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Cat. No. Product name CAS No.
DC7211 Neratinib (HKI-272) Featured

Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.

698387-09-6
DC11550 Netazepide

Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.

155488-25-8
DC9019 Nevirapine

Nevirapine is a potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of HIV-1 infection and AIDS.

129618-40-2
DC9796 Nicainoprolhe(Nicainoprol) Featured

Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias.

76252-06-7
DC9170 Nicardipine hydrochloride

Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.

54527-84-3
DC3144 Nilotinib Featured

Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM.

641571-10-0
DC7084 Nintedanib (BIBF 1120) Featured

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.

656247-17-5
DC8608 BIBF 1120 esylate Featured

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.

656247-18-6
DC9108 Nisoldipine

Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

63675-72-9
DC7791 NITD 609

NITD 609 is a novel and potent drug candidate for the treatment of uncomplicated malaria

1193314-23-6
DC9520 NKP608

NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

177707-12-9
DC8021 Indoximod (NLG-8189) Featured

NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2)

110117-83-4
DC9936 NMS-P118 Featured

NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo.

1262417-51-5
DC8178 Beclabuvir(BMS-791325)

non-nucleoside inhibitor of the NS5B

958002-33-0
DC8583 Asenapine Maleate Featured

Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8

85650-56-2
DC4136 NPS-2143 HCL

NPS 2143 hydrochloride is a selective CaSR (Ca2+-sensing receptor) inhibitor and antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM. NPS 2143 hydrochlori

324523-20-8
DC7214 NPS-2143(SB 262470A )

NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively.

284035-33-2
DC8183 Paritaprevir(Veruprevir ABT-450) Featured

NS3/4A protease inhibitor

1216941-48-8
DC9486 Nucleozin Featured

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.

341001-38-5
DC4174 NVP-AEW541 Featured

NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.

475489-16-8
DC4118 NVP-BEP800 Featured

NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM.

847559-80-2
DC3133 NVP-BGT226 (BGT226) Featured

NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM.

1245537-68-1
DC7303 NVP-TAE684 Featured

NVP-TAE684(TAE684) is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.

761439-42-3
DC4237 NXY-059 (Cerovive)

NXY-059 (Cerovive) is an EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively.

168021-79-2
DC10807 O304 Featured

O304 is a novel AMPK activator.

1261289-04-6
DC10134 Obicetrapib (AMG-899,TA-8995) Featured

Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy.

866399-87-3
DC12298 Octreotide acetate (SMS 201-995 (acetate)) Featured

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

79517-01-4
DC6401 Odanacatib (MK 0822) Featured

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively.

603139-19-1
DC8700 ODM-201(Darolutamide) Featured

ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.

1297538-32-9
DC9583 Oglemilast

Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.

778576-62-8
DC11096 Olacaftor

Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..

1897384-89-2
DC4110 AZD-2281 (Olaparib) Featured

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively.

763113-22-0
DCAPI1464 Olmesartan

Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction.

144689-24-7
DC9179 Olmesartan MedoxoMil

Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive.

144689-63-4
DC10384 Olodaterol Featured

Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.

868049-49-4
DC9248 Olodaterol(BI-1744) hydrochloride Featured

Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs.

869477-96-3
DC8390 Oltipraz Featured

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

64224-21-1
DC10299 Olumacostat glasaretil

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

1261491-89-7
DC12281 Olutasidenib (FT-2102) Featured

Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 that could be used in the treatment of acute myeloid leukemia.

1887014-12-1
DC10324 Omapatrilat

Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.

167305-00-2
DC7023 Ombrabulin Featured

Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.

181816-48-8
DC10054 Ombrabulin hydrochloride Featured

Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.

253426-24-3
DC11044 Omidenepag Isopropyl Featured

Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma.

1187451-19-9
DC10043 ONO4059 hydrochloride Featured

ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.

1439901-97-9
DC8358 ONO-4059(Tirabrutinib) Featured

ONO-4059 is a novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase.

1351636-18-4
DC11905 Opiranserin

Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM).

1441000-45-8
DC2010 Oprozomib (ONX-0912) Featured

Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.

935888-69-0
DC10394 Org-26576

Org 26576 is a AMPA receptor positive allosteric modulator.

100044-96-0
DC11203 ORIC-101 Featured

ORIC-101 (ORIC101) is a highly potent, selective steroidal glucocorticoid receptor (GR) antagonist (IC50=5.6 nM) with reduced androgen receptor (AR) agonistic activity.

2222344-98-9
DC23149 Oseltamivir acid

Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate) is a potent inhibitor of influenza neuraminidase (NA) with Ki of <1 nM for both A and B strains,showed potent activity against COVID-19(SARS-COV-2).

187227-45-8
DCAPI1594 Oseltamivir phosphate Featured

OSELTAMIVIR is an active (orally) inhibitor of the influenze virus neuraminidase and converted to the active acid metabolite in vivo.

204255-11-8
DC1006 OSI-027 Featured

OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.

936890-98-1
DC4105 Linsitinib(OSI-906) Featured

OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.

867160-71-2
DC7219 OSI 930 Featured

OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl.

728033-96-3
DC8248 Ostarine(MK-2286) Featured

Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism.

841205-47-8
DC7220 OSU-03012 Featured

OSU-03012(AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067.

742112-33-0
DC9443 Otamixaban

Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.

193153-04-7
DC7109 Otenabant (CP-945598 free base) Featured

Otenabant (CP945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM.

686344-29-6
DC8732 OTSSP167 Featured

OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like).

1431697-89-0
DC7475 OTSSP167 HCl Featured

OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like).

1431698-10-0
DC5885 Oxaliplatin Featured

Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff

61825-94-3
DC8281 Ozanimod (RPC1063) Featured

Ozanimod (RPC1063) is a selective S1P1R modulator

1306760-87-1
DC10399 PAC-14028

PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

1005168-10-4
DC11113 Padsevonil

Padsevonil (UCB-0942, UCB0942) is a potential anti-seizure agent that functions as a pre- and post-synaptic inhibitor..

1294000-61-5
DC10292 Pagoclone

Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders.

133737-32-3
DC8717 PAK4-IN-1(KPT9274) Featured

PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay.

1643913-93-2
DC8469 Palbociclib Featured

Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

571190-30-2
DC5067 Palbociclib (PD0332991 HCl) Featured

Palbociclib is an oral, small molecule cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, now in Phase 3 clinical development for advanced breast cancer.

827022-32-2
DC7970 ACT058362 (Palosuran) Featured

Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.

540769-28-6
DC9681 Pamapimod(R-1503) Featured

Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor.

449811-01-2
DC7183 Panobinostat(LBH589) Featured

Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell.

404950-80-7
DC9876 Pantoprazole

Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

102625-70-7
DC9135 Pantoprazole Sodium

Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

138786-67-1
DC10255 Parecoxib

Parecoxib is a selective COX2 inhibitor.

198470-84-7
DCAPI1503 PARECOXIB SODIUM

PARECOXIB SODIUM

198470-85-8
DC6577 Paricalcitol

Paricalcitol

131918-61-1
DC10893 Parimifasor Featured

Parimifasor is an immunomodulator, with anti-inflammatory activity.

1796641-10-5
DC9098 Paroxetine HCl Featured

Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).

110429-35-1
DC9776 Pazopanib Hydrochloride Featured

Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

635702-64-6
DC2600 Pazopanib Featured

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit.

444731-52-6
DC11100 PBI-4050 sodium

PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

1254472-97-3
DC11099 PBI-4050

PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

1002101-19-0
DC9723 PBTZ169 Featured

PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor.

1377239-83-2
DC11770 PC786 Featured

PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.

1902114-15-1
DC1106 PCI-32765 (Ibrutinib) Featured

PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

936563-96-1
DC10531 PCO371 Featured

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1.

1613373-33-3
DC7224 PD 123319 Featured

PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

136676-91-0
DC1056 PD0325901 (Mirdametinib) Featured

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.

391210-10-9
DC8168 Peficitinib(ASP015K,JNJ-54781532) Featured

Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.

944118-01-8
DC7225 Pelitinib (EKB-569; WAY-EKB 569) Featured

Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM.

257933-82-7
DC11360 Pemafibrate Featured

Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis.

848259-27-8
DC8149 Pemetrexed disodium Featured

Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

150399-23-8
DCAPI1121 Peramivir

Peramivir

229614-55-5
DCAPI1010 Peramivir Trihydrate Featured

Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. Peramivir was approved to treat influenza infection in adults.

1041434-82-5
DC7226 Perampanel(E2007) Featured

Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.

380917-97-5
DC2021 Perifosine (KRX-0401) Featured

Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM.

157716-52-4
DC10529 PF 05089771 Featured

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

1235403-62-9
DC8259 PF0477736 Featured

PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity

952021-60-2
DC11664 PF-00446687 hydrochloride

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

862282-10-8
DC11665 PF-00446687

PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

862281-92-3
DC3168 PF-562271 PHSO3H SALT Featured

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

939791-38-5
DC7059 PF-03758309 Featured

PF-03758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity.

898044-15-0
DC7081 PF-04217903 Featured

PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).

956905-27-4
DC8353 PF-04418948 Featured

PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).

1078166-57-0
DC11367 PF-04447943 Featured

PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.

1082744-20-4
DC7027 Glasdegib(PF-04449913) Featured

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor

1095173-27-5
DC7227 PF-04620110 Featured

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

1109276-89-2
DC3108 PF-04971729 (Ertugliflozin) Featured

PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus.

1210344-57-2
DC9915 PF04995274,PF 04995274 Featured

PF-04995274 is a 5-HT4 receptor partial agonist. It thought to act centrally as a pro-cognitive agent that being developed for the treatment of Alzheimer's disease (AD).

1331782-27-4
DC10050 PF05175157 Featured

PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively.

1301214-47-0
DC11937 PF 05180999 Featured

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

1394033-54-5
DC11734 PF-06263276

PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

1421502-62-6
DC10631 PF-06273340

PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively.

1402438-74-7
DC10500 PF-06282999 Featured

PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.

1435467-37-0
DC11466 PF-06409577 Featured

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

1467057-23-3
DC11722 PF-06459988

PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

1428774-45-1
DC7924 PF06463922(Lorlatinib) Featured

PF06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.

1454846-35-5
DC10779 PF-06651600 Featured

PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM.

1792180-81-4
DC12488 PF-06700841 tosylate Featured

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

2140301-96-6
DC10022 PF06840003 Featured

PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.

198474-05-4
DC2047 Crizotinib (PF-2341066) Featured

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.

877399-52-5
DC7201 PF-2545920(MP-10) Featured

PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.

898562-94-2
DC1091 PF-299804 (Dacomitinib,PF-00299804) Featured

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

1110813-31-4
DC7480 PF-3274167(cligosiban) Featured

PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.

900510-03-4
DC3169 PF-562271 Featured

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

717907-75-0
DC10451 PFK158 Featured

PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies.

1462249-75-7
DC8335 PQR-309(Bimiralisib) Featured

PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell.

1225037-39-7
DC10728 Pibrentasvir(ABT-530) Featured

Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.

1353900-92-1
DC10047 PIM-447 dihydrochloride Featured

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.

1820565-69-2
DC9815 Pimodivir(VX-787) Featured

Pimodivir(VX-787) is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. 

1629869-44-8
DC10012 Pirmenol hydrochloride Featured

Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.

61477-94-9
DC9465 Pitolisant (hydrochloride) Featured

Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).

903576-44-3
DC7634 PKC-412 (Midostaurin) Featured

PKC-412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

120685-11-2
DC7238 Gedatolisib(PKI-587) Featured

PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively.

1197160-78-3
DC10016 Pleconarilis Featured

Pleconarilis is a picornavirus replication inhibitor.

153168-05-9
DC5055 Plerixafor (AMD3100) Featured

Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

110078-46-1
DC8741 Plerixafor octahydrochloride Featured

Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

155148-31-5
DC8158 Pexidartinib(PLX3397) Featured

PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.

1029044-16-3
DC1071 Vemurafenib (PLX4032) Featured

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

918504-65-1
DC6301 PLX-4720 Featured

PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

918505-84-7
DC10786 PLX51107 Featured

PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation.

1627929-55-8
DC11373 Polmacoxib

Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII.

301692-76-2
DC9742 Ponesimod Featured

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.

854107-55-4
DCAPI1093 Posaconazole Featured

Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

171228-49-2
DC11914 Poseltinib Featured

Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM.

1353552-97-2
DC7704 Poziotinib Featured

Poziotinib, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

1092364-38-9
DC7280 Pracinostat(SB939) Featured

Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I.

929016-96-6
DC9359 Pralatrexate Featured

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog.

146464-95-1
DC8970 Pramipexole Base

Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

104632-26-0
DC3151 Pramipexole dihydrochloride

Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.

104632-25-9
DCAPI1305 Pramiracetam

Pramiracetam

68497-62-1
DCAPI1473 Pregabalin Featured

Pregabalin

148553-50-8
DC9902 PRIMA-1 Featured

PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.

5608-24-2
DC10070 PRIMA-1MET(APR-246) Featured

PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity.

5291-32-7
DC10641 PRN1371 Featured

PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.

1802929-43-6
DC6903 Lapaquistat Acetate (TAK-475)

Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.

189060-13-7
DC4121 PSI6130 Featured

PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents.

817204-33-4
DC10464 PT2385 Featured

PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity.

1672665-49-4
DC7992 PX 12 Featured

PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.

141400-58-0
DC7486 PX-478 2HCL Featured

PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells.

685898-44-6
DCAPI1553 Pyrimethamine

Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(Pgp) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux

58-14-0
DC7664 Quarfloxin (CX-3543) Featured

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity.

865311-47-3
DC5197 Quizartinib (AC220) Featured

Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2.

950769-58-1
DC11138 Guanabenz acetate

R15A inhibitor.

23256-50-0
DC2068 R547

R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively.

741713-40-6
DC9462 R-7128(Mericitabine) Featured

R-7128(Mericitabine) is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes.

940908-79-2
DC9841 Fostamatinib(R788) Featured

R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

901119-35-5
DC1013 R788 disodium (Fostamatinib) Featured

R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.

1025687-58-4
DC9513 Radafaxine (hydrochloride) Featured

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulat

106083-71-0
DC5049 RAF265 (CHIR-265) Featured

RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf.

927880-90-8
DC8930 Rafoxanide

Rafoxanide is a salicylanilide used as an antiparasitic agent.

22662-39-1
DC9479 Raltegravir (potassium salt)

Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.

871038-72-1
DCAPI1581 Raltegravir Featured

Raltegravir Salt is a potent human immunodeficiency virus (HIV) integrase inhibitor and a novel anti-AIDS drug.

518048-05-0
DC8940 Raltitrexed Featured

Raltitrexed(ZD1694), an inhibitor of thymidylate synthase, is an antimetabolite drug used in cancer chemotherapy.

112887-68-0
DC9162 Ranolazine HCl Featured

Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).

95635-56-6
DC1048 Rapamycin (Sirolimus) Featured

Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. -

53123-88-9
DC8175 Rapastinel(GLYX-13) Featured

Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site.

117928-94-6
DC8190 Ravidasvir hydrochloride (PPI-668) Featured

Ravidasvir(PPI-668) is a NS5A Inhibitor.

1303533-81-4
DC7808 Refametinib (BAY86-9766) Featured

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

923032-37-5
DC9777 Regorafenib monohydrate(BAY 73-4506) Featured

Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

1019206-88-2
DC1030 Regorafenib (BAY73-4506,Fluoro-Sorafenib) Featured

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

755037-03-7
DC10441 Relebactam Featured

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes.

1174018-99-5
DC10463 Repotrectinib(TPX-005) Featured

Repotrectinib(TPX-005) is a multi-target macrocycle inhibitor of anaplastic lymphoma kinase (ALK), c-ros proto-oncogene 1 receptor tyrosine kinase (ROS1), and neurotrophic tyrosine kinase receptor (TRK)

1802220-02-5
DC7261 Resminostat hydrochloride (4SC-201)

Resminostat(RAS2410; 4SC-201) is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.

1187075-34-8
DC4148 Retapamulin

Retapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.

224452-66-8
DC10191 RG7800

RG7800 a small molecule SMN2 splicing modifier to enter human clinical trials to treat spinal muscular atrophy.

1449598-06-4
DC8185 Verosudil(AR-12286)

Rho-kinase (ROCK) inhibitor

1414854-42-4
DCAPI1165 Ribavirin (Copegus) Featured

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza.

36791-04-5
DCAPI1325 Rifabutin (Mycobutin)

Rifabutin (Mycobutin)

72559-06-9
DC7265 Rigosertib Featured

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.

1225497-78-8
DC7266 Rilpivirine(R 278474, TMC 278) Featured

Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

500287-72-9
DC7268 Risperidone(R 64 766)

Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM).

106266-06-2
DC9475 Ritonavir Featured

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS,showed potent activity against COVID-19(SARS-COV-2) .

155213-67-5
DC5108 BAY 59-7939 (Rivaroxaban) Featured

Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.

366789-02-8
DCAPI1435 Rivastigmine tartrate

Rivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and Parkinson's disease.

129101-54-8
DC5146 RN486 Featured

RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor.

1242156-23-5
DC9454 Ro 28-1675

Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.

300353-13-3
DC9666 Ro 46-2005 Featured

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

150725-87-4
DC7933 Ro 48-8071 fumarate Featured

Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.

189197-69-1
DC8215 RO4929097 Featured

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.

847925-91-1
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