| DC7758 |
Nimorazole
Featured
|
Nimorazole is a nitroimidazole anti-infective. |
|
| DC7084 |
Nintedanib (BIBF 1120)
Featured
|
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
|
| DC8608 |
BIBF 1120 esylate
Featured
|
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
|
| DC9108 |
Nisoldipine |
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
|
| DCAPI1251 |
Nitazoxanide (Alinia, Annita)
Featured
|
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). |
|
| DC7791 |
NITD 609 |
NITD 609 is a novel and potent drug
candidate for the treatment of
uncomplicated malaria |
|
| DC21383 |
NITD-304 |
NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv. |
|
| DC21384 |
NITD-349 |
NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv. |
|
| DC21385 |
NITD-564 |
NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb. |
|
| DC21386 |
NITD-916 |
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb. |
|
| DC9561 |
Nitisinone
Featured
|
Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.
|
|
| DC9085 |
Nitrendipine |
Nitrendipine is a calcium channel blocker with marked vasodilator action. |
|
| DC21388 |
NJK14047 |
NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation. |
|
| DC20916 |
NKH 477 hydrochloride
Featured
|
NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase. |
|
| DC9786 |
NKP-1339
Featured
|
NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a phase I clinical trial. |
|
| DC9520 |
NKP608 |
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. |
|
| DC8021 |
Indoximod (NLG-8189)
Featured
|
NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2) |
|
| DC5172 |
NLG919(GDC-0919)
Featured
|
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
|
| DC26132 |
NLRP3 Inflammasome Inhibitor I |
NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome. |
|
| DC22177 |
NLY01 |
NLY01 (NLY-01, GLP1R agonist NLY01) is a potent, brain-penetrant long-acting GLP1R agonist, protects against the loss of dopaminergic neurons and behavioral deficits in the α-synuclein preformed fibril (α-syn PFF) mouse model of sporadic Parkinson's disea |
|
| DC11134 |
NMac1 |
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM. |
|
| DC20105 |
NMDAR antagonist 1
Featured
|
NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist. |
|
| DC8829 |
Betahistine EP Impurity C(NSC19005)
Featured
|
N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes. |
|
| DC12351 |
NMI 8739 |
NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. |
|
| DC7212 |
NMS-873
Featured
|
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP). |
|
| DC9936 |
NMS-P118
Featured
|
NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo. |
|
| DC21390 |
NMS-P293 |
NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2. |
|
| DC23556 |
NMS-P645 |
NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively. |
|
| DC8445 |
NMS-P937 (NMS1286937)
Featured
|
NMS-P937 (NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Phase 1. |
|
| DC21224 |
NMT1 inhibitor B13 |
NMT1 inhibitor B13 (LCL4) is a myristoylCoA analog that acts as a small molecule inhibitor of NMT1 with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane. |
|
