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Cat. No. Product name CAS No.
DC8383 Dp44mT Featured

Dp44mT is a potent iron chelator, which shows selective antitumor activity.

152095-12-0
DC23775 DPA-714

DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.

958233-07-3
DC20966 DPM-1001 Featured

DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor.

1471172-27-6
DC20366 DRAK2-IN-16

DRAK2-IN-116 is a potent, selective DRAK2 inhibitor with IC50 of 3 nM, shows weak inhibition for DRAK1 (IC50=51 nM) and no significant activity against DAPK1/2/3 (IC50>1 uM)..

871837-60-4
DC20103 D-Ribose(mixture of isomers) Featured

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation

50-69-1
DC20967 DRI-C21045

DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays.

2101765-81-3
DCAPI1562 Drospirenone Featured

Drospirenone is a synthetic progestogen exhibiting antiandrogenic and antimineralocorticoid activity.

67392-87-4
DC2056 Droxidopa (L-DOPS,SM-5688) Featured

Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

23651-95-8
DC12598 DRV1 (GPR32) agonist C2A

DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively.

862811-76-5
DC20968 DS-1040

DS-1040 (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

1335138-62-9
DC20969 DS-1040 tosylate

DS-1040 tosylate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

1335138-89-0
DC20970 DS-1040 tosylate hydrate

DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

1335138-90-3
DC20974 DS16570511

DS16570511 is a cell-permeable inhibitor of the mitochondrial calcium uniporter (MCU) that inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 uM.

DC20975 DS-2330 Featured

DS-2330 is a phosphorous lowering agent for treating hyperphosphatemia in chronic kidney disease..

1634680-81-1
DC20971 DS-2969b

DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.

2092352-48-0
DC12410 8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine Featured

DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.

DC22082 DS-437 Featured

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.

1674364-87-4
DC12411 DS-6930 Featured

DS-6930 (DS 6930, DS6930) is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%; significantly recruits several cofactors, such as RIP140 and PGC1, in cofactor recruitment assays; demonstrateshigh PPARγ agonist potency with robust plasma glucose reduction, maintains diminished PPARγ-related adverse effects upon toxicological evaluation in vivo, and demonstrated no hepatotoxicity.

1242328-82-0
DC22083 DS-6930b

DS-6930b (DS-6930 calcium salt) is the calcium salt of DS-6930, which is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%.

DC20976 DS-7423 Featured

DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR  respectively.

1222104-37-1
DC20973 DS86760016

DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS).

1853176-89-2
DC22081 DS88790512 hydrochloride

DS88790512 is a potent, selective, and orally bioavailable blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM)..

DC22080 DS88790512

DS88790512 is a potent, selective, and orally bioavailable blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM)..

DC12193 Ds-HAPP

Ds-HAPP is an anthrancenyl and dansyl fluorophore ligand.

330163-26-3
DC12643 DSP-0565

DSP-0565 (DSP0565) is a new drug candidate with broad anti-convulsant activity, does not bind to any GABA-A binding sites, may be caused as the result of its GABAergic function via novel target..

1226855-28-2
DC20977 DSP-1053

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.

1176326-78-5
DC26008 DSP2230 Featured

DSP-2230 is a selective Nav1.7/Nav1.8 blocker.

1233231-30-5
DC20979 DSP-6952 hydrobromide

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

1184661-33-3
DC20980 DT204

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.

428497-71-6
DC20367 dTRIM24 Featured

dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).

2170695-14-2
DC12473 Dual BRM and BRG1 inhibitor 14

Dual BRM and BRG1 inhibitor 14 is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.

DC3148 Duloxetine Featured

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

116539-59-4
DC3149 Duloxetine hydrochloride

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

136434-34-9
DC12054 Duocarmycin TM

Duocarmycin TM is an exceptionally potent antitumor antibiotic.

157922-77-5
DC8825 Dutasteride Featured

Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT).

164656-23-9
DC10805 DWK-1339 Featured

DWK-1339|DWK1339|cas 1018946-38-7

1018946-38-7
DC7405 DY131 Featured

DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.

95167-41-2
DC20368 Dynarrestin Featured

Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis.

2222768-84-3
DC7406 Dynasore Featured

Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin.

304448-55-3
DC20905 Dynein2-IN-37

Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM).

1823133-56-7
DC8396 Dyngo-4a Featured

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.

1256493-34-1
DC20369 Dynole 34-2

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.

1128165-88-7
DC20985 E 6201

E 6201 (E6201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM.

603987-35-5
DC20986 E 6446 Featured

E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.

1219925-73-1
DC10895 E260 Featured

E260 is a Fer/FerT kinase inhibitor.

1241537-79-0
DC20370 E3 Ligand-Linker Conjugate 1

E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC.

2098488-36-7
DC22335 E3 ligase Ligand 1A Featured

E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL)

1948273-02-6
DC12674 E3 ligase Ligand-Linker Conjugates 16 Featured

E3 ligase Ligand-Linker Conjugates 16 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

1799711-25-3
DC12675 E3 ligase Ligand-Linker Conjugates 17 Featured

E3 ligase Ligand-Linker Conjugates 17 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

1950635-16-1
DC8404 E3330 Featured

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

136164-66-4
DC23442 E-5842

E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.

177945-46-9
DC23416 E-5842 hydrochloride

E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.

177945-45-8
DC9387 E-64 Featured

E-64 is a natural, potent, and irreversible inhibitor of cysteine proteases; IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively.

66701-25-5
DC10520 E6446 dihydrochloride Featured

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

1345675-25-3
DC10126 E-64c Featured

E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus.

76684-89-4
DC23728 E64FC26

E64FC26 is a highly potent pan-style inhibitor of Protein Disulfide Isomerase (PDI) with IC50 of 1.9 uM (PDIA1), also inhibits all other members of the PDI family, including PDIA3, PDIA4, TXNDC5, and PDIA6.

2285446-62-8
DC23360 E67-2

E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.

1364914-62-4
DC21898 E7090 succinate

E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM).

1879965-80-6
DC22085 E7090

E7090 (E 7090) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM).

1622204-21-0
DC11062 E7107

E7107 (E-7107) is a derivative of pladienolide that targets the SF3b subunit of the spliceosome, shows significant antitumor activity in vitro and in vivo.

630100-90-2
DC10784 E7820 Featured

E7820 is an angiogenesis inhibitor by suppressing integrin a2, a cell adhesion molecule expressed on endothelial cells.

289483-69-8
DC11037 EB-3D

EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with IC50 of 1.0 uM (purified ChoKα1), strongly impairs cell proliferation in a variety of different cancer cell lines.

1839150-63-8
DC20989 EBI-1051

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.

1801896-05-8
DC23818 EBI-907

EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.

1581764-31-9
DC9848 Ebselen Featured

Ebselen is a selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase.

60940-34-3
DC20123 EC0489

EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-drug conjugate (SMDC).

1096702-14-5
DC10277 EC330 Featured

EC330 is a leukemia inhibitory factor (LIF) inhibitor.

2016795-77-8
DC10980 EC-359

EC-359 (EC359) is a first-in-class, orally available inhibitor of leukemia inhibitory factor (LIF), blocks LIF-LIFR interaction and binds to LIFR with affinity of 81 nM in SPR assay.

2012591-09-0
DC20990 EC-70124

EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM).

1185908-92-2
DC26057 Ecabet (sodium salt) Featured

Ecabet is an antiulcerative and gastroprotective agent.

86408-72-2
DCAPI1162 Ecdysone

Ecdysone

3604-87-3
DCAPI1408 Echinocandin B0

Echinocandin B0

150283-04-8
DC9912 Echinocystic acid Featured

Echinocystic acid  a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, has potent antioxidant, anti-inflammatory and anti-tumor properties.

510-30-5
DCAPI1126 Econazole nitrate (Spectazole)

Econazole nitrate (Spectazole)

24169-02-6
DC21514 Ecopladib

Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively.

381683-92-7
DCAPI1380 Edaravone (MCI-186)

Edaravone (MCI-186)

89-25-8
DC21002 Edelfosine Featured

Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells.

77286-66-9
DC23562 Edivoxetine

Edivoxetine (LY2216684) is a novel potent, selective norepinephrine reuptake inhibitor (NERI) being evaluated as adjunctive treatment for major depressive disorder (MDD)..

1194508-25-2
DC23628 Edivoxetine hydrochloride

Edivoxetine (LY2216684) is a novel potent, selective norepinephrine reuptake inhibitor (NERI) being evaluated as adjunctive treatment for major depressive disorder (MDD)..

1194374-05-4
DC10762 Edonerpic maleate Featured

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

519187-97-4
DC7819 Efaproxiral sodium Featured

Efaproxiral Sodium is a synthetic allosteric modifier of hemoglobin, used for brain metastases originating from breast cancer.

170787-99-2
DC9772 Efinaconazole(KP-103) Featured

Efinaconazole(KP-103) is a novel triazole antifungal drug currently under development as a topical treatment for onychomycosis.

164650-44-6
DC21515 Efipladib

Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.

381683-94-9
DC10261 Eflornithine hydrochloride hydrate

Eflornithine(Difluoromethylornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.

96020-91-6
DC11379 Efpeglenatide

Efpeglenatide is a new once-2eekly GLP-1 Injection for Type 2 Diabetes

1296200-77-5
DC20992 eFT226

eFT226 is a novel, potent and selective eIF4A inhibitor with anti-tumor activity in B-cell malignancies, promotes eIF4A binding to specific mRNA sequences and interferes with the assembly of the eIF4F initiation complex.

DC22086 EG00229 free base

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM.

1018927-63-3
DC22087 EG01377

EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.

2227996-00-9
DC12303 Eg5 Inhibitor V, trans-24

Eg5 Inhibitor V, trans-24 is a potent and specific Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.

869304-55-2
DC23179 EGF816 mesylate

EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively.

1508250-72-3
DC23677 Eggmanone

Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway.

505068-32-6
DC7728 EHop-016 Featured

EHop-016 is a novel inhibitor of Rac GTPase with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3.

1380432-32-5
DC7627 EHT-1864 Featured

EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.

754240-09-0
DC11287 EHT 5372 Featured

EHT 5372 is a novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.

1425945-63-6
DC7930 EI-1

EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.

1418308-27-6
DC12233 Eicosadienoic acid Featured

Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.

2091-39-6
DC20371 eIF4A3 inhibitor 53a

eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM.

2095486-67-0
DC20062 eIF4A3-IN-2

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

2095677-20-4
DC9684 EL102 Featured

EL-102 is a dual-inhibitor of apoptosis and angiogenesis, and exerts its action though the inhibition of Hif1 alpha induced hypoxic signalling pathways and induction of the Caspase 3/7 apoptotic cascade.

1233948-61-2
DC10208 Elacestrant S enantiomer

Elacestrant S enantiomer is an low activity enantiomer of elacestrant. Elacestrant (RAD1901) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.

DC10032 Elagolix sodium Featured

Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist.

832720-36-2
DC7407 Elagolix Featured

Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist.

834153-87-6
DC22394 Elaiophylin

Elaiophylin (Gopalamicin.

37318-06-2
DC22182 Elatol

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.

55303-97-4
DC9295 Elbasvir(MK-8742) Featured

Elbasvir (MK-8742) is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.

1370468-36-2
DCAPI1410 Eldecalcitol Featured

Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is more efficaci

104121-92-8
DC9980 Eleclazine(GS-6615) Featured

Eleclazine(GS-6615) is a selective late sodium current inhibitor.

1443211-72-0
DC21774 Eletriptan

Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist.

143322-58-1
DC9291 Eliglustat hemitartrate (Genz-112638) Featured

Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.

928659-70-5
DC9290 Eliglustat(Genz-99067) Featured

Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.

491833-29-5
DC7786 ELN 441958 Featured

ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor.IC50 value: 0.26 nM (Ki)Target: B1 Receptorin vitro: ELN-441958 is a novel small molecule bradykinin B1 receptor antagonist, based on the inhibition of agonist-induced increases in intracellular calcium in native and recombinant cells. ELN-441958 does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM, showing that it is highly selective for B1 over B2 receptors. ELN-441958 also displays good selectivity for B1 over other receptors examined in a broad screening panel. It is >500-fold and >2000-fold selective for the B1 receptor over the human μ- and δ-opioid receptor, the most potent off-target activity identified. In IMR-90 cells expressing the native human B1 receptor, ELN-441958 produced a concentration-dependent antagonism of the DAKD-induced calcium mobilization with a KB of 0.12 nM. [1]in vivo: ELN-441958 is essentially completely absorbed and produces high plasma levels after oral administration in rhesus monkeys.ELN-441958 has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. ELN-441958 has high oral exposure and moderate plasma half-lives in rats and rhesus monkeys. The oral availability of ELN441958 in rats was 57%. ELN-441958 dose-dependently reduced carrageenan-induced thermal hyperalgesia in a rhesus monkey tail-withdrawal model, with an ED50 3 mg/kg s.c. [1]

913064-47-8
DC10740 ELN484228 Featured

ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease.

312-63-0
DC7779 ELND0006

ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease.

1333990-84-3
DCAPI1504 Elocalcitol

Elocalcitol

199798-84-0
DC20268 ELQ300 Featured

ELQ300 is a novel inhibitor of the mitochondrial cytochrome bc1 complex (complex III in the electron transport chain).

1354745-52-0
DCAPI1196 Eltrombopag (SB-497115-GR) Featured

Eltrombopag (SB-497115-GR)

496775-61-2
DC8369 Eltrombopag olamine Featured

Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.

496775-62-3
DC23523 Elubrixin tosylate

Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

960495-43-6
DC21618 Elubrixin

Elubrixin (SB-656933, GSK-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

688763-64-6
DC8625 Eluxadoline Dihydrochloride Featured

Eluxadoline Dihydrochloride is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist.

864825-13-8
DC4235 Elvitegravir(GS9137) Featured

Elvitegravir (EVG) is a drug used for the treatment of HIV infection. It acts as an integrase inhibitor.

697761-98-1
DC21465 EMA300

EMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor, produces analgesia in rodent model of neuropathic pain..

136676-76-1
DC10870 EMA400 Featured

EMA400 is a potent and highly selective AT2R antagonist.

152362-51-1
DC7731 Emapunil(AC-5216) Featured

Emapunil(AC-5216;XBD-173) is a translocator protein

226954-04-7
DC7117 EMD534085

EMD534085 is a kinesin inhibitor currently in clinical development.

858668-07-2
DC9620 EMD638683 Featured

EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM.

1181770-72-8
DC8885 EMICORON Featured

EMICORON is a novel G-quadruplex (G4) ligand showing high selectivity for G4 structures over the duplex DNA, causing telomere damage and inhibition of cell proliferation in transformed and tumor cells.

1422423-23-1
DC9771 ACU4429,ACU 4429,ACU-4429 Featured

Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM.

1141934-97-5
DC10314 Emixustat

Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.

1141777-14-1
DC22785 EML-405

EML-405 (EML405) is a small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 14 uM.

2101954-79-2
DC5018 Empagliflozin (BI-10773) Featured

Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), which is found almost exclusively in

864070-44-0
DC23171 Empesertib(BAY 1161909) Featured

Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM.

1443763-60-7
DC12273 EMT inhibitor-1

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

1638526-21-2
DC23108 EN460 Featured

EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM).

496807-64-8
DC24204 EN6 Featured

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases.

1808714-73-9
DC20892 Enadoline

Enadoline (CI 977.

124378-77-4
DCAPI1334 Enalapril maleate (Vasotec)

Enalapril maleate (Vasotec)

76095-16-4
DC8403 Endoxifen (Z-isomer hydrochloride) Featured

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

1032008-74-4
DC7589 Eniporide(EMD96785) Featured

Eniporide is a The Na(+)/H(+) exchange inhibitor.

176644-21-6
DC20993 ENMD-1068 Featured

ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling.

789488-77-3
DC9247 AP-III-a4 hydrochloride Featured

ENOblock Hcl(AP-III-a4 Hcl) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo.

2070014-95-6
DC7119 ENO block(AP-III-a4) Featured

ENOblock(AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo.

1177827-73-4
DC8778 Enocitabine

Enocitabine is an anti-tumor agent and an antineoplastic. A derivative of Cytarabine.

55726-47-1
DC20018 Enocyanin Featured

Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity.

11029-12-2
DC8321 Entacapone Featured

Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

130929-57-6
DC4208 Entecavir Monohydrate Featured

Entecavir hydrate belongs to the family of medicines called antivirals.

209216-23-9
DC8881 Entecavir

Entecavir is a deoxyguanosine nucleoside analogue with antiviral activity against the hepatitis B virus (HBV).

142217-69-4
DC24202 Ent-kaurene Featured

Ent-kaurene is a tetracyclic diterpene consisting of ent-kaurane, where the 6-methyl group is replaced by methylene. It derives from a hydride of an ent-kaurane.

562-28-7
DC21856 Enviroxime

Enviroxime (Zinviroxime.

72301-79-2
DC20848 Enzaplatovir

Enzaplatovir (BTA-585, BTA-C585) is an orally bioavailable RSV fusion protein inhibitor for the treatment of respiratory syncytial virus infections..

1323077-89-9
DC20950 EOAI3402143

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor with increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.

1699750-95-2
DC21601 Epertinib

Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively.

908305-13-5
DC20374 EphB3-IN-1

EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM.

1980036-18-7
DC11433 Vatiquinone

EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone.

1213269-98-7
DC8693 Epiandrosterone Featured

Epiandrosterone is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase from the adrenal hormone DHEA.

481-29-8
DC9363 Epibrassinolide

Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor c

78821-43-9
DC23071 Epigoitrin Featured

Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix, exhibit in vitro cooperation, they have in vitro anti-virus activity.

1072-93-1
DCAPI1014 Eplerenone Featured

Eplerenone, also known as Inspra and CGP-30083, is a selective aldosterone receptor antagonist used to treat hypertension and congestive heart failure. Eplerenone provides marked protection against vascular injury in the kidney and heart.

107724-20-9
DC23786 Epolactaene

Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.

167782-17-4
DC7120 Epothilone A

Epothilone A is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.

152044-53-6
DC7012 Epothilone D

Epothilone D(Desoxyepothilone B; KOS 862) is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum.

189453-10-9
DC8030 Epoxomicin Featured

Epoxomicin is a selective and irreversible inhibitor of 20S proteasome with an IC50 value of 4 nM.

134381-21-8
DC12311 Eprobemide (LIS 630) Featured

Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A.

87940-60-1
DC9171 Eprosartan mesylate

Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

144143-96-4
DC5182 EPZ004777 Featured

EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.

1338466-77-5
DC7121 EPZ005687 Featured

EPZ-005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.

1396772-26-1
DC26000 EPZ019997 Featured

EPZ019997 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)).

1628925-77-8
DC12529 EPZ020411 dihydrochloride

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).

2095432-47-4
DC23134 EPZ020411 hydrochloride

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).

2070015-25-5
DC20996 EPZ 025654

EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM.

1888328-89-9
DC22657 EPZ-030456

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.

1808011-23-5
DC7122 Tazemetostat(EPZ-6438) Featured

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity with Ki value of 2.5±0.5 nM.

1403254-99-8
DC8595 Equisetin

Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity.

57749-43-6
DC20997 ER000444793 Featured

ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.

792957-74-5
DC22468 ER-27319 maleate

ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk.

1204480-26-1
DC22090 ER-464195-01

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5.

859218-37-4
DC22433 ER-819762

ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.

1155773-15-1
DC7410 Erastin Featured

Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.

571203-78-6
DC11238 ERD03

ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.

DCAPI1365 Erdosteine

Erdosteine

84611-23-4
DC21416 ERGi-USU

ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.

1147-56-4
DC23055 Erianin Featured

Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

95041-90-0
DC22441 Eritoran tetrasodium

Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist..

185954-98-7
DC26018 ERK5-IN-2 Featured

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.

1888305-96-1
DC22486 Erlotinib mesylate Featured

Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

248594-19-6
DCAPI1477 Ertapenem Featured

Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz.

153832-46-3
DCAPI1476 Ertapenem Sodium Featured

Ertapenem Sodium

153773-82-1
DC7409 E-Mycin

Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.

114-07-8
DC20244 ES9-17 Featured

ES9-17 is a novel CME inhibitor.

55854-43-8
DC10211 Escin

Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).

6805-41-0
DC21000 ESI-05 Featured

ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM.

5184-64-5
DC8443 ESI-09 Featured

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.

263707-16-0
DC9565 Eslicarbazepine (acetate)

Eslicarbazepine acetate (BIA 2-093) is an antiepileptic drug.

236395-14-5
DC12325 Eslicarbazepine (BIA 2-194)

Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.

104746-04-5
DCAPI1423 Esomeprazole

Esomeprazole

119141-88-7
DCAPI1487 Esomeprazole(magnesium)

Esomeprazole(magnesium)

161973-10-0
DC10714 Esonarimod (KE-298) Featured

Esonarimod (KE-298) is a new antirheumatic drug.

101973-77-7
DC23056 esperamicin A1 Featured

Esperamicin A1 is an enediyne antitumor antibiotics of bacterial origin.

99674-26-7
DCAPI1200 Estradiol

Estradiol

50-28-2
DC9440 Estropipate Featured

Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.

7280-37-7
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