Alternate Text DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
Home > Products > Novel inhibitors

GZD824 dimesylate

  Cat. No.:  DC41084   Featured
Chemical Structure
1421783-64-3
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
Get Quotation Now
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
GZD824 dimesylate (HQP1351 dimesylate) is an orally bioavailable pan-Bcr-Abl inhibitor with potency against a wide range of Bcr-Abl mutants and the native enzyme (IC50=0.34 nM). GZD824 dimesylate has antitumor activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1421783-64-3
Chemical Name: Olverembatinib dimesylate
Synonyms: GZD824;Benzamide, 4-​methyl-​N-​[4-​[(4-​methyl-​1-​piperazinyl)​methyl]​-​3-​(trifluoromethyl)​phenyl]​-​3-​[2-​(1H-​pyrazolo[3,​4-​b]​pyridin-​5-​yl)​ethynyl]​-​, methanesulfonate;GZD824DIMESYLATE;GZD824 dimesylate;Olverembatinib dimesylate
SMILES: CC1C=CC(C(NC2C=CC(CN3CCN(C)CC3)=C(C(F)(F)F)C=2)=O)=CC=1C#CC1C=NC2NN=CC=2C=1.CS(O)(=O)=O.CS(O)(=O)=O
Formula: C31H35F3N6O7S2
M.Wt: 724.770815134048
Sotrage: 4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
MSDS
TITLE DOWNLOAD
MSDS_24097_DC41084_1421783-64-3
COA
LOT NO. DOWNLOAD
Cat. No. Product name Field of application
DC72877 PF-114 Vamotinib (PF-114) is a potent, selective and orally available inhibitor of native (IC50=0.49 nM) and mutated BCR/ABL (IC50=0.7-4 nM, ABL (T315I) IC50=0.78 nM). PF-114 potently inhibits ABL2, DDR1, DDR2, FMS, FRK, LCK, LYN and PDGFR kinases, but did not inhibit c-SRC, CSK, or c-KIT.
DC44827 Vodobatinib Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research.
DC41084 GZD824 dimesylate GZD824 dimesylate (HQP1351 dimesylate) is an orally bioavailable pan-Bcr-Abl inhibitor with potency against a wide range of Bcr-Abl mutants and the native enzyme (IC50=0.34 nM). GZD824 dimesylate has antitumor activity.
DC4181 Imatinib mesylate Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
DC9285 GNF-7 GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.
DC10060 Dianilinopyrimidine_01(CZC8004) Dianilinopyrimidine_01 is a Pan Tyrosine kinase inhibitor.
DC5041 DCC-2036 (Rebastinib) DCC-2036 is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1/2.
DC1020 Ponatinib (AP24534) AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
X
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Site Map|Privacy PolicyCopyright © 2018-2020 All Rights Reserved. Technical Support:KuuJia