| DC9974 |
Isturisa (Osilodrostat)
Featured
|
Osilodrostat is an inhibitor of aldosterone synthase and aromatase, for treating Cushing’s disease. |
|
| DC11438 |
Osimertinib analogue
Featured
|
Osimertinib analogue (C-005) is a potent EGFR inhibitor, which is 2-5 fold more selective than Osimertinib between above EGFR mutants and wild-type EGFR(A431) cells. |
|
| DC21449 |
OSMI-1
Featured
|
OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM. |
|
| DC12453 |
OSMI-4 |
OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM. |
|
| DC10658 |
OSS-128167(SIRT6-IN-1)
Featured
|
OSS-128167 is a novel SIRT6 inhibitor. |
|
| DC8248 |
Ostarine(MK-2286)
Featured
|
Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism. |
|
| DC7220 |
OSU-03012
Featured
|
OSU-03012(AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
|
| DC22304 |
ILK-IN-2 (CPD 22: OSU-T315 analog)
Featured
|
ILK-IN-2 (OSU-T315 analog) is a ILK inhibitor. |
|
| DC21450 |
OSW-1
Featured
|
OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively. |
|
| DC9443 |
Otamixaban |
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
|
|
| DC7109 |
Otenabant (CP-945598 free base)
Featured
|
Otenabant (CP945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. |
|
| DC9501 |
Otilonium (bromide) |
Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.
|
|
| DC11257 |
OTS186935
Featured
|
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model. |
|
| DC11256 |
OTS193320
Featured
|
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM. |
|
| DC8043 |
OTS514
Featured
|
OTS-514 is a novel TOPK(PDZ binding kinase; PBK) inhibitor. IC50:2.6nM |
|
| DC7723 |
OTS964， OTS 964
Featured
|
OTS964 is a novel TOPK(T–lymphokine-activated killer cell–originated protein kinase) inhibitor. |
|
| DC8732 |
OTSSP167
Featured
|
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
|
| DC7475 |
OTSSP167 HCl
Featured
|
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
|
| DC12312 |
OTX008 (Calixarene 0118; PTX008)
Featured
|
OTX008 is a selective inhibitor of galectin-1. |
|
| DC7150 |
Birabresib (OTX015)
Featured
|
OTX-015 is a new potent BRD2/3/4 inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors. |
|
| DC11022 |
OUL35
Featured
|
OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family. |
|
| DC11023 |
OUL35 derivative 32 |
OUL35 derivative 32 is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of230 nM, rescues HeLa cells from ARTD10-induced cell death.. |
|
| DC22719 |
OUP-16 |
OUP-16 is a potent H4R agonist with a considerable selectivity over H3R.. |
|
| DC23553 |
o-vanillin |
o-vanillin (C29L. |
|
| DC21022 |
OX-14 |
OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite. |
|
| DC8676 |
Oxadiazon |
Oxadiazon is a preemergent herbicide. |
|
| DC5885 |
Oxaliplatin
Featured
|
Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff |
|
| DC10480 |
Oxamflatin
Featured
|
Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM). |
|
| DC9001 |
Oxcarbazepine |
Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. |
|
| DCAPI1236 |
Oxfendazole |
Oxfendazole |
|
