Cat. No. | Product name | CAS No. |
DC21491 |
PF-06751979
PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2. |
1818339-66-0 |
DC11111 |
PF-06764427
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM. |
1842371-08-7 |
DC21492 |
PF-06795071
PF-06795071 is a potent, selective, covalent Monoacylglycerol Lipase (MAGL) inhibitor with IC50 of 3 nM, >1,000-fold selectivity over FAAH. |
2075629-81-9 |
DC22755 |
PF-06807656
PF-06807656 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1a) inhibitor with IC50 of 61 nM for hROMK in patch-clamp assays. |
2213468-04-1 |
DC21493 |
PF-06815189
PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5. |
2218484-75-2 |
DC21480 |
PF-06815345
PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay. |
1900686-46-5 |
DC11116 |
PF-06827443
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM. |
2115022-67-6 |
DC11153 |
PF-06855800
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. |
|
DC22194 |
PF-06873600
Featured
PF-06873600 (PF06873600, PF 06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. |
2185857-97-8 |
DC21478 |
PF-06928215
Featured
PF-06928215 (PF06928215) is a high affinity Cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 200 nM, IC50 of 4.9 uM. |
2378173-15-8 |
DC21494 |
PF-152
PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM). |
1112169-64-8 |
DC23575 |
PF-184298
PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively. |
813447-40-4 |
DC22907 |
PF-219061
PF-219061 (PF 219061, PF219061) is a potent, selective agonist of dopamine D3 receptor with EC50 of 8 nM. |
710654-74-3 |
DC22421 |
PF-232798
PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity. |
849753-15-7 |
DC23267 |
PF-3450074
Featured
PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro. |
1352879-65-2 |
DC23449 |
PF-3635659
PF-3635659 (PF-03635659) is a potent, very long dissociative half-life (slow off-rate, >1440 min) muscarinic M3 antagonist with Ki of 0.2 nM, shows potential for the treatment of chronic obstructive pulmonary disease (COPD).. |
931409-24-4 |
DC22797 |
PF-3644022
Featured
PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM. |
1276121-88-0 |
DC8152 |
PF3845yne
PF3845yne is a Alkyne analogues of PF3845. |
1196109-53-1 |
DC21859 |
PF-3893787
PF-3893787 (ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM. |
943057-12-3 |
DC21473 |
PF-4363467
PF-4363467 (PF 04363467) is a novel highly potent, brain penetrant dopamine D3/D2 receptor antagonist with Ki of 1.3/692 nM respectively, with high selectivity for D3R versus other biogenic amine receptors. |
2040055-84-1 |
DC8526 |
PF4618433
Featured
PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. |
1166393-85-6 |
DC11808 |
PF-46396
PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein. |
1207481-21-7 |