Home > Products > Novel inhibitors
Cat. No. Product name CAS No.
DC10055 Akt-I-1,2 HCl Featured

The compound (Akt-I-1,2) inhibited both Akt1 and Akt2 with IC50 values of 2.7 and 21 μM respectively.

473382-50-2
DC20956 DM-NOFD

The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

865488-53-5
DC20291 (S)-BRS-3 agonist Compound A

The distomer of BRS-3 agonist Compound A, shows no activity for bombesin receptor subtype-3 (BRS-3) with EC50>10 uM..

DC23959 Aliskiren Featured

The first in a class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM.

173334-57-1
DC20396 GPR4 antagonist 3b

The first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM).

1883333-94-5
DC11818 SCB-4380 Featured

SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.

915-67-3
DC11661 BAY 73-6691

BAY 73-6691 is a drug developed by Bayer for the treatment of Alzheimer's disease. It was the first compound developed that acts as a phosphodiesterase inhibitor selective for the PDE9A subtype.

794568-92-6
DC11947 ML418

The first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM.

1928763-08-9
DC11626 Sulfotransferase-IN-1

The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM .

2158198-77-5
DC11940 VU590

The first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.

313505-85-0
DC23116 (S)-GNE-140

The less active enantiomer of GNE-140, inhibits LDHA activity (18-fold less potent that (R)-GNE-140).

2003234-64-6
DC21410 Phortress

The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.

328087-38-3
DC24187 Calcifediol monohydrate Featured

The major circulating metabolite of vitamin D3.

63283-36-3
DC22687 (-)-U-50488 hydrochloride

The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects.

114528-79-9
DC23923 D-Glutamic acid Featured

The one form of glutamic acid found in nature, is the most potent natural inhibitor of glutathione synthesis.

6893-26-1
DC21777 Candoxatril

The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor..

123122-55-4
DC21061 GPA 512

The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.

1808115-35-6
DC23916 Human growth hormone-releasing factor Featured

Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.

83930-13-6
DC21524 Pomstafib-2

The pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.

DC23007 AUDA-BE

The prodrug of AUDA, a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 50 nM and 100 nM for mouse sEH and human sEH, respectively.

776300-37-9
DC25073 Cidofovir dihydrate

The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases.

149394-66-1
DC24002 Adrafinil Featured

The prodrug of modafinil that is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention..

63547-13-7
Page 261 / Total 1557 FirstPrevNextLastGoto