DC26034 |
NUC3373(Fosifloxuridine nafalbenamide)
Featured
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NUC-3373 is a phosphoramidate-based prodrug of the monophosphate form of 5-fluoro-2'-deoxyuridine, the active metabolite of fluorouracil,an antimetabolite fluoropyrimidine analog of the pyrimidine nucleoside, with potential antineoplastic activity. |
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DC26035 |
NUC-7738
Featured
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NUC-7738 is a phosphoramidate transformation of cordycepin (3’-deoxyadenosine; 3’-dA), a derivative of adenosine that was first isolated from Cordyceps sinensis. |
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DC9416 |
Nuclear yellow |
Nuclear yellow (Hoechst S769121) exhibits excitation/emission maxima ~335/495 nm when bound to DNA.
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DC9486 |
Nucleozin
Featured
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Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. |
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DC3125 |
Nutlin-3
Featured
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Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM. |
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DC8454 |
Nutlin-3a
Featured
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Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. |
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DC8455 |
Nutlin-3b |
Nutlin-3b is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (−)-nutlin-3, demonstrating an IC50 value of 13.6 µM. |
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DC21931 |
NV01 |
NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM.. |
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DC21932 |
NV03 |
NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM.. |
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DC7988 |
NVP-DPP728 dihydrochloride |
NVP DPP 728 is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively. |
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DC21430 |
NVP-2
Featured
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NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 µM, 0.7 |
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DC8312 |
NVP-231 |
NVP-231 is a potent, specific, and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits binding of ceramide to CerK. |
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DC7576 |
NVP-AAM077
Featured
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NVP-AAM077 is a potent antagonist for NMDA receptors. |
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DC8794 |
NVP-ACC-789
Featured
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NVP-ACC789 is an inhibitor of VEGFR-2 (FLK-1/KDR). |
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DC7549 |
NVP-ADW742
Featured
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NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
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DC4174 |
NVP-AEW541
Featured
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NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM. |
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DC7250 |
NVP-BAG956(BAG 956) |
NVP-BAG956(BAG 956) is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo,with IC50 values to be 56, 444, 34, 117 and 240 nM for PI3K p110 alpha, beta, delta and gamma and PDK1 kinases, respectively. |
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DC9680 |
NVP-BAW2881
Featured
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NVP-BAW2881 is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor |
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DC4118 |
NVP-BEP800
Featured
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NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
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DC24053 |
NVP-BGJ398 phosphate
Featured
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NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM. |
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DC3133 |
NVP-BGT226 (BGT226)
Featured
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NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
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DC7473 |
NVP-BHG712
Featured
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NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. |
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DC10540 |
NVP-BQR695
Featured
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NVP-BQR695 is a novel PI3K inhibitor. |
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DC7216 |
NVP-BSK805 dihydrochloride
Featured
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NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2. |
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DC8743 |
NVP-BVU972
Featured
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NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). Antitumor agents. |
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DC9769 |
NVP-CGM097 (CGM-097)
Featured
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NVP-CGM097 (CGM-097) is a potent and selective MDM2 inhibitor. |
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DC9392 |
NVP-LCQ195
Featured
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NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
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DC22564 |
NVP-MELK8a hydrochloride
Featured
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NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM. |
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DC7474 |
NVP-QAV-572 |
NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM. |
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DC7701 |
NVP-QAV680 |
NVP-QAV680 is a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. |
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