| DC72812 |
Flurandrenolone Acetate |
Flurandrenolone Acetate is a derivative of Flurandrenolide. Flurandrenolone Acetate is a synthetic glucocorticoid steroid, can be used for the research of skin disorders such as eczema and psoriasis. |
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| DC72814 |
5'-Hydroxy-staurosporine |
5'-Hydroxy-staurosporine is an indolocarbazole alkaloid that can be isolated from marine Micromonospora sp. (strain L-31-CLCO-002). 5'-Hydroxy-staurosporine can be used in tumor related research. |
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| DC72815 |
(S)-ar-Curcumene |
(S)-ar-Curcumene ((+)-alpha-Curcumene) is a natural compound. (S)-ar-Curcumene is a constituent of the essential oil that can isolated from the rhizomes of Curcuma aromatica and is an odour component of distantly related corals. |
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| DC72822 |
MS023 hydrochloride
Featured
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MS023 hydrochloride is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. |
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| DC72823 |
SU056
Featured
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SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells. |
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| DC72824 |
TH1760 |
TH1760 is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM. |
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| DC72825 |
Lapyrium chloride |
Lapyrium chloride(NSC-33659) is used as a cosmetic ingredient, cationic emulsifier, detergent-germicide, deodorant and anti-static agent. |
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| DC72828 |
LY3000328 |
LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for human Cat S and mouse Cat S, respectively. |
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| DC72830 |
N-hydroxymethyl succinimide |
N-hydroxymethyl succinimide is used as pharmaceutical intermediate. |
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| DC72832 |
(R)-V-0219 |
(R)-V-0219 is an enantiomer of V-0219. V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R. |
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| DC72834 |
PF-07059013 |
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research. |
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| DC72836 |
Thiotraniliprole |
Thiotraniliprole (HY366) is an ortho formamidobenzamide insecticide that can be used for the synthesis of insecticidal combinations. Thiotraniliprole has potential applications in the prevention of lepidoptera pests, coleoptera pests, ants, and termites. |
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| DC72839 |
Culmerciclib maleate |
Culmerciclib maleate is a cyclin dependent kinase (CDK) inhibitor, and has antineoplastic activity. |
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| DC72844 |
Fmoc-DON-Boc |
Fmoc-DON-Boc (Compound 8b) is an Fmoc-protected compound that can be used for the synthesis of proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357). DON is a glutamine antagonist. |
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| DC72855 |
BT7480 |
BT7480 (BCY11863) is one of the Bicycle tumor-targeted immune cell agonists (Bicycle TICAs). BT7480 is an angonist of CD137 (4-1BB). BT7480 consists of a poly(ethylene glycol) (PEG)-based linker, and a synthetic Bicycle peptide targeting CD137 conjugated to Bicycles targeting Nectin-4. Nectin-4 is a cell adhesion molecule, overexpressing in multiple tumor cells. BT7480 elicits significant CD137 agonism and potent antitumor activity in syngeneic mouse models. |
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| DC72857 |
Glutaraldehyde |
Glutaraldehyde(Glutaric dialdehyde, Pentane-1,5-dial) is an effective biochemical reagent used as a protein crosslinker, enzyme immobilization microscopy, histochemistry, and cytochemistry. |
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| DC72858 |
3,4-Dichlorophenyl isothiocyanate |
3,4-Dichlorophenyl isocyanate(1,2-Dichloro-4-isothiocyanatobenzene) is a chemical compound used as a chemical intermediate and in organic synthesis. |
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| DC72859 |
1-Thioglycerol |
1-Thioglycerol(Mercaptopropanedioltech) is an inhibitor of glycerol kinase activity. It stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. |
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| DC72862 |
Formamide
Featured
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Formamide (Methanamide; Formimidic acid) is a clear liquid amide derived from formic acid. It allows for the denaturation and renaturation of nucleic acids at room temperature. Formamide-induced DNA denaturation when combined with detection of denatured DNA with a monoclonal antibody (MAb) makes it possible to specifically identify the apoptotic cells. |
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| DC72865 |
Hi 76-0079 |
Hi 76-0079 (NNC0076-0079) is a specfic, small molecule inhibitor of hormone-sensitive lipase (HSL) with IC50 of 0.11 uM.
Hi 76-0079 does not affect ATGL or other lipases (IC50>50 uM).
Hi 76-0079 inhibits lipolysis in vivo. |
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| DC72871 |
FHP01
Featured
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FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively).
FHP01 does not inhibit the ATPase activity of DDX3X and the helicase activity of DDX1 (IC50>100 uM).
FHP01 also inhibited WNT signaling, a key tumorigenic pathway already correlated to DDX3X functions in breast cancer model cell lines.
FHP01 inhibits ER+/PR+ (IC50 = 12.43 and 10.62 μM in MCF7 and T47D cells, respectively) and HER2+ (IC50 = 13.46 μM in SKBR3) cells, but lower in control MCF10A cells (IC50 = 28.71 μM).
FHP01 (45 mg/kg, i.p. injection) suppresses rowth of MDA MB 231 tumor xenografts in nude mice. |
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| DC72874 |
IMU-838 |
Vidofludimus (IMU-838) is a selective and potent second-generation dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 160 nM, shows anti-SARS-CoV-2 activity with EC50 of 7.6 uM in Vero cells.
Vidofludimus inhibits T cell proliferation with EC50 of 11.8 uM, with a similar effect on CpG ODN 2006-PTO dependent B cell proliferation.
Vidofludimus is specific for human DHODH and does not have off-target effect on kinases, is about 7.5-fold and about 64.4-fold more active on human DHODH as compared to rat DHODH and mouse DHODH, respectively.
Vidofludimus inhibits specifically IL–17F, IL–17A and IFN-g expression in PBMCs.
Vidofludimus is 2.6 times more potent in inhibiting DHO oxidation by human DHODH compared to teriflunomide (IC50=420 nM).
Vidofludimus shows inhibition of rat EAE motor signs in a rat experimental autoimmune encephalomyelitis (EAE) model.
Vidofludimus exerts a broad-spectrum activity against a selection of major human pathogenic viruses. |
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| DC72876 |
BDM44768 |
BDM44768 (BDM 44768) is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE).
BDM44768 displays excellent selectivity over a panel of metalloproteases (>45-fold selectivity over hNEP and hECE, no significant acitivity against hACE and hMMP-1).
BDM44768 significantly increased concentrations of Aβ1-40 in culture supernatants of human SY5Y neuroblastoma cells.
Acute treatment of mice with BDM44768 (50 mg/kg, i.p.) increases insulin signalling and surprisingly impairs glucose tolerance in an IDE-dependent manner in C57BL/6J mice. |
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| DC72883 |
GBT1118 |
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia. |
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| DC72884 |
Ethyl methanesulfonate |
Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. It induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. |
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| DC72893 |
TP-1454
Featured
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TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells. |
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| DC72895 |
CYCA-117-70 |
CYCA-117-70 is a DCAF1 ligand (KD: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1. |
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| DC72906 |
BCPA
Featured
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BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research. |
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| DC72909 |
JH530 |
JH530 is an effective methuosis inducer that inhibits the triple-negative breast cancer (TNBC) cells proliferation by causing intracellular complete vacuolization. JH530 has anti-tumor activity and can be used for cancer research. |
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| DC72913 |
AP 811 acetate |
AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation. |
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