RO7185876

  Cat. No.:  DC48365   Featured
Chemical Structure
2226038-71-5
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More than 5000 active chemicals with high quality for research!
Field of application
RO7185876 is a potent and selective gamma secretase modulator as a potential treatment for Alzheimer's disease.
Cas No.: 2226038-71-5
Chemical Name: RO7185876
Synonyms: RO7185876
SMILES: N(C1([H])[C@@H]2CC[C@H]1CN(C1=NC=NC(C)=C1)C2)C1=NN2CCCC[C@@H](C3C=CC(F)=C(F)C=3F)C2=N1
Formula: C25H28F3N7
M.Wt: 483.53
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_32256_DC48365_2226038-71-5
COA
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Cat. No. Product name Field of application
DC48365 RO7185876 RO7185876 is a potent and selective gamma secretase modulator as a potential treatment for Alzheimer's disease.
DC47320 FRM-024 FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.
DC7666 MK0752 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
DC8215 RO4929097 RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.
DC10926 LY900009 LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
DC5036 LY-411575 LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM.
DC8615 L-685,458 L-685,458 is a selective and Potent inhibitor of γ-secretase with IC50 value of 17 nM.
DC8277 E-2012 E 2012 is a potent γ-secretase modulator.
DC7396 DAPT DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma.
DC3114 Avagacestat (BMS-708163) BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.
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