Novel enhancer of the religation reaction of human topoisomerase I

Partial agonist at the glutamate binding site of the GluN2 subunits

Pesticide, acting as antibiotics or growth regulators to kill mites and ticks

Potent and selective inhibitor of Pim 1, inhibiting the phosphorylation of Bad and 4EBP1 in cells and suppresses the proliferation of several non-solid and solid human tumor cell lines.

Novel broad-spectrum β-lactamase inhibitor

Novel Biased modulator of NMDA receptors, controlling channel opening and ion selectivity

Novel negative allosteric modulator (NAM) of NMDA receptors, reducing both the overall current that flows following receptor activation and the flux of Ca2+ ion relative to monovalent cations

Scavenger for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide

The first plant cyclic peptide with antibacterial and antifungal activity

Novel potent gamma-secretase modulator

Novel GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions

Novel partial positive allosteric GABAA receptor modulator

Novel ALK5 inhibitor

Novel glucagon-like peptide 1 (GLP-1) receptor agonist, displaying significantly elongated half-lives and improved long-acting antidiabetic activity in the presence of endogenous anti-DNP antibodies

Potent and selective SIRT1 inhibitor

Potent and selective SIRT1 inhibitor

Topoisomerase I inhibitor

Novel Dual-Analyte Fluorescent Chemosensor for Visualizing Neurotransmitter Exocytosis

Novel potent MCT1 inhibitor, exhibiting good single agent anticancer efficacy properties

Polyethylene glycol conjugate of SN38, acting as a topoisomerase I inhibitor,, exerting significant anti-leukaemia activity, overcoming ABCG2-mediated topotecan resistance

Novel influenza A hemagglutinin (HA) fusion inhibitor (EC 50 = 1.9 ± 0.3 μM), preventing HA from transitioning to the postfusion state at pH 5.0

Novel antifungal agent against Candida albicans persister cells