| DC11387 |
Erdafitinib
Featured
|
Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1-4 with IC50 values of 1.2, 2.5, 3.0 and 5.7nM, respectively. |
|
| DCAPI1365 |
Erdosteine |
Erdosteine |
|
| DC21416 |
ERGi-USU |
ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. |
|
| DC23055 |
Erianin
Featured
|
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis. |
|
| DCAPI1539 |
Eribulin Mesylate
Featured
|
Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin is also known as E7389 and ER-086526, and also carries the US NCI designation NSC-707389. It is used to treat certain patients with breast cancer and liposarcoma. |
|
| DCAPI1516 |
Eribulin |
Eribulin Mesylate (E7389 Mesylate), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. |
|
| DC22441 |
Eritoran tetrasodium |
Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist.. |
|
| DC26018 |
ERK5-IN-2
Featured
|
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. |
|
| DC22486 |
Erlotinib mesylate
Featured
|
Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. |
|
| DC2101 |
Erlotinib free base
Featured
|
Erlotinib (OSI-744; NSC 718781; R1415) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
|
| DC3139 |
Erlotinib hydrochloride
Featured
|
Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM. |
|
| DCAPI1477 |
Ertapenem
Featured
|
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz. |
|
| DCAPI1476 |
Ertapenem Sodium
Featured
|
Ertapenem Sodium |
|
| DC8440 |
Erythromycin Cyclocarbonate
Featured
|
Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. |
|
| DC7409 |
E-Mycin |
Erythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
|
| DC20244 |
ES9-17
Featured
|
ES9-17 is a novel CME inhibitor. |
|
| DC10211 |
Escin |
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). |
|
| DC4171 |
Escitalopram oxalate
Featured
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
|
| DC21000 |
ESI-05
Featured
|
ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM. |
|
| DC8443 |
ESI-09
Featured
|
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
|
| DC9565 |
Eslicarbazepine (acetate) |
Eslicarbazepine acetate (BIA 2-093) is an antiepileptic drug.
|
|
| DC12325 |
Eslicarbazepine (BIA 2-194) |
Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. |
|
| DCAPI1423 |
Esomeprazole |
Esomeprazole |
|
| DCAPI1487 |
Esomeprazole(magnesium) |
Esomeprazole(magnesium) |
|
| DC10714 |
Esonarimod (KE-298)
Featured
|
Esonarimod (KE-298) is a new antirheumatic drug. |
|
| DC23056 |
esperamicin A1
Featured
|
Esperamicin A1 is an enediyne antitumor antibiotics of bacterial origin. |
|
| DCAPI1200 |
Estradiol |
Estradiol |
|
| DC9440 |
Estropipate
Featured
|
Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis. |
|
| DC3162 |
Eszopiclone |
Eszopiclone is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. |
|
| DC7770 |
Etamicastat |
Etamicastat is a novel dopamine β-hydroxylase inhibitor |
|
