| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC21706 | STX3451 | A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM. |
|
| DC11919 | Arimoclomol Featured | A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC11920 | Arimoclomol maleate Featured | A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC24034 | Coluracetam | A nootropic agent that enhances high-affinity choline uptake. |
|
| DC21342 | MPT0L145 | A nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3. |
|
| DC20550 | SHP2 inhibitor 2 | A nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM. |
|
| DC11523 | Landipirdine | A novel 5-HT receptor antagonist for the treatment of Parkinson's disease.. |
|
| DC11793 | UMB-32 | A novel a potent, selective inhibitor of BRD4 with Kd of 550 nM, cellular IC50 of 724 nM. |
|
| DC23493 | Ladarixin | A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM. |
|
| DC23467 | Ladarixin sodium | A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM. |
|
| DC20706 | AVN-211 | A novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM. |
|
| DC22565 | K-Ras G12C-IN-3 | A novel and irreversible inhibitor of mutant K-ras G12C.. |
|
| DC22572 | K-Ras G12C-IN-2 | A novel and irreversible inhibitor of mutant K-ras G12C.. |
|
| DC22573 | K-Ras G12C-IN-1 | A novel and irreversible inhibitor of mutant K-ras G12C.. |
|
| DC22587 | FT011 Featured | FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis. |
|
| DC11888 | Arfolitixorin | A novel antifolate modulator compound.. |
|
| DC22391 | Olorofim(F-901318) | Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. |
|
| DC11998 | IND-114338 | A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc.. |
|
| DC11534 | Sudoterb Featured | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11535 | Sudoterb dihydrchloride | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11663 | GS-5759 | A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM). |
|
| DC11997 | IND125 | A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum. |
|
| DC11792 | UMB-136 | A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation. |
|
| DC22507 | SCH-00013 | A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM). |
|
| DC11785 | IHR-1 | A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC11784 | IHR-Nac | A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC22789 | 5S rRNA modificator 2 | A novel chemical probe that enable selective 2’-hydroxyl acylation for accurate RNA structural analysis in living cells.. |
|
| DC11628 | HIV-1 Integrase Inhibitor 1 | A novel compound that disrupts the HIV-1 integrase LEDGF interaction. |
|
| DC11521 | Dotinurad Featured | Dotinurad is a novel compound that exhibits a remarkable uric acid excretion-promoting action. |
|
| DC20796 | BIOD303 | A novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
|
