Corr4A

  Cat. No.:  DC12003   Featured
Chemical Structure
421580-53-2
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More than 5000 active chemicals with high quality for research!
Field of application
A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..
Cas No.: 421580-53-2
Chemical Name: N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide
Synonyms: ST075396; MLS000561131; Corr-4a; Oprea1_189688; Oprea1_471654; CHEMBL260775; MolPort-001-986-142; ZINC00888741; AKOS001665304;
SMILES: COC1=C(C=C(Cl)C=C1)NC2=NC(=CS2)C3=C(C)N=C(NC(=O)C4=CC=CC=C4)S3
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC70796 SRI-41315 SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
DC12003 Corr4A A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..
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