SRI-41315|CAS 1613509-49-1|DC Chemicals

Cas No.:	1613509-49-1
Chemical Name:	Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
Synonyms:	Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
SMILES:	N1(C)C2=C(C=CC=C2)C(=O)C2C(=O)N(C3=CC=CC=C3)C(C3CCC3)=NC1=2
Formula:	C₂₂H₁₉N₃O₂
M.Wt:	357.405164957047
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC70796	SRI-41315	SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
DC12003	Corr4A	A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..