| DC9872 |
NSC15364
Featured
|
NSC15364 is an inhibitor of Shiga Toxin. |
|
| DC12657 |
NSC228155
Featured
|
NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation. |
|
| DC9989 |
NSC23005 free acid
Featured
|
NSC23005 is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
|
| DC9988 |
NSC23005 sodium
Featured
|
NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
|
| DC11269 |
MSX-127（NSC23026）
Featured
|
NSC-23026, also known as MSX-127, is a CXCR4 receptor modulator. |
|
| DC12478 |
NSC 260594
Featured
|
NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ). |
|
| DC8715 |
NSC305787 |
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. |
|
| DC8746 |
NSC319726
Featured
|
NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells. |
|
| DC9641 |
NSC348884
Featured
|
NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. |
|
| DC12459 |
NSC49652 |
NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian c |
|
| DC9672 |
NSC5844 (RE640)
Featured
|
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
|
| DC9257 |
NSC59984
Featured
|
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells. |
|
| DC20228 |
NSC617145(WRN inhibitor)
Featured
|
NSC617145 is a Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM). |
|
| DC10001 |
NSC632839
Featured
|
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively. |
|
| DC22183 |
NSC668394 |
NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM. |
|
| DC5145 |
NSC697923
Featured
|
NSC697923 is a selective inhibitor of Ubc13-Uev1A |
|
| DC10484 |
NSC781406
Featured
|
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα. |
|
| DC10212 |
NSC-87877 |
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
|
| DC7165 |
NSI-189
Featured
|
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine. |
|
| DC9754 |
NT-157
Featured
|
NT157 is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) . |
|
| DC11260 |
NTCP binder peptide WD1 |
NTCP binder peptide WD1 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=15 nM), reduces HBs antigen levels in culture supernatants. |
|
| DC11259 |
NTCP binder peptide WL4 |
NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM. |
|
| DC21429 |
NTRC-844 |
NTRC-844 (NTRC844) is a potent, selective neurotensin receptor type 2 (NTS2) with Ki of 23 nM, 100-fold selectivity over NTS1 receptor. |
|
| DC7935 |
NU1025
Featured
|
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). |
|
| DC8214 |
NU6027
Featured
|
NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 µM, respectively. |
|
| DC10734 |
NU2058
Featured
|
NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1. |
|
| DC8716 |
NU6300 |
NU6300 is a non-covalent ATP-competitive CDK2 inhibitor (IC50 = 0.16 mM). |
|
| DC5047 |
NU7026
Featured
|
NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. |
|
| DC3100 |
NU-7441 (KU-57788)
Featured
|
NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM. |
|
| DC26038 |
NUC-1031(SP) |
NUC-1031(SP) is S form of NUC-1031 at P site.Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
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