Cat. No. | Product name | CAS No. |
DC21633 |
SEL120-34A
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively. |
1609522-33-9 |
DC21634 |
SEL120-34A hydrochloride
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively. |
1609452-30-3 |
DC21661 |
SEL-201
Featured
SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively. |
2095704-43-9 |
DC21635 |
SEL24-B489
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
1616359-00-2 |
DC21636 |
SEL24-B489 hydrochloride
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
|
DC7536 |
YM-90K hydrochloride
Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM For AMPA, kainate and NMDA receptors respectively). Neuroprotective. |
154164-30-4 |
DC26028 |
RO-3
Featured
RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7)[1]. |
1026582-88-6 |
DC9864 |
Azidothymidine (AZT)
Selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. |
30516-87-1 |
DC10193 |
Seletalisib
Featured
Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM. |
1362850-20-1 |
DC21948 |
Selgantolimod
Selgantolimod is a novel toll-like receptor TLR8 modulator for the treatment of HIV infection.. |
2004677-13-6 |
DC11912 |
Seliforant
Seliforant (SENS-111, SENS111) is a novel potent, selective histamine H4 receptor antagonist.. |
1164115-89-2 |
DC20770 |
Selurampanel
Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM. |
912574-69-7 |
DC7496 |
Semagacestat
Featured
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. |
425386-60-3 |
DC20914 |
Semapimod
Semapimod (CNI 1493. |
352513-83-8 |
DC20915 |
Semapimod hydrochloride
Semapimod (CNI 1493. |
164301-51-3 |
DC20544 |
SEMBL
Featured
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65. |
1443448-82-5 |
DC21578 |
Sembragiline
Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A. |
676479-06-4 |
DC23735 |
SEN 1269
SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM. |
956128-01-1 |
DC10628 |
Senexin A
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. |
1366002-50-7 |
DC20545 |
Senktide
Senktide is a potent, selective agonist of neuromedin K3 (NK3) receptor (EC50 =0.5-3 nM), less potently agonizes the NK1 receptor (EC50=35 µM) and is without effect on the NK2 receptor.. |
106128-89-6 |
DC21409 |
Sephin 1
Featured
Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex. |
951441-04-6 |
DC21637 |
Sepin-1
Featured
Sepin-1 is a small molecule, noncompetitive separase inhibitor with IC50 of 14.8 uM. |
163126-81-6 |