| DC21411 |
Thioflavin S |
A homogenous mixture of compound that is used to stain amyloid plaques, binds to amyloid fibrils but not monomers and gives a distinct increase in fluorescence emission.. |
|
| DC22453 |
Sappanone A
Featured
|
A homoisoflavanone found in Caesalpinia sappan, a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with Kd of 3.944 nM, almost 10 times lower than the Kd of binding to IMPDH1. |
|
| DC11590 |
Homo-PROTAC pVHL30 degrader 1
Featured
|
CM-11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation. |
|
| DC24087 |
Calcipotriol monohydrate
Featured
|
A hormonally active metabolite of vitamin D that binds to vitamin D receptor (VDR). |
|
| DC23962 |
Cilobradine
Featured
|
A hyperpolarization-activated cyclic nucleotide-gated (HCN) channel. |
|
| DC11933 |
RX 871024 |
A imidazoline compound that stimulate insulin release by inhibition of ATP-dependent K+ channels and inducing of Ca2+ mobilization in mouse pancreatic beta-cells. |
|
| DC23269 |
Carrageenan |
A linear sulfated polysaccharide extracted from red edible seaweeds, shows topical microbicide activity targeting HIV viruses. |
|
| DC24160 |
Benzydamine hydrochloride |
A locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions. |
|
| DC22626 |
Bambuterol |
A long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma. |
|
| DC20991 |
Etacrynic acid |
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue. |
|
| DC11646 |
ML67-33
Featured
|
A low micromolar (EC50=9.7 uM, K2P2.1), selective activator of temperature- and mechano-sensitive K2P potassium channels. |
|
| DC22825 |
Azathramycin |
A macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer. |
|
| DC21367 |
NC1153 |
A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b. |
|
| DC11718 |
Debromohymenialdisine |
A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively. |
|
| DC25020 |
Seriniquinone |
A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. |
|
| DC24056 |
Agomelatine hydrochloride
Featured
|
A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
|
| DC24055 |
Agomelatine L(+)-Tartaric acid
Featured
|
A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
|
| DC11502 |
2-APB |
A membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blcoker. |
|
| DC26095 |
QX 314 chloride
Featured
|
A membrane-impermeable sodium channel blocker, blocks sodium current in voltage-clamped nociceptive DRG neurons. |
|
| DC22354 |
O-Desmorpholinopropyl Gefitinib |
A metabolite of Gefitinib, which is a potent inhibitor of tyrosine phosporylation in EGFR.. |
|
| DC22914 |
ST-4206 |
A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.. |
|
| DC22824 |
Endoxifen hydrochloride |
A metabolite of tamoxifen, orally active non-steroidal selective estrogen receptor modulator (SERM) for the treatment of estrogen receptor-positive breast cancer.. |
|
| DC23973 |
F16
Featured
|
A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. |
|
| DC7289 |
Imiloxan |
A moderately potent, but highly selective α2-adrenoceptor antagonist, the only reported selective antagonist at the α2B-adrenoceptor not having potent α1-adrenoceptor antagonist activity. |
|
| DC23225 |
Dronedarone |
A multichannel blocker agent that has antiarrhythmic activity. |
|
| DC21008 |
Fumonisin B1 |
A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS). |
|
| DC23641 |
AMG 747 |
A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia. |
|
| DC11530 |
Tapinarof (Benvitimod; GSK2894512)
Featured
|
Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice. |
|
| DC11658 |
Diptoindonesin G
Featured
|
Dip G is a natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
|
| DC24167 |
Bergaptol |
A natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
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