| DC12176 |
NFAT Transcription Factor Regulator
Featured
|
NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM. |
|
| DC11171 |
NFEPP |
NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4. |
|
| DC23081 |
NFPS |
NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2. |
|
| DC8076 |
NG 52 (Compound 52 )
Featured
|
NG 52 (Compound 52) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM). |
|
| DC21380 |
NGD-4715 |
NGD-4715 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1), has anxiolytic, antidepressant and anorectic effects.. |
|
| DC11281 |
NGI-1 (ML414)
Featured
|
NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM. |
|
| DC11200 |
NGI-1 derivative C-19 |
NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A. |
|
| DC11462 |
NH-125
Featured
|
NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. |
|
| DC9758 |
NI-57
Featured
|
NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. |
|
| DC8836 |
NIBR189
Featured
|
NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). |
|
| DC8525 |
NIBR-17
Featured
|
NIBR-17 is a pan class I PI3K inhibitor with IC50 values of 1, 9.2, 9 and 20 nM respectively for PI3Kapha - delta. |
|
| DC21742 |
NIBR-3049 |
NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.. |
|
| DC9796 |
Nicainoprolhe(Nicainoprol)
Featured
|
Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias. |
|
| DC7977 |
Nicaraven
Featured
|
Nicaraven is an antivasospastic substance. |
|
| DC9170 |
Nicardipine hydrochloride |
Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. |
|
| DC25090 |
Nicardipine |
Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.. |
|
| DC9068 |
Niclosamide |
Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication. |
|
| DC8969 |
Nicorandil |
Nicorandil is potassium channel activator. |
|
| DC21243 |
Nidufexor（LMB-763）
Featured
|
Nidufexor (LMB763, LMB-763) is a novel potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders. |
|
| DC9079 |
Nifedipine |
Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action. |
|
| DC10114 |
Nifenalol
Featured
|
Nifenalol is a beta-adrenoceptor antagonist. |
|
| DCAPI1571 |
Nifuratel |
Nifuratel |
|
| DC12297 |
Nigakinone |
Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu. |
|
| DC10028 |
NIH-12848
Featured
|
NIH-12848 (NCGC00012848-02) is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, |
|
| DC10927 |
NIK inhibitor 4f(NIK SMI1)
Featured
|
NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice. |
|
| DC3144 |
Nilotinib
Featured
|
Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM. |
|
| DC4192 |
Nilutamide |
Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. |
|
| DC9379 |
Nilvadipine |
Nilvadipine(FR34235) is a calcium channel blocker for treatment of hypertension.
|
|
| DC9052 |
Nimesulide |
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. |
|
| DC9131 |
Nimodipine |
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. |
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