Cat. No. | Product name | CAS No. |
DC7211 |
Neratinib (HKI-272)
Featured
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
698387-09-6 |
DC11550 |
Netazepide
Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM. |
155488-25-8 |
DC9019 |
Nevirapine
Nevirapine is a potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of HIV-1 infection and AIDS. |
129618-40-2 |
DC9796 |
Nicainoprolhe(Nicainoprol)
Featured
Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias. |
76252-06-7 |
DC9170 |
Nicardipine hydrochloride
Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. |
54527-84-3 |
DC3144 |
Nilotinib
Featured
Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM. |
641571-10-0 |
DC7084 |
Nintedanib (BIBF 1120)
Featured
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
656247-17-5 |
DC8608 |
BIBF 1120 esylate
Featured
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
656247-18-6 |
DC9108 |
Nisoldipine
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
63675-72-9 |
DC7791 |
NITD 609
NITD 609 is a novel and potent drug candidate for the treatment of uncomplicated malaria |
1193314-23-6 |
DC9520 |
NKP608
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. |
177707-12-9 |
DC8021 |
Indoximod (NLG-8189)
Featured
NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2) |
110117-83-4 |
DC9936 |
NMS-P118
Featured
NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo. |
1262417-51-5 |
DC8178 |
Beclabuvir(BMS-791325)
non-nucleoside inhibitor of the NS5B |
958002-33-0 |
DC8583 |
Asenapine Maleate
Featured
Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8 |
85650-56-2 |
DC4136 |
NPS-2143 HCL
NPS 2143 hydrochloride is a selective CaSR (Ca2+-sensing receptor) inhibitor and antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM. NPS 2143 hydrochlori |
324523-20-8 |
DC7214 |
NPS-2143(SB 262470A )
NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. |
284035-33-2 |
DC8183 |
Paritaprevir(Veruprevir ABT-450)
Featured
NS3/4A protease inhibitor |
1216941-48-8 |
DC9486 |
Nucleozin
Featured
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. |
341001-38-5 |
DC4174 |
NVP-AEW541
Featured
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM. |
475489-16-8 |
DC4118 |
NVP-BEP800
Featured
NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
847559-80-2 |
DC3133 |
NVP-BGT226 (BGT226)
Featured
NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
1245537-68-1 |
DC7303 |
NVP-TAE684
Featured
NVP-TAE684(TAE684) is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM. |
761439-42-3 |
DC4237 |
NXY-059 (Cerovive)
NXY-059 (Cerovive) is an EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively. |
168021-79-2 |
DC10807 |
O304
Featured
O304 is a novel AMPK activator. |
1261289-04-6 |
DC10134 |
Obicetrapib (AMG-899,TA-8995)
Featured
Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy. |
866399-87-3 |
DC12298 |
Octreotide acetate (SMS 201-995 (acetate))
Featured
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. |
79517-01-4 |
DC6401 |
Odanacatib (MK 0822)
Featured
Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. |
603139-19-1 |
DC8700 |
ODM-201(Darolutamide)
Featured
ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells. |
1297538-32-9 |
DC9583 |
Oglemilast
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma. |
778576-62-8 |
DC11096 |
Olacaftor
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis.. |
1897384-89-2 |
DC4110 |
AZD-2281 (Olaparib)
Featured
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively. |
763113-22-0 |
DCAPI1464 |
Olmesartan
Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction. |
144689-24-7 |
DC9179 |
Olmesartan MedoxoMil
Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive. |
144689-63-4 |
DC10384 |
Olodaterol
Featured
Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM. |
868049-49-4 |
DC9248 |
Olodaterol(BI-1744) hydrochloride
Featured
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. |
869477-96-3 |
DC8390 |
Oltipraz
Featured
Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3. |
64224-21-1 |
DC10299 |
Olumacostat glasaretil
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). |
1261491-89-7 |
DC12281 |
Olutasidenib (FT-2102)
Featured
Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 that could be used in the treatment of acute myeloid leukemia. |
1887014-12-1 |
DC10324 |
Omapatrilat
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively. |
167305-00-2 |
DC7023 |
Ombrabulin
Featured
Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors. |
181816-48-8 |
DC10054 |
Ombrabulin hydrochloride
Featured
Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors. |
253426-24-3 |
DC11044 |
Omidenepag Isopropyl
Featured
Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. |
1187451-19-9 |
DC10043 |
ONO4059 hydrochloride
Featured
ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. |
1439901-97-9 |
DC8358 |
ONO-4059(Tirabrutinib)
Featured
ONO-4059 is a novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase. |
1351636-18-4 |
DC11905 |
Opiranserin
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM). |
1441000-45-8 |
DC2010 |
Oprozomib (ONX-0912)
Featured
Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. |
935888-69-0 |
DC10394 |
Org-26576
Org 26576 is a AMPA receptor positive allosteric modulator. |
100044-96-0 |
DC11203 |
ORIC-101
Featured
ORIC-101 (ORIC101) is a highly potent, selective steroidal glucocorticoid receptor (GR) antagonist (IC50=5.6 nM) with reduced androgen receptor (AR) agonistic activity. |
2222344-98-9 |
DC23149 |
Oseltamivir acid
Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate) is a potent inhibitor of influenza neuraminidase (NA) with Ki of <1 nM for both A and B strains,showed potent activity against COVID-19(SARS-COV-2). |
187227-45-8 |
DCAPI1594 |
Oseltamivir phosphate
Featured
OSELTAMIVIR is an active (orally) inhibitor of the influenze virus neuraminidase and converted to the active acid metabolite in vivo. |
204255-11-8 |
DC1006 |
OSI-027
Featured
OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
936890-98-1 |
DC4105 |
Linsitinib(OSI-906)
Featured
OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively. |
867160-71-2 |
DC7219 |
OSI 930
Featured
OSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. |
728033-96-3 |
DC8248 |
Ostarine(MK-2286)
Featured
Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism. |
841205-47-8 |
DC7220 |
OSU-03012
Featured
OSU-03012(AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
742112-33-0 |
DC9443 |
Otamixaban
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. |
193153-04-7 |
DC7109 |
Otenabant (CP-945598 free base)
Featured
Otenabant (CP945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. |
686344-29-6 |
DC8732 |
OTSSP167
Featured
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
1431697-89-0 |
DC7475 |
OTSSP167 HCl
Featured
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
1431698-10-0 |
DC5885 |
Oxaliplatin
Featured
Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff |
61825-94-3 |
DC8281 |
Ozanimod (RPC1063)
Featured
Ozanimod (RPC1063) is a selective S1P1R modulator |
1306760-87-1 |
DC10399 |
PAC-14028
PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist. |
1005168-10-4 |
DC11113 |
Padsevonil
Padsevonil (UCB-0942, UCB0942) is a potential anti-seizure agent that functions as a pre- and post-synaptic inhibitor.. |
1294000-61-5 |
DC10292 |
Pagoclone
Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders. |
133737-32-3 |
DC8717 |
PAK4-IN-1(KPT9274)
Featured
PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay. |
1643913-93-2 |
DC8469 |
Palbociclib
Featured
Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. |
571190-30-2 |
DC5067 |
Palbociclib (PD0332991 HCl)
Featured
Palbociclib is an oral, small molecule cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, now in Phase 3 clinical development for advanced breast cancer. |
827022-32-2 |
DC7970 |
ACT058362 (Palosuran)
Featured
Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM. |
540769-28-6 |
DC9681 |
Pamapimod(R-1503)
Featured
Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor. |
449811-01-2 |
DC7183 |
Panobinostat(LBH589)
Featured
Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell. |
404950-80-7 |
DC9876 |
Pantoprazole
Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
102625-70-7 |
DC9135 |
Pantoprazole Sodium
Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
138786-67-1 |
DC10255 |
Parecoxib
Parecoxib is a selective COX2 inhibitor. |
198470-84-7 |
DCAPI1503 |
PARECOXIB SODIUM
PARECOXIB SODIUM |
198470-85-8 |
DC6577 |
Paricalcitol
Paricalcitol |
131918-61-1 |
DC10893 |
Parimifasor
Featured
Parimifasor is an immunomodulator, with anti-inflammatory activity. |
1796641-10-5 |
DC9098 |
Paroxetine HCl
Featured
Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). |
110429-35-1 |
DC9776 |
Pazopanib Hydrochloride
Featured
Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
635702-64-6 |
DC2600 |
Pazopanib
Featured
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. |
444731-52-6 |
DC11100 |
PBI-4050 sodium
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1254472-97-3 |
DC11099 |
PBI-4050
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1002101-19-0 |
DC9723 |
PBTZ169
Featured
PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. |
1377239-83-2 |
DC11770 |
PC786
Featured
PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively. |
1902114-15-1 |
DC1106 |
PCI-32765 (Ibrutinib)
Featured
PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM. |
936563-96-1 |
DC10531 |
PCO371
Featured
PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. |
1613373-33-3 |
DC7224 |
PD 123319
Featured
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. |
136676-91-0 |
DC1056 |
PD0325901 (Mirdametinib)
Featured
PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
391210-10-9 |
DC8168 |
Peficitinib(ASP015K,JNJ-54781532)
Featured
Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. |
944118-01-8 |
DC7225 |
Pelitinib (EKB-569; WAY-EKB 569)
Featured
Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. |
257933-82-7 |
DC11360 |
Pemafibrate
Featured
Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. |
848259-27-8 |
DC8149 |
Pemetrexed disodium
Featured
Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
150399-23-8 |
DCAPI1121 |
Peramivir
Peramivir |
229614-55-5 |
DCAPI1010 |
Peramivir Trihydrate
Featured
Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. Peramivir was approved to treat influenza infection in adults. |
1041434-82-5 |
DC7226 |
Perampanel(E2007)
Featured
Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials. |
380917-97-5 |
DC2021 |
Perifosine (KRX-0401)
Featured
Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM. |
157716-52-4 |
DC10529 |
PF 05089771
Featured
PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM. |
1235403-62-9 |
DC8259 |
PF0477736
Featured
PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity |
952021-60-2 |
DC11664 |
PF-00446687 hydrochloride
PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM. |
862282-10-8 |
DC11665 |
PF-00446687
PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM. |
862281-92-3 |
DC3168 |
PF-562271 PHSO3H SALT
Featured
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
939791-38-5 |
DC7059 |
PF-03758309
Featured
PF-03758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. |
898044-15-0 |
DC7081 |
PF-04217903
Featured
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). |
956905-27-4 |
DC8353 |
PF-04418948
Featured
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). |
1078166-57-0 |
DC11367 |
PF-04447943
Featured
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC7027 |
Glasdegib(PF-04449913)
Featured
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor |
1095173-27-5 |
DC7227 |
PF-04620110
Featured
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
1109276-89-2 |
DC3108 |
PF-04971729 (Ertugliflozin)
Featured
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. |
1210344-57-2 |
DC9915 |
PF04995274,PF 04995274
Featured
PF-04995274 is a 5-HT4 receptor partial agonist. It thought to act centrally as a pro-cognitive agent that being developed for the treatment of Alzheimer's disease (AD). |
1331782-27-4 |
DC10050 |
PF05175157
Featured
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. |
1301214-47-0 |
DC11937 |
PF 05180999
Featured
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
1394033-54-5 |
DC11734 |
PF-06263276
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
1421502-62-6 |
DC10631 |
PF-06273340
PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively. |
1402438-74-7 |
DC10500 |
PF-06282999
Featured
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases. |
1435467-37-0 |
DC11466 |
PF-06409577
Featured
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. |
1467057-23-3 |
DC11722 |
PF-06459988
PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. |
1428774-45-1 |
DC7924 |
PF06463922(Lorlatinib)
Featured
PF06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. |
1454846-35-5 |
DC10779 |
PF-06651600
Featured
PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM. |
1792180-81-4 |
DC12488 |
PF-06700841 tosylate
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
2140301-96-6 |
DC10022 |
PF06840003
Featured
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. |
198474-05-4 |
DC2047 |
Crizotinib (PF-2341066)
Featured
PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley. |
877399-52-5 |
DC7201 |
PF-2545920(MP-10)
Featured
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
898562-94-2 |
DC1091 |
PF-299804 (Dacomitinib,PF-00299804)
Featured
PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
1110813-31-4 |
DC7480 |
PF-3274167(cligosiban)
Featured
PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. |
900510-03-4 |
DC3169 |
PF-562271
Featured
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
717907-75-0 |
DC10451 |
PFK158
Featured
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies. |
1462249-75-7 |
DC8335 |
PQR-309(Bimiralisib)
Featured
PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell. |
1225037-39-7 |
DC10728 |
Pibrentasvir(ABT-530)
Featured
Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. |
1353900-92-1 |
DC10047 |
PIM-447 dihydrochloride
Featured
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. |
1820565-69-2 |
DC9815 |
Pimodivir(VX-787)
Featured
Pimodivir(VX-787) is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. |
1629869-44-8 |
DC10012 |
Pirmenol hydrochloride
Featured
Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
61477-94-9 |
DC9465 |
Pitolisant (hydrochloride)
Featured
Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). |
903576-44-3 |
DC7634 |
PKC-412 (Midostaurin)
Featured
PKC-412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. |
120685-11-2 |
DC7238 |
Gedatolisib(PKI-587)
Featured
PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively. |
1197160-78-3 |
DC10016 |
Pleconarilis
Featured
Pleconarilis is a picornavirus replication inhibitor. |
153168-05-9 |
DC5055 |
Plerixafor (AMD3100)
Featured
Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
110078-46-1 |
DC8741 |
Plerixafor octahydrochloride
Featured
Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
155148-31-5 |
DC8158 |
Pexidartinib(PLX3397)
Featured
PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS. |
1029044-16-3 |
DC1071 |
Vemurafenib (PLX4032)
Featured
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
918504-65-1 |
DC6301 |
PLX-4720
Featured
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
918505-84-7 |
DC10786 |
PLX51107
Featured
PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
1627929-55-8 |
DC11373 |
Polmacoxib
Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. |
301692-76-2 |
DC9742 |
Ponesimod
Featured
Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
854107-55-4 |
DCAPI1093 |
Posaconazole
Featured
Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. |
171228-49-2 |
DC11914 |
Poseltinib
Featured
Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM. |
1353552-97-2 |
DC7704 |
Poziotinib
Featured
Poziotinib, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. |
1092364-38-9 |
DC7280 |
Pracinostat(SB939)
Featured
Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I. |
929016-96-6 |
DC9359 |
Pralatrexate
Featured
Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. |
146464-95-1 |
DC8970 |
Pramipexole Base
Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS). |
104632-26-0 |
DC3151 |
Pramipexole dihydrochloride
Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. |
104632-25-9 |
DCAPI1305 |
Pramiracetam
Pramiracetam |
68497-62-1 |
DCAPI1473 |
Pregabalin
Featured
Pregabalin |
148553-50-8 |
DC9902 |
PRIMA-1
Featured
PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. |
5608-24-2 |
DC10070 |
PRIMA-1MET(APR-246)
Featured
PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity. |
5291-32-7 |
DC10641 |
PRN1371
Featured
PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively. |
1802929-43-6 |
DC6903 |
Lapaquistat Acetate (TAK-475)
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
189060-13-7 |
DC4121 |
PSI6130
Featured
PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents. |
817204-33-4 |
DC10464 |
PT2385
Featured
PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. |
1672665-49-4 |
DC7992 |
PX 12
Featured
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h. |
141400-58-0 |
DC7486 |
PX-478 2HCL
Featured
PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells. |
685898-44-6 |
DCAPI1553 |
Pyrimethamine
Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(Pgp) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux |
58-14-0 |
DC7664 |
Quarfloxin (CX-3543)
Featured
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. |
865311-47-3 |
DC5197 |
Quizartinib (AC220)
Featured
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2. |
950769-58-1 |
DC11138 |
Guanabenz acetate
R15A inhibitor. |
23256-50-0 |
DC2068 |
R547
R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively. |
741713-40-6 |
DC9462 |
R-7128(Mericitabine)
Featured
R-7128(Mericitabine) is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. |
940908-79-2 |
DC9841 |
Fostamatinib(R788)
Featured
R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. |
901119-35-5 |
DC1013 |
R788 disodium (Fostamatinib)
Featured
R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM. |
1025687-58-4 |
DC9513 |
Radafaxine (hydrochloride)
Featured
Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulat |
106083-71-0 |
DC5049 |
RAF265 (CHIR-265)
Featured
RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf. |
927880-90-8 |
DC8930 |
Rafoxanide
Rafoxanide is a salicylanilide used as an antiparasitic agent. |
22662-39-1 |
DC9479 |
Raltegravir (potassium salt)
Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection. |
871038-72-1 |
DCAPI1581 |
Raltegravir
Featured
Raltegravir Salt is a potent human immunodeficiency virus (HIV) integrase inhibitor and a novel anti-AIDS drug. |
518048-05-0 |
DC8940 |
Raltitrexed
Featured
Raltitrexed(ZD1694), an inhibitor of thymidylate synthase, is an antimetabolite drug used in cancer chemotherapy. |
112887-68-0 |
DC9162 |
Ranolazine HCl
Featured
Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). |
95635-56-6 |
DC1048 |
Rapamycin (Sirolimus)
Featured
Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. - |
53123-88-9 |
DC8175 |
Rapastinel(GLYX-13)
Featured
Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site. |
117928-94-6 |
DC8190 |
Ravidasvir hydrochloride (PPI-668)
Featured
Ravidasvir(PPI-668) is a NS5A Inhibitor. |
1303533-81-4 |
DC7808 |
Refametinib (BAY86-9766)
Featured
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. |
923032-37-5 |
DC9777 |
Regorafenib monohydrate(BAY 73-4506)
Featured
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
1019206-88-2 |
DC1030 |
Regorafenib (BAY73-4506,Fluoro-Sorafenib)
Featured
Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
755037-03-7 |
DC10441 |
Relebactam
Featured
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. |
1174018-99-5 |
DC10463 |
Repotrectinib(TPX-005)
Featured
Repotrectinib(TPX-005) is a multi-target macrocycle inhibitor of anaplastic lymphoma kinase (ALK), c-ros proto-oncogene 1 receptor tyrosine kinase (ROS1), and neurotrophic tyrosine kinase receptor (TRK) |
1802220-02-5 |
DC7261 |
Resminostat hydrochloride (4SC-201)
Resminostat(RAS2410; 4SC-201) is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. |
1187075-34-8 |
DC4148 |
Retapamulin
Retapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM. |
224452-66-8 |
DC10191 |
RG7800
RG7800 a small molecule SMN2 splicing modifier to enter human clinical trials to treat spinal muscular atrophy. |
1449598-06-4 |
DC8185 |
Verosudil(AR-12286)
Rho-kinase (ROCK) inhibitor |
1414854-42-4 |
DCAPI1165 |
Ribavirin (Copegus)
Featured
Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza. |
36791-04-5 |
DCAPI1325 |
Rifabutin (Mycobutin)
Rifabutin (Mycobutin) |
72559-06-9 |
DC7265 |
Rigosertib
Featured
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3. |
1225497-78-8 |
DC7266 |
Rilpivirine(R 278474, TMC 278)
Featured
Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). |
500287-72-9 |
DC7268 |
Risperidone(R 64 766)
Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM). |
106266-06-2 |
DC9475 |
Ritonavir
Featured
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS,showed potent activity against COVID-19(SARS-COV-2) . |
155213-67-5 |
DC5108 |
BAY 59-7939 (Rivaroxaban)
Featured
Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
366789-02-8 |
DCAPI1435 |
Rivastigmine tartrate
Rivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and Parkinson's disease. |
129101-54-8 |
DC5146 |
RN486
Featured
RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor. |
1242156-23-5 |
DC9454 |
Ro 28-1675
Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM. |
300353-13-3 |
DC9666 |
Ro 46-2005
Featured
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. |
150725-87-4 |
DC7933 |
Ro 48-8071 fumarate
Featured
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. |
189197-69-1 |
DC8215 |
RO4929097
Featured
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. |
847925-91-1 |