| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23435 | AM-6226 | AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM. |
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| DC8886 | Iodopravadoline(AM-630) Featured | AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively. |
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| DC11552 | AM-6538 | AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.. |
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| DC9447 | AM679 | AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. |
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| DC11221 | AM9405 | AM9405 (AM-9405) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively. |
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| DC8623 | AM966 Featured | AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
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| DC8958 | Amantadine HCl | Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. |
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| DC10372 | Amcasertib(BBI503) Featured | Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases. |
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| DC5056 | AMD3465 Featured | AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
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| DC20792 | Amelubant | Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.). |
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| DC10621 | Amenamevir Featured | Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. |
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| DC7356 | Ametantrone Featured | Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation. |
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| DC8618 | AMG-319 Featured | AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
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| DC11239 | AMG-333 Featured | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
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| DC7055 | AMG517 Featured | AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
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| DC12002 | AMG 580 | AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM. |
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| DC9457 | AMG 837 (calcium hydrate) | AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
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| DC7867 | AMG-837 Featured | AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
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| DC6310 | AMG 853(AMG853;Vidupiprant) | AMG 853 is novel a CRTH2 and DP Dual Antagonist. |
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| DC9366 | AMG 900 Featured | AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
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| DC8397 | AMG 925 Featured | AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell. |
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| DC5083 | Cinacalcet (AMG-073) HCl Featured | AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
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| DC20660 | AMG-076 | AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM). |
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| DC8514 | AMG-1 Featured | AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively. |
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| DC20661 | AMG-1694 | AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly. |
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| DC7056 | AMG-208 Featured | AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
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| DC9793 | AMG232 | AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells . |
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| DC8845 | AMG337 Featured | AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
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| DC10101 | AMG-3969 Featured | AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM. |
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| DC23850 | AMG-458(AMG458;AMG 458) | AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met). |
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