Cat. No. | Product name | CAS No. |
DC10395 |
S107
Featured
S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels. |
927871-76-9 |
DC11030 |
S119-8
Featured
S119-8 is a novel broad spectrum inhibitor of influenza virus replication (IC50=1.43 nM) by targeting the viral Nucleoprotein (NP), with no detectable cytotoxicity (CC50>50 uM). |
443639-96-1 |
DC11255 |
S130
S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases. |
1160852-22-1 |
DC23578 |
S-18986
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors. |
175340-20-2 |
DC10392 |
S1p receptor agonist 1
S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2. |
1514888-56-2 |
DC24113 |
S1P1 Agonist 8
S1P1 Agonist 8 is a potent, selective, orally bioavailable S1P1 receptor agonist with EC50 of 35 nM (S1P1 internalization), >100-fold selectivity over against receptor subtypes S1P2-5. |
1324003-64-6 |
DC22398 |
S-2101
S-2101 is a potent lysine-specific demethylase 1 (LSD1) inhibitor with Ki of 0.61 uM. |
1239262-36-2 |
DC12622 |
S29434
Featured
S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1. |
874484-20-5 |
DC21602 |
S-3448
S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
254877-04-8 |
DC21603 |
S3I-M2001
S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers. |
1003580-86-6 |
DC23281 |
S44563
S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively. |
1044900-59-5 |
DC11176 |
S44819
S44819 (S 44819, Egis-13529) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
1398496-82-6 |
DC12279 |
S55746 hydrochloride (BLC201 (hydrochloride))
S55746 hydrochloride is a potent, orally active and selective BCL-2 inhibitor, with Kis and Kds of 1.3 nM, 520 nM and 3.9 nM, 186 nM for BCL-2 and BCL-XL, respectively. S55746 hydrochloride has antitumor activity. |
1448525-91-4 |
DC12163 |
S55746 (BLC201)
Featured
S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity[1]. |
1448584-12-0 |
DC10137 |
S63845
Featured
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM. |
1799633-27-4 |
DC8529 |
S6K-18
Featured
S6K-18 is a highly selective inhibitor of S6K1, with an IC50 of 52nM. |
1265789-88-5 |
DC8506 |
S-99
Featured
S-99 inhibits LPS-induced TNFa release assay in vivo |
1124381-69-6 |
DC20029 |
SA 47
SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate. |
792236-07-8 |
DC8444 |
Sabutoclax
Featured
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
1228108-65-3 |
DC4134 |
Safinamide
Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. |
133865-89-1 |
DC11684 |
sAJM-589
sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM. |
2089-82-9 |
DC22251 |
SAK3
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro. |
1256269-87-0 |