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Cat. No.	Product Name	Field of Application
DC22673	SCH 486757	A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
DC21441	ONO-2952	A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO.
DC11536	Imigliptin dihydrochloride	A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
DC11631	INCB040093	A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM.
DC22740	RO 5126946	A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.
DC20690	ASP 2905 Featured	A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.
DC11547	LY-2562175 Featured	LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM.
DC11826	ASP-6537	A novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
DC11605	ONO-0300302	A novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM.
DC22600	HI-TOPK-032 Featured	A novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.
DC11553	FT-827	A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
DC23487	AS2575959	A novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo.
DC23450	SAS-1121	A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 16.2 nM, 574-fold selectivity over sigma 1 receptors..
DC23465	DKR-1051	A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM).
DC22370	Meptyldinocap	A novel powdery mildew (Erysiphe necator) fungicide that shows protectant and post-infective activities. .
DC22592	Amiselimod hydrochloride (MT-1303 hydrochloride) Featured	A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
DC11916	FD-5180 Featured	A novel protein kinase affinity probe...
DC11636	HMCEF	A novel P-selectin inhibitor that directly binds to P-selectin.
DC26112	SLMP53-1 Featured	SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
DC11917	(R)-OR-S1	A novel SAM-competitive, highly selective, orally bioavailable EZH1/2 dual inhibitor with IC50 of 16/50 nM, respectively.
DC25071	PDE6δ inhibitor 8	A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM..
DC23742	Rac1-IN-6	A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM.
DC23749	Rac1-IN-1	A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM.
DC21702	SC-99 Featured	A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src.
DC12010	ML116	A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).
DC12004	NS19504	A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
DC22660	Tenovin-D3	A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM.
DC11562	Sirt2-PROTAC-1	A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM)..
DC22961	ITP-2	A novel small molecule activator of Kv 11.1 (hERG) channel (216% over control at 3 uM for hERG1a activation).
DC22982	Aldi-6	A novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively.

Novel inhibitors

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