| DC21391 |
NNC 05-2090 hydrochloride
Featured
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NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM. |
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| DC22893 |
NNC-0640 |
NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM. |
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| DC21392 |
NNC-711
Featured
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NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM. |
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| DC11386 |
NNZ-2591
Featured
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NNZ2591 (cyclo-L-glycyl-L-2-allylproline)1 is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability, and oral bioavailability. |
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| DCAPI1187 |
Nobiletin (Hexamethoxyflavone)
Featured
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Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis. |
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| DC4204 |
Nocodazole
Featured
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Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies. |
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| DC9930 |
NOD-IN-1
Featured
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NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively. |
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| DC4111 |
Nolatrexed (AG-337)
Featured
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Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displ |
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| DC12198 |
N-Oleoyl glycine |
N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte. |
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| DC10549 |
Nomifensine maleate
Featured
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Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder. |
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| DC8178 |
Beclabuvir(BMS-791325) |
non-nucleoside inhibitor of the NS5B |
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| DC9342 |
Noopept |
Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
|
|
| DCAPI1558 |
Oxiracetam |
Nootropic agent shown to exhibit learning and memory improvement and cognitive function impairment prevention. Mechanism of action has not been quantified, but current theories suggest a modulation of glutamatergic and cholinergic neurotransmissions with |
|
| DC9037 |
Norethindrone |
Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone. |
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| DC9579 |
Nortadalafil
Featured
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Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
IC50 value:
Ta |
|
| DC8848 |
Nosiheptide |
Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces. |
|
| DC11016 |
NOSO-502 |
NOSO-502 (NOSO502) is a novel inhibitor of bacterial translation, has MIC values of 0.5-4 ug/ml against standard Enterobacteriaceae strains and carbapenem-resistant Enterobacteriaceae (CRE) isolates that produce KPC, AmpC, or OXA enzymes and metallo-β-lactamases. |
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| DC26002 |
TOPK inhibitor-1
Featured
|
Novel PDZ binding kinase (PBK) inhibitor. |
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| DC26003 |
(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one Hydrochloride
Featured
|
Novel PDZ binding kinase (PBK) inhibitor. |
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| DC8583 |
Asenapine Maleate
Featured
|
Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8 |
|
| DC10453 |
NP-118809
Featured
|
NP-118809 is a N-type calcium channel blocker. |
|
| DC11212 |
NP161 |
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM. |
|
| DC22179 |
NPD13668 |
NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels. |
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| DC22180 |
NPD8733
Featured
|
NPD8733 (NPD-8733) is a small-molecule ligand of valosin-containing protein (VCP)/p97, binds to the D1 domain of VCP/p97. |
|
| DC4136 |
NPS-2143 HCL |
NPS 2143 hydrochloride is a selective CaSR (Ca2+-sensing receptor) inhibitor and antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM. NPS 2143 hydrochlori |
|
| DC8398 |
NPS-1034
Featured
|
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. |
|
| DC60813 |
NPS-2143(SB 262470A ) |
NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. |
|
| DC21928 |
NPT 200-11
Featured
|
NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor. |
|
| DC9999 |
NQ301
Featured
|
NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. |
|
| DC8787 |
NQDI-1
Featured
|
NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. |
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