| DC48365 |
RO7185876
|
RO7185876 is a potent and selective gamma secretase modulator as a potential treatment for Alzheimer's disease. |
| DC47320 |
FRM-024
|
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease. |
| DC7666 |
MK0752
|
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2. |
| DC8215 |
RO4929097
|
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. |
| DC10926 |
LY900009
|
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. |
| DC5036 |
LY-411575
|
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
| DC8615 |
L-685,458
|
L-685,458 is a selective and Potent inhibitor of γ-secretase with IC50 value of 17 nM. |
| DC8277 |
E-2012
|
E 2012 is a potent γ-secretase modulator. |
| DC7396 |
DAPT
|
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma. |
| DC3114 |
Avagacestat (BMS-708163)
|
BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
