Novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance

Novel Hsp90 inhibitor

Potent Androgen_receptor>androgen receptor (AR) pure antagonist which did not produce the agonist metabolite

Novel Hsp90 inhibitor

Novel inhibitor of mitochondrial respiration, targeting drug-resistant cancer cells with stem-like features by inhibiting mitochondrial respiration complex I (NADH:ubiquinone oxidoreductase, complex I [CI])

The desmethyl precursor of CHDI-180R which is a first-in-class high-affinity PET imaging ligand specific for mHTT aggregates

Novel potent and selective kynurenine mono-oxygenase (KMO) inhibitor

Novel intracellular chelator, disrupting iron homeostasis in bacteria

Novel inhibitor against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum

Inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase

Novel potent and orally active ChemR23 inhibitor (IC 80 = 12 nM), showing a long-acting effect in cynomolgus monkeys

Novel dual inhibitor of cholinergic dysfunction and amyloid deposition for AD treatment, penetrating the blood-brain barrier (BBB) and enhancing the cerebral acetylcholine level

Novel acetylcholinesterase inhibitor

Potent, tissue-selective estrogen receptor modulator

Potent, long-acting, and selective muscarinic M3 receptor antagonist

Novel Potent and Selective Chikungunya Virus Envelope Protein Inhibitor

Novel potent inhibitor of HIV-1 integrase

Antiviral and antifungal agent

Widely used biocidal agent

Sympathomimetic agent, facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibiting their uptake

Serotonin transporter substrate

Hydrophilic prodrug of CHM-1