

Argatroban

74863-84-6
DC8841 Argatroban monohydrate Featured

Argatroban monohydrate is a direct, selective thrombin inhibitor.

141396-28-3
DC9645 (+)-Arglabin Featured

Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.

84692-91-1
DC23605 AR-HO47108

AR-HO47108 is a potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 7.0.

248281-68-7
DC10110 ARM390 Hydrochloride Featured

ARM390 is a non-peptidic, low-internalizing δ-selective opioid receptor agonist.

209808-47-9
DC20677 ARN 077

ARN077 is the first potent, selective N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 7 nM on both rat NAAA and human NAAA.

1373625-34-3
DC12569 ARN14494

ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM.

1037837-27-6
DC22000 ARN19874

ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM.

2190502-57-7
DC9345 ARN2966(2-PMAP) Featured

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.

102212-26-0
DC20676 ARN-3261

ARN-3261 is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively.

DC20678 ARN 726

ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA).

1628343-77-0
DC12460 ARP101

ARP101 (ARP-101) is a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells.

849773-63-3
DC7820 ARQ 621 Featured

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

1095253-39-6
DC20679 ARRY-502

ARRY-502 is an orally bioavailable, potent and selective antagonist of the prostaglandin D2 receptor (CRTh2) for treatment of mild to moderate Th2-driven asthma..

1202891-16-4
DC8181 Filanesib(ARRY-520) Featured

ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

885060-09-3
DC9495 ARRY-520 (R enantiomer)

ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

885060-08-2
DC21452 Artefenomel

Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM)..

1029939-86-3
DC21451 Arterolane

Arterolane (OZ277.

664338-39-0
DCAPI1125 Articaine HCl

Articaine is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.

23964-57-0
DC12614 Arylsulfonamide 64B

Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule HIF pathway inhibitor, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.

1342890-83-8
DC20687 AS 2553627

AS 2553627 (AS2553627) is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively.

1251906-07-6
DC22001 AS-1269574 Featured

AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays.

330981-72-1
DC22002 AS1928370

AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM.

1345614-89-2
DC22766 AS-1949490

AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.

1203680-76-5
DC20682 AS2521780

AS2521780 is a potent, selective, orally bioavailable PKCθ inhibitor that inhibits combinant human PKCθ enzyme with IC50 of 0.48 nM, >30-fold higher than other PKC isoforms.

1214726-89-2
DC3112 AS-252424 Featured

AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM.

900515-16-4
DC20683 AS2541019

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms.

2098906-98-8
DC20684 AS2677131

AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM).

2171502-44-4
DC20035 AS2717638 Featured

AS2717638 is an oral active lysophosphatidic acid receptor 5 (LPA5) antagonist in rodents. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.

2148339-28-8
DC11460 AS604850 Featured

AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.

648449-76-7
DC11407 Asapiprant(BGE-175) Featured

Asapiprant (BGE-175) is a potent and specific antagonist of human PGD2/PTGDR signaling with Ki of 0.44 nM. BGE-175 is currently in a Phase 2 clinical trial to test whether it can prevent disease progression and mortality in older patients hospitalized wit

932372-01-5
DC20622 Asciminib Featured

Asciminib (ABL-001) is a potent and selective allosteric ABL1 inhibitor with IC50 of 0.25 nM in BCR–ABL1-transformed BaF3 cells.

1492952-76-7
DC1049 Ascomycin (Immunomycin,FK-520) Featured

Ascomycin is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities.

104987-12-4
DCAPI1060 L-Ascorbyl 6-palmitate Featured

Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.

137-66-6
DC10704 Asimadoline (EMD-61753) Featured

Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist.

153205-46-0
DC21100 Gusacitinib (ASN-002) Featured

ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays.

1425381-60-7
DC20109 ASP-4058

ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.

952565-91-2
DC20218 ASP5878 Featured

ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.

1453208-66-6
DC23457 ASP6432

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.

1282549-08-9
DC20693 ASP9436

ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes.

1401807-89-3
DC10588 ASP-9521 Featured

ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.

1126084-37-4
DC22003 Aspacytarabine

Aspacytarabine (Astarabine, BST236) is a cytarabine conjugate that shows anti-​neoplastic agents for inhibiting cancer cell growth. .

2098942-53-9
DC12360 Asp-AMS

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

828288-98-8
DCAPI1120 Aspartame

Aspartame

22839-47-0
DC20148 Astaxanthin

Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is an inhibitor of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin has potential in the treatment of various di

472-61-7
DC23804 Astex ERK inhibitor X

Astex ERK inhibitor X is a novel potent ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM in TRK kinase assays.

2095719-90-5
DC12617 Astin C

Astin C is a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs, inhibits intracellular DNA-induced Ifnb expression with IC50 of 3.42 and 10.83 uM

148057-23-2
DC8641 Astragaloside A Featured

Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems.

83207-58-3
DC12126 Astragaloside VI

Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing.

84687-45-6
DC20696 ASTX660 hydrochloride

ASTX660 hydrochloride is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.

1799328-50-9
DC20695 ASTX660(Tolinapant) Featured

ASTX660 is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.

1799328-86-1
DC20697 ASTX660 mesylate

ASTX660 mesylate is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.

1799328-90-7
DC7361 Asunaprevir Featured

Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor.

630420-16-5
DC22401 AT-090

AT-090 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 5.61 nM.

2099681-59-9
DC20080 AT-1002 Featured

AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.

835872-35-0
DC26065 AT-127 Featured

AT-127 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM.

2099680-72-3
DC20699 AT-130 Featured

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.

211364-06-6
DC7362 AT13148 Featured

AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity; AKT, p70S6K, PKA, ROCK, and SGK inhibitor.

1056901-62-2
DC20698 AT-403

AT-403 (AT403) is a potent, highly selective, nonpeptide NOP agonist with pEC50 of 9.45.

DC7363 AT-406 Featured

AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

1071992-57-8
DC23554 AT791

AT791 is a novel orally available, small molecule inhibitor of TLR7 and TLR9 with IC50 of 3.33 uM and 0.04 uM respectively, inhibits DNA-TLR9 interaction in vitro.

1219962-49-8
DC21122 Ataciguat sodium

Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.

254976-06-2
DC21121 Ataciguat Featured

Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.

254877-67-3
DC23606 Atagabalin

Atagabalin (PD 0200390) is a novel ligand of the voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) for treatment for insomnia..

223445-75-8
DC7365 ATB-346 Featured

ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.

1226895-20-0
DC7366 Atglistatin Featured

Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM.

1469924-27-3
DC21656 Atiprimod

Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.

123018-47-3
DC21657 Atiprimod dihydrochloride

Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.

130065-61-1
DC20033 ATM Inhibitor-1

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0

2135639-94-8
DC12627 ATM-3507

ATM-3507 (ATM3507) is a small molecule inhibitor of Tpm3.1 tropomyosin isoform, disrupts Tpm3.1-containing microfilaments in SK-N-SH cells at 5 uM.

1861449-70-8
DC7709 ATN-161 Featured

ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

262438-43-7
DCAPI1522 Atocalcitol

Atocalcitol

302904-82-1
DC23607 Atomoxetine

Atomoxetine ((R)-Tomoxetine.

83015-26-3
DCAPI1390 Atovaquone (Atavaquone) Featured

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

95233-18-4
DCAPI1401 ATP (Adenosine-Triphosphate)

ATP (Adenosine-Triphosphate)

987-65-5
DC11095 ATR-101 free base

ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.

133825-80-6
DC22775 ATR-101

ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.

133825-81-7
DC23072 Atractylenolide II Featured

Atractylenolide II has antiinflammatory activity, it can inhibit platelets activities and thrombus formation. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK and Akt inactivation, p53 dependent, it also has antimelanoma effe

73069-14-4
DC23073 Atractylenolide III Featured

Atractylenolide III, a potential house dust mite control agent, has neuroprotection, gastroprotective, anti-cancer, and anti-inflammatory activities, it also may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

73030-71-4
DC23059 Atractylon Featured

Atractylone has inhibitory effects on mast cell-mediated allergic reactions, it regulates the degranulation of mast cell, proves its potential in the treatment of mast cell-mediated allergic reactions.

6989-21-5
DCAPI1288 Atracurium besylate Featured

Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.

64228-81-5
DC22004 ATV399

ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS.

393834-37-2
DC20114 ATWLPPR Peptide TFA

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes.

DC23401 AU1

AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4.

1802251-00-8
DC21865 Aumitin Featured

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I.

946293-78-3
DC12428 AUNP-12 Featured

AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways.

1353563-85-5
DC26036 Aurantiamide acetate

Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux.

56121-42-7
DC20312 Aurintricarboxylic acid

Aurintricarboxylic acid (ATA) is a potent small molecule inhibitor of RISC loading with IC50 of 0.47 uM, inhibits RISC activity against transiently expressed reporters and endogenous genes.

4431-00-9
DC10138 Auristatin E Featured

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

160800-57-7
DC20037 Aurora inhibitor 1

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively.

2227019-45-4
DC26118 AKI-7169(Aurora Kinase Inhibitor III) Featured

Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).

879127-16-9
DC21866 Autotaxin inhibitor 12

Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.

1613513-14-6
DC20701 Autotaxin inhibitor compound 1

Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay, does not inhibit related proteins ENPP1 and ENPP7.

1619971-30-0
DC22219 Auxin agonist RN3

Auxin agonist RN3 (RubNeddin 3) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development.

425609-03-6
DC22220 Auxin agonist RN4

Auxin agonist RN4 (RubNeddin 4) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development.

433950-87-9
DC22012 Avanbulin

Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays.

798577-91-0
DC1094 Avasimibe Featured

Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.

166518-60-1
DC20703 AVE-0118

AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency.

498577-53-0
DC10732 Anavex-2-73 free base (Blarcamesine) Featured

AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease

195615-83-9
DC12715 AVG-233

AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM).

2151937-80-1
DC8351 Avibactam sodium Featured

Avibactam sodium(NXL-104) is a non-β-lactam β-lactamase inhibitor antibiotic.

1192491-61-4
DC24068 AVL-292 besylate Featured

AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM.

1360053-81-1
DC8565 AVN944 Featured

AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.

297730-17-7
DCAPI1313 Avobenzone(Parsol 1789)

Avobenzone(Parsol 1789)

70356-09-1
DC26015 Deudextromethorphan Featured

AVP-786 is a novel, next-generation investigational drug product consisting of a combination of deudextromethorphan, and an ultra-low dose of quinidine.

1079043-55-2
DC20709 AW-814141

AW-814141 is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.

905285-51-0
DC7071 AWD 131-138(Imepitoin) Featured

AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

188116-07-6
DC20243 AWZ1066S Featured

AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

2239272-16-1
DC10412 AX20017 Featured

AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.

329221-38-7
DC20313 Axl-IN-21

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM.

2086274-31-7
DC23895 AY-9944 Featured

AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.

366-93-8
DC11371 AY-NH2 Featured

AY-NH2 is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively).

352017-71-1
DC23879 AZ 4800

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38..

1226886-78-7
DC20710 AZ0108

AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively.

1825345-52-5
DC20314 AZ-1

AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.

803735-54-8
DC20711 AZ10606120 dihydrochloride Featured

AZ10606120 is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively.

607378-18-7
DC12613 AZ12204657

AZ12204657 (AZ-12204657) small-molecule GPR44 antagonist, displaces the binding of [3H]PGD2 from membranes of HEK293 cells transfected with human recombinant GPR44 with IC50 of 2.5 nM.

847148-49-6
DC22724 AZ12441970

AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8.

929551-91-7
DC12530 AZ12601011

AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM.

DC12531 AZ12799734

AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGF

1117684-36-2
DC21406 AZ-1355

AZ-1355 is an effctive lipid-lowering compound that inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro..

75451-07-9
DC20712 AZ13705339 Featured

AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4.

2016806-57-6
DC20713 AZ13711265

AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4.

2016806-55-4
DC23484 AZ1729

AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways.

2016864-46-1
DC20315 AZ-2

AZ-2 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.

788146-30-5
DC7906 AZ20 Featured

AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.

1233339-22-4
DC23855 AZ-23

AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively.

915720-21-7
DC9667 AZ-33(AZ33) Featured

AZ-33 is a inhibitor of LDH-A with an IC50 of 0.5 μM.

1370290-34-8
DC20715 AZ-4217

AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.

1383846-83-0
DC22293 AZ-505 ditrifluoroacetate Featured

AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM.

1035227-44-1
DC8842 AZ-7371(DprE1-IN-1) Featured

AZ-7371(DprE1-IN-1) is a novel non-covalent DprE1 inhibitor.

1494675-86-3
DC12677 AZ876 Featured

AZ876 is a novel high-affinity LXR agonist.

898800-26-5
DC23407 AZ8838 racemate

AZ8838 racemate(AZ-8838 racemate) is the racemate form of AZ8838, which is a potent, and selective PAR2 antagonist with Kd of 125 nM..

2100283-63-2
DCAPI1182 Azathioprine (Azasan, Imuran) Featured

Azathioprine (Azasan, Imuran) is the analytical standard of Azathioprine. This product is intended for research and analytical applications. Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.

446-86-6
DC23851 AZD 0424

AZD 0424 is an orally bioavailable small molecule tyrosine kinase inhibitor of Abl and Src kinase with potential antineoplastic activity..

692054-06-1
<Prev1...1314151617...127Next>