| DC11904 |
Olinciguat (IW-1701)
Featured
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Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. |
|
| DC22940 |
SKF-32802 |
A novel potent, selective hERG potassium channel (Kv11.1) activator that induces a leftward shift in the voltage dependence of activation.. |
|
| DC11854 |
IDX899 |
A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively. |
|
| DC21703 |
STAT5 inhibitor 17f
Featured
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A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation. |
|
| DC11497 |
IRAK4-IN-28 |
A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM. |
|
| DC22938 |
ICA-027243
Featured
|
A novel potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.. |
|
| DC22741 |
RY796 R-form |
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
| DC22744 |
RY796 racemate |
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
| DC12019 |
RY796 |
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
| DC11613 |
Mcl1-IN-26 |
A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays. |
|
| DC22886 |
TASP 0433864 |
A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
|
| DC20441 |
MAO-B inhibitor 8f |
A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM. |
|
| DC20467 |
mTOR inhibitor 10 |
A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM. |
|
| DC11985 |
PSTC |
A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity). |
|
| DC23862 |
MET inhibitor Compound 1 |
A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively. |
|
| DC22977 |
Lu AF-58027 |
A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
|
| DC11559 |
PDE5-IN-6c |
A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1. |
|
| DC11969 |
(S)-C33 |
A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
|
| DC11585 |
MZ-242 |
A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM. |
|
| DC11867 |
TBK1 PROTAC 1 |
A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε. |
|
| DC21458 |
(S)-PBMC |
A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8). |
|
| DC20951 |
DFL 23448 |
A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
|
| DC21747 |
tBPC |
A novel potent, selective Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
|
| DC22700 |
DETQ |
A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM. |
|
| DC11777 |
PDM-631 |
A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
|
| DC22857 |
Pyr-1 |
A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor. |
|
| DC23672 |
Gemigliptin
Featured
|
A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes. |
|
| DC20685 |
AS2795440 |
A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM). |
|
| DC20782 |
BI 689648 |
A novel potent, selective, orally active aldosterone synthase inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase. |
|
| DC11730 |
GNE-207 |
A novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM. |
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