Cat. No. | Product name | CAS No. |
DC21252 |
Tezampanel
Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor. |
154652-83-2 |
DC8932 |
TG003
Featured
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. |
300801-52-9 |
DC7516 |
TG100-115
Featured
TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
677297-51-7 |
DC8511 |
TG-46
Featured
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3 with IC50 values of 6nM, 25nM, 17nM, 169nM respectively. |
936091-15-5 |
DC12506 |
TG8-69
Featured
TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM. |
|
DC8510 |
TG-89
Featured
TG-89 is a JAK inhibitor. It has IC50 values of 6, 25, 17 and 169 nM against JAK2, FLT3, RET and JAK3 respectively. |
936091-56-4 |
DC8652 |
TGR-1202 hydrochloride(Umbralisib)
TGR-1202 hydrochloride is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-78-0 |
DC8653 |
TGR-1202(Umbralisib)
Featured
TGR-1202 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-67-7 |
DC25110 |
TGR-1202 R-enantiomer
TGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.. |
1532533-69-9 |
DC7321 |
TGX221
Featured
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β . |
663619-89-4 |
DC21750 |
TH 5427
TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro. |
|
DC12564 |
TH-257
Featured
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay. |
2244678-29-1 |
DC26123 |
Thalidomide-O-amido-C3-NH2
Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
2022182-58-5 |
DC11749 |
THAL-SNS-032
Featured
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
2139287-33-3 |
DC12070 |
Thapsigargin
Thapsigargin is an inhibitor of microsomal Ca2+-ATPase. |
67526-95-8 |
DC20289 |
(1S,2S)-2-PCCA
The (1R,2R) diastereomer of 2-PCCA, a potent, selective agonist of the orphan GPR88 receptor with EC50 of 373 nM, 5-fold more potent than the (1S, 2S)-isomer.. |
1609624-97-6 |
DC23193 |
(S)-MCPG
The active isomer of (RS)-MCPG, an non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.. |
150145-89-4 |
DC23990 |
N-Desethyl Sunitinib
Featured
The active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor for the treatment of RCC and imatinib-resistant GIST.. |
356068-97-8 |
DC9947 |
RU43044
The antiglucocorticoid RU43044 exerted significant agonist activity and activated MMTV-Luc transcription in osteosarcoma cells but not human breast cancer cells. |
136959-96-1 |
DC24020 |
Calcium N5-methyltetrahydrofolate
The calcium salt of levomefolic acid that has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. . |
26560-38-3 |
DC21523 |
Pomstafib-1
The cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a. |
1688703-35-6 |
DC8509 |
Akt-I-1
Featured
The compound (Akt-I-1) inhibits only Akt1 (IC50 4.6 μM) and does not inhibit AKT2, or AKT3. |
473382-39-7 |