Cat. No. | Product name | CAS No. |
DC11633 |
TAK-243
Featured
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
1450833-55-2 |
DC7057 |
TAK-285
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. |
871026-44-7 |
DC10923 |
TAK-615
Featured
TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
1664335-55-0 |
DC21280 |
TAK-659 free base(Mivavotinib)
Featured
TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM. |
1312691-33-0 |
DC8880 |
Orteronel (TAK-700)
TAK-700 shows potent inhibitory activity against rat, monkey, and human steroid 17,20-lyase inhibitor with IC50 of 54 nM, 27 nM, and 38 nM, respectively. |
426219-53-6 |
DC7304 |
TAK 715
TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
303162-79-0 |
DC20048 |
TAK-828F
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent ROR isoforms selectivity (>5000-fold selectivity aga |
1854901-94-2 |
DC11370 |
TAK-901
TAK-901 is a non-selective Aurora kinase inhibitor (IC50s = 3.1, 10, and 4.2 nM for Aurora A, B, and C, respectively). |
934541-31-8 |
DC21653 |
Simurosertib (TAK-931)
Featured
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
1330782-76-7 |
DC10065 |
Takeda-6d
Featured
Takeda-6d has potent inhibitory activity in both B-RAF with an IC50 of 7.0 nM and VEGFR2 with an IC50 of 2.2 nM. |
1125632-93-0 |
DC23153 |
Talabostat
Talabostat (PT-100, Val-boroPro) is a potent, nonselective, orally available inhibitor of post-proline cleaving serine proteases with Ki of 0.18 nM for DPP4, also potently inhibits DPP8/9 (IC50=1.5/0.76 nM), FAP, DPP2 and some other DASH family enzymes. |
149682-77-9 |
DC8739 |
Talabostat mesylate
Talabostat mesilate(PT-100; Val-boroPro) is an orally active, specific inhibitor of dipeptidyl peptidases(IC50=1 nM for DPP4), including tumor-associated fibroblast activation protein. |
150080-09-4 |
DC12349 |
TAME hydrochloride
TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
1784-03-8 |
DC7310 |
Tamibarotene(Am-80)
Featured
Tamibarotene(Am-80) is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. |
94497-51-5 |
DC23853 |
TAM-IN-1
TAM-IN-1 is a highly potent, macrocyclic inhibitor of Mer and Axl with Ki of <50 pM and 130 pM, respectively.. |
1454847-05-2 |
DC21957 |
Taminadenant
Taminadenant is an adenosine receptor A2a antagonist.. |
1337962-47-6 |
DC9096 |
Tamoxifen
Featured
Tamoxifen(ICI-46474) is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. |
10540-29-1 |
DC7894 |
Tandutinib(MLN518)
Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2. |
387867-13-2 |
DC7769 |
Tanomastat
Tanomastat is an angiogenesis and Matrix Metalloproteinase inhibitor |
179545-77-8 |
DC23815 |
TAO Kinase inhibitor 1
Featured
TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models. |
850467-66-2 |
DC23809 |
TAOK inhibitor 63
TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively. |
850467-91-3 |
DC21732 |
TAP-311
TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM. |
1149362-88-8 |