Cat. No. | Product name | CAS No. |
DC7385 |
CID-755673
Featured
CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. |
521937-07-5 |
DC23753 |
CID888706
CID888706 is a small molecule, pan activator of Rho-family GTPases.. |
496775-95-2 |
DC20904 |
CIDD 0067106
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
2151865-39-1 |
DC11374 |
Cilastatin
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. |
82009-34-5 |
DC9325 |
Cilazapril (monohydrate)
Featured
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. |
92077-78-6 |
DC20341 |
Ciliobrevin D
Featured
Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking. |
1370554-01-0 |
DC9582 |
Cilomilast
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
153259-65-5 |
DC22028 |
Ciluprevir
Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively. |
300832-84-2 |
DC12134 |
Cimiside B
Cimiside B, a glycoside alkaloid, isolated from the rhizome of Cimicifuga dahurica. |
152685-91-1 |
DC20093 |
Cinchonine ((8R,9S)-Cinchonine; LA40221)
Featured
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. |
118-10-5 |
DC9896 |
Cinnarizine
Featured
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
298-57-7 |
DC21572 |
Cipemastat
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9). |
174265-38-4 |
DC9603 |
Ciprofibrate
Ciprofibrate is a peroxisome proliferator-activated receptor agonist. |
52214-84-3 |
DCAPI1372 |
Ciprofloxacin (Cipro)
Featured
Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. |
85721-33-1 |
DC9466 |
Ciproxifan (maleate)
Featured
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
184025-19-2 |
DC12100 |
Cirsimaritin
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities. |
6601-62-3 |
DC20342 |
cis Ned-19
cis Ned-19 is the stereoisomer of trans Ned-19, a chemical probe for the Ca(2+)-releasing second messenger NAADP. |
1137264-00-6 |
DC9517 |
Cisatracurium (besylate)
Featured
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. |
96946-42-8 |
DC20906 |
CJ-13610
Featured
CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM. |
179420-17-8 |
DC20907 |
CK 666
Featured
CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM). |
442633-00-3 |
DC20343 |
CK1-IN-3c
CK1-IN-3c is a novel casein kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 1.6 uM. |
756805-89-7 |
DC20344 |
CK2-IN-1
CK2-IN-1 is a potent, competitive inhibitor of ATP binding to Casein kinase 2(CK2) with IC50 of 9 nM, induces differentiation of epidermal progenitor cells to terminally differentiated keratinocytes with EC50 of 0.1 uM.. |
863598-09-8 |
DC11107 |
CKD-516
CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo. |
1188371-47-2 |
DC11098 |
CKD-519
CKD-519 (Rocacetrapib, CKD519) is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor, inhibits the CETP-mediated transfer of cholesteryl ester in human serum with IC50 of 2.3 nM. |
1402796-27-3 |
DC20847 |
CL 316243
CL 316243 (BTA 243) is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM. |
183720-02-7 |
DC20909 |
CL 316243 disodium
CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM. |
138908-40-4 |
DC20910 |
CL-82198 hydrochloride
CL-82198 is a potent, selective inhibitor of MMP-13 (89% inhibition at 10 ug/mL), displays no activity at MMP-1, MMP-9 and TACE, significantly reduces the migration of LS174 cells by 55% at 10 uM.. |
1188890-36-9 |
DC4205 |
Cladribine
Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
4291-63-8 |
DC12292 |
Cl-amidine hydrochloride
Featured
Cl-amidine (hydrochloride) is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9 μM for PAD4. |
1373232-26-8 |
DC9868 |
Clanfenur
Featured
Clanfenur is a substituted benzoylphenylurea and an analogue of the pesticide diflubenzuron with potential antineoplastic activity. |
51213-99-1 |
DC8937 |
Clarithromycin
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. |
81103-11-9 |
DC12407 |
Class I and IIB HDAC inhibitor 42
Class I and IIB HDAC inhibitor 42 is a novel potent, selective class I and IIB inhibitor (HDAC1 Ki=0.27 nM) for topical treatment of cutaneous t-cell lymphoma.. |
2245323-24-2 |
DC10204 |
Clinofibrate
Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. |
30299-08-2 |
DC10242 |
5-Chloro-8-hydroxy-7-iodoquinoline
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. |
130-26-7 |
DC21722 |
CLK-IN-T3
Featured
CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively. |
2109805-56-1 |
DC11004 |
CLK2 inhibitor Indazole1
CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases. |
|
DC23464 |
Clobenpropit
Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors. |
145231-45-4 |
DC23440 |
Clobenpropit dihydrobromide
Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors. |
145231-35-2 |
DC12304 |
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate)
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors. |
60789-62-0 |
DC8681 |
Clofentezine
Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females. |
74115-24-5 |
DC3147 |
Clopidogrel hydrogensulfate
Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent. |
120202-66-6 |
DC8672 |
Cloquintocet-mexyl
Cloquintocet-mexyl is a herbicide, used to control coarse annual grass of the family poaceae (gramineae). |
99607-70-2 |
DC7991 |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
Featured
Clozapine N-oxide is a major metabolite of Clozapine noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro. |
34233-69-7 |
DC12714 |
CLP-290
Featured
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257; In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior. |
1181083-81-7 |
DC11061 |
ClpP inhibitor M21
ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay. |
1151944-58-9 |
DC11067 |
CLSP37
CLSP37 (RIPK2 inhibitor CLSP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
|
DC11068 |
CLSP43
CLSP43 (RIPK2 inhibitor CLSP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
|
DC21063 |
CM03
CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM). |
2101208-44-8 |
DC12629 |
CM-675
CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively. |
1872466-47-1 |
DC20913 |
CMA-008
CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM). |
854091-96-6 |
DC23813 |
CMC2.24
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo. |
1255639-43-0 |
DC7388 |
c-Met inhibitor 1
c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. |
1357072-61-7 |
DC9617 |
CMK
CMK is a RSK2 kinase inhibitor. |
821794-90-5 |
DC21530 |
CMP-5
Featured
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
880813-42-3 |
DC21531 |
CMP-5 hydrochloride
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
1030021-40-9 |
DC23508 |
CMPD167
CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).. |
313994-79-5 |
DC22512 |
CMPDA
Featured
CMPDA is a potent positive allosteric modulator of GluR2 receptors with EC50 of 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assays. |
380607-77-2 |
DC12477 |
CN750
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM. |
2098711-72-7 |
DC9370 |
CNP-AFU
CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU). |
157843-41-9 |
DC7009 |
CNS-7056
CNS 7056 is a new short-acting sedative/anaesthetic that acts on GABAA receptors in the brain. |
308242-62-8 |
DC20346 |
CN-SAH
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.. |
1985669-27-9 |
DC12103 |
CNT2 inhibitor-1
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2. |
880155-70-4 |
DC23180 |
CNV1014802(Raxatrigine)
Featured
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo. |
934240-30-9 |
DC7104 |
CNX-1351
CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. |
1276105-89-5 |
DC7105 |
CNX-2006
Featured
CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR. |
1375465-09-0 |
DC24119 |
Cobimetinib racemate
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.. |
934662-91-6 |
DC22505 |
Cobimetinib R-enantiomer
Cobimetinib R-enantiomer (GDC-0973. |
934660-94-3 |
DC11081 |
Coblopasvir
Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection.. |
1312608-46-0 |
DC10430 |
COH29
COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with an IC50 of 8 μM in KB cell. |
1190932-38-7 |
DC22149 |
COH-SR4
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling. |
73439-19-7 |
DC23785 |
Col 003
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47. |
328565-16-8 |
DC7813 |
Collagen proline hydroxylase inhibitor
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents. |
223666-07-7 |
DC7608 |
OXi-4503
Combretastatin A1 diphosphate OXi4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. |
288847-35-8 |
DC11955 |
Takeda compound 101
Featured
Compound 101 (GRK2 inhibitor 101, Takeda compound 101, Cmpd101) is a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3. |
865608-11-3 |
DC10933 |
Compound 3-110-22
Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E. |
|
DC22270 |
Compound 621433144
Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity. |
2223169-38-6 |
DC22117 |
Compound 7004
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
|
DC11164 |
Compound 919278
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK, does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA). |
2189366-77-4 |
DC21345 |
Contezolid
Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL. |
1112968-42-9 |
DC11048 |
Contilisant
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM. |
2135615-68-6 |
DC12098 |
Corin
Featured
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. |
1808113-09-8 |
DC11104 |
Tildacerfont
Featured
corticotropin releasing factor (CRF) antagonist. |
1014983-00-6 |
DC22488 |
Corticotropin-releasing factor (human)
Featured
Corticotropin-releasing hormone (CRH) is a peptide hormone involved in the stress response.. |
86784-80-7 |
DC22479 |
Cortisone acetate
Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester. |
50-04-4 |
DC23908 |
Cortisone
Featured
Cortisone is a pregnane (21-carbon) steroid hormone, one of the main hormones released by the adrenal gland in response to stress. |
53-06-5 |
DC8694 |
Cortodoxone
Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone). |
152-58-9 |
DC9554 |
Cot inhibitor-1
Cot inhibitor-1 is a COT/Tpl2 inhibitor. |
915365-57-0 |
DC9555 |
Cot inhibitor-2
Cot inhibitor-2 is a COT/Tpl2 inhibitor. |
915363-56-3 |
DC20933 |
Cotylimide-VI
Cotylimide-VI (CTL-VI) is a small molecule that perturbs plant hormone strigolactone accumulation and inhibits hypocotyl growth.. |
419539-64-3 |
DC10363 |
Coumestrol
Featured
Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. |
479-13-0 |
DC21413 |
Cowanin
Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM. |
21044-85-9 |
DC8543 |
CP465022 HCl
CP 465022 hydrochloride is a selective GluR (AMPA) antagonist which is non-competitive. |
199655-36-2 |
DC23320 |
CP 31398 dihydrochloride
Featured
CP-31398 is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53. |
1217195-61-3 |
DC23610 |
CP-339818 hydrochloride
Featured
CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM. |
478341-55-8 |
DC23415 |
CP-481715
CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity and . |
212790-31-3 |
DC4132 |
CP-547632
Featured
CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). |
252003-65-9 |
DC8251 |
CP-724,714
CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. Phase 2. |
383432-38-0 |
DC8892 |
CP724714
CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2. |
537705-08-1 |
DC9317 |
CP-809101 (hydrochloride)
CP-809101 Hcl is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. |
1215721-40-6 |
DC9385 |
CPA inhibitor
CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). |
223532-02-3 |
DC23544 |
CPG-52364
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
1093135-60-4 |
DC7564 |
CPI 0610(Pelabresib)
Featured
CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay. |
1845726-14-8 |
DC8002 |
CPI-360 (R)
Featured
CPI-360 is a compound in design and preparation of wew palladium precatalysts for C-C and C-N cross-coupling reactions. |
1802175-06-9 |
DC10527 |
Ciforadenant (CPI-444)
Featured
CPI-444 is an orally administered antagonist of the adenosine A2A receptor. It is designed to block the action of adenosine that is produced by tumors. |
1202402-40-1 |
DC22874 |
CPI644
CPI644 is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.18 uM for CBP. |
1904647-34-2 |
DC20925 |
CPP-115
CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities. |
640897-20-7 |
DC10982 |
CPSI-1306
CPSI-1306 (CPSI1306) is an orally available small-molecule MIF antagonist, protects against UVB-induced squamous cell carcinoma, reduces the severity of animal model of multiple sclerosis.. |
1309793-47-2 |
DC22061 |
CPT157633
CPT157633 is a novel potent, selective PTP1B inhibitor with Ki of 40 nM, shows markedly less activities against a panel of 6 PTPs and 2 dual-specificity phosphatases. |
888213-72-7 |
DC10970 |
CPTH2
CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells. |
357649-93-5 |
DC10969 |
CPTH6 hydrobromide
CPTH6 hydrobromide is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor. |
|
DC10968 |
CPTH6
CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor. |
1099614-81-9 |
DC23765 |
CPYPP
Featured
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction. |
310460-39-0 |
DC12396 |
CR4056
Featured
CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM; increases norepinephrine (NE) tissue levels both in the rat cerebral cortex and lumbar spinal cord, shows ED50 of 5.8 mg/kg in CFA rat model of inflammatory pain; shows high effectivity against bortezomib-induced painful neuropathy in rats. |
1004997-71-0 |
DC11154 |
CR6086
CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
|
DC11380 |
Difelikefalin (CR845)
Featured
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2]. |
1024828-77-0 |
DC20347 |
Crebinostat
Featured
Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9; potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons; upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant. |
1092061-61-4 |
DC22208 |
cRIPGBM
cRIPGBM (RIPGBM derivative cRIPGBM, RIPGBM-18) is a metabolite of RIPGBM induces apoptosis in GBM CSCs (EC50=68 nM in GBM 1 cells) by interacting with RIPK2 (Kd=2.3 uM). |
|
DC21980 |
Crisdesalazine
Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro. |
927685-43-6 |
DC22634 |
Crizotinib hydrochloride
Featured
Crizotinib (PF-02341066;PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4 nM. |
1415560-69-8 |
DC20926 |
Cromoglicic acid
Cromoglicic acid is a mast cell stabilizer with anti-inflammatory activity that prevents the release of inflammatory chemicals such as histamine, leukotrienes from mast cells. |
16110-51-3 |
DC23299 |
CS3
CS3 is a potent, selective cIAP1 and cIAP2 inhibitor with IC50 of 16 nM and 85 nM respectively, shows no significant activity against XIAP (IC50>34 uM).. |
1207457-11-1 |
DC20999 |
CS-3150 (Esaxerenone;XL-550)
Featured
CS-3150 (Esaxerenone, XL-550) is a highly potent, selective and orally active non-steroidal mineralocorticoid receptor antagonist with IC50 of 9.4 nM; displays >1,000-fold selectivity over other steroid hormone receptors, glucocorticoid receptor, androgen receptor and progesterone receptor; inhibits aldosterone-induced transcriptional activation of human mineralocorticoid receptor with IC50 of 3.7 nM, shows superior potency to that of spironolactone and eplerenone; suppresses aldosterone-induced decrease in urinary Na(+)/K(+) ratio, inhibits blood pressure elevation induced by DOCA/salt-loading in rats. |
1632006-28-0 |
DC20651 |
CS-526
CS-526 (AKU 517. |
313272-12-7 |
DC20089 |
CSF1R-IN-1
Featured
CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit; has improved metabolic stability and Caco2 permeability. |
2095849-04-8 |
DC20348 |
CSIC E379
CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively. |
1220476-13-0 |
DC22209 |
CSLP37
Featured
CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
2244984-64-1 |
DC22210 |
CSLP43
CSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
2244988-80-3 |
DC20930 |
CSN5i-3
CSN5i-3 (CSN5 inhibitor 3) is a potent, selective and orally available inhibitor of CSN5 with IC50 of 5.8 nM, the proteolytic subunit of COP9 signalosome (CSN). |
|
DC12576 |
CSRM617
Featured
CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly. |
787504-88-5 |
DC22063 |
CSRM617 hydrochloride
CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly. |
1353749-74-2 |
DC20932 |
Conteltinib
CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo. |
1384860-29-0 |
DC22064 |
CTA056
CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (Itk) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM). |
1265822-30-7 |
DC22065 |
CTA095
CTA095 (CTA-095) is a potent Etk (BMX) and Src dual inhibitor with IC50 of 60 and 120 nM, respectively, shows no significant inhibition on Btk and Yes at 10 uM. |
1265823-05-9 |
DC11110 |
CTDP-32476
CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM. |
928046-68-8 |
DC22066 |
CTN06
CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively. |
|
DC23400 |
CTPB
CTPB is an anacardic acid derivative, was reported as a selective activator of p300 (KAT3B) HAT activity but not PCAF (KAT2B), which enhanced HAT-dependent transcriptional activation. |
586976-24-1 |
DC11217 |
SLC25A1 inhibitor CTPI-2
Featured
CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and |
68003-38-3 |
DC9510 |
CTS-1027
CTS-1027 is a potent small molecule inhibitor of MMPs(IC50=0.4 nM/0.6 nM for MMP2/MMP13); >1,000 fold selectivity over MMP1. |
193022-04-7 |
DC20934 |
CU239
CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM. |
946249-82-7 |
DC20952 |
CU-3
CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region. |
1815598-71-0 |
DC7544 |
CUDC-101
Featured
CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. |
1012054-59-9 |
DC23897 |
CUR-61414
CUR-61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM). |
334998-36-6 |
DC23726 |
Cuspin-1
Cuspin-1 is a small molecule upregulator of SMN (Survival of Motor Neuron protein) with EC50 of 18 uM. |
337932-29-3 |
DC12291 |
CVT-12012
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. |
1018675-35-8 |
DC20936 |
CWP-232228
CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus. |
|
DC11980 |
CX 4338
CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM. |
41609-06-7 |
DC24074 |
CX-546
Featured
CX546 is an AMPA receptor potentiator and GluR activator, binds specifically to the agonist bound non-desensitized receptor. |
215923-54-9 |
DC23632 |
CX-614
CX-614 is a positive allosteric modulator of AMPA receptors, shows neuroprotective effects for treatment of Parkinson's disease and Alzheimer's disease. |
191744-13-5 |
DC10203 |
CXCR2-IN-1
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. |
1873376-49-8 |
DC23524 |
CXCR2-IN-68
CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors. |
1838123-21-9 |
DC20349 |
CXL017
CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM. |
1063714-11-3 |
DC10775 |
Fadraciclib (CYC065)
Featured
CYC065 is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities. |
1070790-89-4 |
DC7325 |
CYC116
Featured
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM. |
693228-63-6 |
DC26110 |
Cyclapolin 1
Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases. |
736157-02-1 |
DC26115 |
Cyclapolin 9
Cyclapolin 9 is a potent, selective, and ATP-competitive polo-like kinase PLK1 inhibitor with IC50 of 500 nM.. |
40533-25-3 |
DC10368 |
Cyclo(his-pro)
Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone. |
53109-32-3 |
DC20657 |
Cyclocreatine Phosphate
Cyclocreatine Phosphate (AM 285) is an analog of the creatine kinase CKMT1 substrate creatine and inhibitor of the creatine biosynthesis pathway. |
18838-38-5 |
DC20350 |
Cyclopamine tartrate
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM. |
1178510-81-0 |
DC11214 |
Cyclophilin inhibitor C31
Cyclophilin inhibitor C31 (SMCypI C31) is a small-molecule cyclophilin (CypA) inhibitor (SMCypI) with PPIase inhibition IC50 of 0.1 uM, displays anti-HCV activity (HCV Gt1b replicon EC50=0.4 uM) and disrupts the CypA-NS5A interaction. |
|
DC20101 |
Cyclosporin A-Derivative 1 Free base
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin. |
286852-20-8 |
DC23630 |
Cyclothiazide
Cyclothiazide (Doburil) is a positive allosteric modulator of the AMPA and kainate receptors that potentiates AMPA-mediated glutamate currents. |
2259-96-3 |
DC20351 |
CYD-1-79
CYD-1-79 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM), potentiates 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2CR but not the 5-HT2AR cells.. |
1443281-47-7 |
DC23283 |
CYD-2-11
CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM). |
1425944-22-4 |
DC12469 |
CYH33
Featured
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
1494684-28-4 |
DC12470 |
CYH33 methanesulfonate
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
1494684-33-1 |
DC20352 |
CYP11B1-IN-25
CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2. |
2101952-78-5 |
DC5134 |
lexibulin (CYT997)
CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 1/2. |
917111-44-5 |
DC11199 |
CZh226
Featured
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1. |
2196199-00-3 |
DC11198 |
CZh226 hydrochloride
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1. |
2231440-94-9 |
DC9886 |
D-(+)-Cellobiose
D-(+)-Cellobiose is a substrate of β-glucosidase. |
528-50-7 |
DC12296 |
D-(+)-Trehalose dihydrate
Featured
D-(+)-Trehalose dihydrate can be used as a food ingredient and pharmaceutical excipient. |
6138-23-4 |
DC12252 |
D,L-Buthionine-(S,R)-sulfoximine
Featured
D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis. |
5072-26-4 |
DC12582 |
D13-9001
D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa.. |
957471-96-4 |
DC25001 |
D-156844
D156844 is a potent SMN2 inducer and DcpS inhibitor. |
1005501-84-7 |
DC12610 |
D159153
D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively.. |
|
DC11124 |
D-520
D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN. |
1619269-47-4 |
DC20053 |
D5D-IN-326
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and d |
1236767-85-3 |
DC9589 |
D609
Featured
D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. |
83373-60-8 |
DC11232 |
D715-2441
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM. |
54245-10-2 |
DC8913 |
Dabigatran etexilate mesylate
Featured
Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. |
872728-81-9 |
DC4197 |
Actinomycin D
Featured
Dactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. |
50-76-0 |
DC20353 |
Dafadine A
Featured
Dafadine A is the first reported small-molecule DAF-9 cytochrome P450 inhibitor that robustly induces dauer formation in in the nematode Caenorhabditis elegans. |
1065506-69-5 |
DC21469 |
Dagrocorat
Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.. |
1044535-52-5 |
DC3163 |
Dalcetrapib (JTT-705)
Featured
Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM. |
211513-37-0 |
DC22810 |
Damnacanthal
Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation. |
477-84-9 |
DC21881 |
Danicamtiv (MYK-491)
Featured
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. |
1970972-74-7 |
DC11082 |
Danicopan (ACH-4471)
Featured
Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM. |
1903768-17-1 |
DC12338 |
Dansylamide
Dansyl amide is a fluorescent dye that is used in biochemistry and chemistry to label substances with the fluorescent dansyl group. |
1431-39-6 |
DC8665 |
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ fro |
24868-20-0 |
DC20170 |
Dapagliflozin propanediol monohydrate
Featured
Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
960404-48-2 |
DC20941 |
DAPH-1
Featured
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture. |
145915-58-8 |
DC20354 |
DAPH-12
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM). |
145915-63-5 |
DC9630 |
Dapoxetine (hydrochloride)
Featured
Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI). |
129938-20-1 |
DC10259 |
Dapson
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. |
80-08-0 |
DC1050 |
Daptomycin
Featured
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
103060-53-3 |
DC3152 |
Darifenacin
Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9. |
133099-04-4 |
DC8908 |
Darunavir ethanolate
Featured
Darunavir ethanolate is an HIV protease inhibitor,showed potent activity against COVID-19(SARS-COV-2). |
635728-49-3 |
DC21381 |
Dasolampanel
Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine.. |
503294-13-1 |
DC9331 |
Daun02
Daun02 is a daunorubicin b-galactoside prodrug for use in conjunction. |
290304-24-4 |
DC7069 |
Daunorubicin HCL
Featured
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
23541-50-6 |