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Cat. No. Product name CAS No.
DC9857 RG-13022 Featured

RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 µM in HT-22 cells.

136831-48-6
DC10367 RG14620 Featured

RG14620 is an epidermal growth factor receptor (EGFR) inhibitor, with IC50 values of 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis.

136831-49-7
DC7795 RG2833 (RGFP109) Featured

RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

1215493-56-3
DC7721 RG7090(Basimglurant) Featured

RG7090(CTEP Derivative,Basimglurant, RO4917523) is a negative modulator of metabotropic glutamate receptor subtype 5 (mGluR5; GRM5).

802906-73-6
DC8865 RG-7112 Featured

RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.

939981-39-2
DC7821 Idasanutlin (RG-7388) Featured

RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53.

1229705-06-9
DC20005 RG7834 (RO 7020322) Featured

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.

2072057-17-9
DC7768 RGB286638 Featured

RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

784210-88-4
DC7263 RGFP 966 Featured

RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM.

1357389-11-7
DC10719 RGX-104 Featured

RGX-104 is an orally bioavailable agonist of the nuclear receptor liver X receptor beta (LXRbeta; NR1H2; LXR-b), with potential immunomodulating and antineoplastic activities.

610318-03-1
DC21565 RH01687 Featured

RH01687 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.

302901-13-9
DC23734 Rheb inhibitor NR1 Featured

Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK.

2216763-38-9
DC23192 Rhosin hydrochloride Featured

Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG.

1281870-42-5
DC9881 RHPS4 Featured

RHPS4 is a potent inhibitor of Telomerase at submicromolar.

390362-78-4
DC7264 RI-1 Featured

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

415713-60-9
DC8226 RI-2 Featured

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

1417162-36-7
DCAPI1165 Ribavirin (Copegus) Featured

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza.

36791-04-5
DC24015 Ribocil Featured

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.

1381289-58-2
DC7265 Rigosertib Featured

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM; shows 30-fold greater selectivity against PLK2 and no activity to PLK3.

1225497-78-8
DC24085 Rigosertib sodium Featured

Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.

592542-60-4
DC7266 Rilpivirine(R 278474, TMC 278) Featured

Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

500287-72-9
DC8985 Riluzole Featured

Riluzole is a glutamate antagonist used as an anticonvulsant and to prolong the survival of patients with amyotrophic lateral sclerosis.

1744-22-5
DC12800 BMS-927711(Rimegepant) Featured

Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.

1289023-67-1
DC9383 Rimonabant (Hydrochloride) Featured

Rimonabant Hcl(SR141716A) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM.

158681-13-1
DC8876 Rimonabant(SR141716) Featured

Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM.

168273-06-1
DC7267 Riociguat (BAY 63-2521) Featured

Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase (sGC).

625115-55-1
DC10389 RIPA-56 Featured

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.

1956370-21-0
DC21563 Risdiplam Featured

Risdiplam (RG7916, RG-7916, RO7034067) is a highly potent, selective, orally active SMN2 splicing modifier for treatment of spinal muscular atrophy (SMA).

1825352-65-5
DC1064 RITA (NSC652287) Featured

RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells.

213261-59-7
DC9475 Ritonavir Featured

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS,showed potent activity against COVID-19(SARS-COV-2) .

155213-67-5
DC5108 BAY 59-7939 (Rivaroxaban) Featured

Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.

366789-02-8
DC12372 RK-24466 Featured

RK-24466 (KIN 001-51) is a potent and selective Lck inhibitor; inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.

213743-31-8
DC12436 RK-287107 Featured

RK-287107 (RK287107) is a novel potent, tankyrase-specific inhibitor with IC50 of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively, shows no activity against PARP-1.

2171386-10-8
DC9761 RK-33 Featured

RK-33 is a novel DDX3 inhibitor for lung cancer therapy.

1070773-09-9
DC8831 RKI-1313 Featured

RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer

1342276-76-9
DC7269 RKI-1447 Featured

RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.

1342278-01-6
DC12051 RMC-4550 Featured

RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM.

2172651-73-7
DC7636 RN-1 Hydrochloride Featured

RN-1 is an inhibitor of lysine specific demethylase 1 (LSD1); exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively.

1781835-13-9
DC11325 RN-1734 Featured

RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4α-phorbol 12,13-didecanoate with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively.

946387-07-1
DC10450 RN-18 Featured

RN-18 is a selective inhibitor of virion infectivity factor (Vif) APOBEC interactions and HIV-1 replication.

431980-38-0
DC5146 RN486 Featured

RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor.

1242156-23-5
DC9852 Ro 25-6981 maleate Featured

Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.

1312991-76-6
DC22215 RO 27-3225 Featured

RO 27-3225 (RO27-3225, RO 273225) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R.

DC7270 Ro 31-8220 mesylate Featured

Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.

138489-18-6
DC9686 Ro 41-1049 hydrochloride Featured

Ro 41-1049 hydrochloride is a selective, reversible inhibitor of MAO-A.

127500-84-9
DC9666 Ro 46-2005 Featured

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

150725-87-4
DC7933 Ro 48-8071 fumarate Featured

Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.

189197-69-1
DC22213 Ro 60-0175 Featured

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.

169675-08-5
DC7656 Ro 61-8048 Featured

Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase inhibitor (Ki = 4.8 nM, IC50 = 37 nM).

199666-03-0
DC9759 RO0921 Featured

RO0921 is a novel, potent SYK inhibitor.

1446790-62-0
DC7271 Ro3280 Featured

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

1062243-51-9
DC3116 RO-3306 Featured

Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.

872573-93-8
DC8215 RO4929097 Featured

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.

847925-91-1
DC8528 RO495 Featured

RO495 is a very potent TYK2 inhibitor with a IC50 of 1.5nM on TYK2 as tested in cell-based pharmacological assays

1258296-60-4
DC10583 RO 5028442 Featured

RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

920022-47-5
DC8467 RO8994 Featured

RO8994 is a potent and selective spiroindolinone MDM2 inhibitor for cancer therapy.

1309684-94-3
DC20537 Robenacoxib Featured

Robenacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the relief of pain and inflammation in cats and dogs, a Cyclooxygenase(COX)-1 and COX-2 inhibitor..

220991-32-2
DC10097 ROC-325 Featured

ROC-325 is a Novel Small Molecule Inhibitor of Autophagy with Promising Anti-Leukemic Activity.

1859141-26-6
DC7048 Ricolinostat (ACY-1215) Featured

Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM; >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.

1316214-52-4
DC4146 Roflumilast Featured

Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.

162401-32-3
DC10759 Roflumilast N-oxide Featured

Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Roflumilast N-oxide is the active metabolite of roflumilast.

292135-78-5
DC20745 Rogaratinib Featured

Rogaratinib (BAY 1163877) is a potent, selective, orally available pan-FGFR with IC50 of 15, <1, 19 and 33 nM for FGFR1, 2, 3 and 4, respectively.

1443530-05-9
DCAPI1434 Romidepsin(FK-228) Featured

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.

128517-07-7
DCAPI1439 Ropivacaine HCL Featured

Ropivacaine Hydrochloride Monohydrate is used as a local anesthetic.

132112-35-7
DC4124 ROSCOVITINE(Seliciclib) Featured

Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

186692-46-6
DC22834 Roseoflavin Featured

Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.

51093-55-1
DCAPI1480 rosiglitazone maleate Featured

Rosiglitazone maleate is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits T

155141-29-0
DC7490 Rostafuroxin Featured

Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.

156722-18-8
DC23834 Rottlerin Featured

Rottlerin (Mallotoxin.

82-08-6
DC21585 Brilaroxazine Featured

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs.

1239729-06-6
DC11480 Rp-8-bromo-Cyclic AMPS Featured

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.

925456-59-3
DC7986 RPI-1 Featured

RPI-1 is a cell-permeable ATP-competitive tyrosine kinase inhibitor

269730-03-2
DC8306 RQ-00203078 Featured

RQ-00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).

1254205-52-1
DC11467 RR6 Featured

RR6 is a selective, reversible, and competitive vanin inhibitor.

1351758-37-6
DC10036 RRx-001 Featured

RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia.

925206-65-1
DC9251 RS-102895 hydrochloride Featured

RS 102895 hydrochloride is a chemokine receptor CCR2 antagonist.

1173022-16-6
DC9388 RS 504393 Featured

RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).

300816-15-3
DC8839 RS-1 Featured

RS-1 is a stimulator of the human homologous recombination protein RAD51,enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

312756-74-4
DC8334 RS-127445 Featured

RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.

199864-87-4
DC9746 RSL3 Featured

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.

1219810-16-8
DC10006 RSV-604 Featured

RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.

676128-63-5
DC8198 RTA-408(Omaveloxolone) Featured

RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB.

1474034-05-3
DC11039 RTI-13951-33 Featured

RTI-13951-33 is a potent, selective, brain-penetrant agonist of the orphan receptor GPR88 with EC50 of 25 nM in in vitro cAMP functional assay.

2244884-08-8
DC12483 RTS-V5 Featured

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3.

2285346-31-6
DC7985 RU 24969 hemisuccinate Featured

RU 24969 hemisuccinate is a potent SR-1A/SR-1B and moderate SR-2C agonist that may also release serotonin.

107008-28-6
DC22732 RU1968 Featured

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.

171336-24-6
DC11690 RU-302 Featured

RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.

1182129-77-6
DC22305 RU-521 Featured

RU-521 (RU.521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.

2262452-06-0
DC4163 RU58841 Featured

RU58841 is a nonsteroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) comparable to hydroxyflutamide.

154992-24-2
DC23090 Rubusoside Featured

Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.Rubusoside can improve the survival rate of palmitic acid- induced INS- 1 cells and inhibit the occurrence of apoptosis.

64849-39-4
DC5151 Rucaparib phosphate (AG-14699, PF-01367338) Featured

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM with binding affinity to nine PARP domains. Phase 1/2.

459868-92-9
DC8464 Rucaparib(AG-014447) Featured

Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM.

283173-50-2
DC7272 Rufinamide Featured

Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).

106308-44-5
DC21947 Runcaciguat Featured

Runcaciguat is a potent soluble guanylyl cyclase (sGC) stimulator/activator..

1402936-61-1
DCAPI1593 Rupatadine Featured

Rupatadine is a dual histamine H1 and PAF antagonist

182349-12-8
DC20647 Rupintrivir Featured

Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.

223537-30-2
DC4230 Ruxolitinib (INCB018424) Featured

Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM).

941678-49-5
DC8309 Ruxolitinib Phosphate Featured

Ruxolitinib Phosphate is a potent and selective Janus kinase (JAK1, IC50 = 5.9 nM and JAK2, IC50 = 5.7 nM) inhibitor.

1092939-17-7
DC8320 RVX-208 Featured

RVX-208(RVX 000222) is a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; is a BET bromodomain antagonist.

1044870-39-4
DC7762 RX-3117 Featured

RX-3117 is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity.

865838-26-2
DC10479 RX518(CK-101:EGFR-IN-3) Featured

RX518(CK-101) is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations.

1660963-42-7
DC21684 Ryuvidine Featured

Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).

265312-55-8
DC10622 S38093 Featured

S 38093 is a brain-penetrant antagonist of H3 receptor, with Ki of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.

862896-30-8
DC11271 S38093 HCl Featured

S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.

1222097-72-4
DC8057 S-Etomxir Featured

S isomer of R-Etomoxir

828934-43-6
DC7882 S0859 Featured

S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).

1019331-10-2
DC10395 S107 Featured

S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

927871-76-9
DC11030 S119-8 Featured

S119-8 is a novel broad spectrum inhibitor of influenza virus replication (IC50=1.43 nM) by targeting the viral Nucleoprotein (NP), with no detectable cytotoxicity (CC50>50 uM).

443639-96-1
DC12546 S18-000003 Featured

S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM).

2068119-11-7
DC23578 S-18986 Featured

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

175340-20-2
DC7274 S1RA Featured

S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).

878141-96-9
DC9264 S1RA hydrochloride Featured

S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).

1265917-14-3
DC11455 Bz-Ile-Glu-Gly-Arg-pNA acetate salt Featured

S-2222 is a chromogenic substrate for Factor Xa.

59068-47-2
DC9807 S-2238(Thrombin Substrate) Featured

S-2238 is specific to thrombin, is a short peptide covalently bound to pNA (4-nitroaniline).

115388-96-0
DC10811 S23 Featured

S23 is a novel Selective Androgen Receptor Modulator(SARM)

1010396-29-8
DC12622 S29434 Featured

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.

874484-20-5
DC1033 S3I-201 (NSC-74859) Featured

S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM.

501919-59-1
DC11265 S49076 (hydrochloride) Featured

S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.

1265966-31-1
DC10071 S49076 Featured

S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.

1265965-22-7
DC12163 S55746 (BLC201) Featured

S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity[1].

1448584-12-0
DC10137 S63845 Featured

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.

1799633-27-4
DC8529 S6K-18 Featured

S6K-18 is a highly selective inhibitor of S6K1, with an IC50 of 52nM.

1265789-88-5
DC8506 S-99 Featured

S-99 inhibits LPS-induced TNFa release assay in vivo

1124381-69-6
DC8227 SA4503 2HCl Featured

SA4503 is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM); 100-fold less affinity for the sigma 2 receptor.

165377-44-6
DC8444 Sabutoclax Featured

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

1228108-65-3
DC8099 Saclofen Featured

Saclofen is a selective GABAB antagonist.

125464-42-8
DCAPI1520 S-adenosyl-L-methionine(Ademetionine) Featured

Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. Ademetionine is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA. Pharmaceutical preparations of some stable salts of SAMe are available for parenteral and oral use in humans, and have been shown to increase plasma and cerebrospinal fluid SAMe concentrations.

29908-03-0
DC26016 Safinamide mesylate Featured

Safinamide mesylate is a third-generation reversible MAO-B inhibitor, which also blocks sodium voltage-sensitive channels and modulates stimulated release of glutamate.

202825-46-5
DC8738 Sal003 Featured

Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.

1164470-53-4
DC11346 Salbutamol (hydrochloride) Featured

Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).

50293-90-8
DC10002 Salermide Featured

Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.

1105698-15-4
DC7275 Salidroside Featured

Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.

10338-51-9
DC8420 Salirasib Featured

Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.

162520-00-5
DC11014 SALL4 peptide FFW Featured

SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM.

DC8436 Salmeterol Xinafoate Featured

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

94749-08-3
DC8610 Salmeterol Featured

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

89365-50-4
DC9010 Sasapyrine Featured

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).

552-94-3
DCAPI1177 Salubrinal Featured

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.

405060-95-9
DC5998 Salvianolic acid B Featured

Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease.

121521-90-2
DC8327 SANT-1 Featured

SANT-1 is a membrane permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway by direct binding to Smo.

304909-07-7
DC23030 Santalol Featured

Santalol has good antibacterial, anti-oxidation and anti-tumor activities.

11031-45-1
DC10444 Sapacitabine (CYC682) Featured

Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity.

151823-14-2
DC7078 AZD-8931(Sapitinib) Featured

Sapitinib(AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM respectively.

848942-61-0
DC8627 Saquinavir Featured

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

127779-20-8
DC8628 Saquinavir Mesylate Featured

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

149845-06-7
DC8224 Lifitegrast(SAR 1118) Featured

SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye.

1025967-78-5
DC9792 SAR020106 Featured

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme.

1184843-57-9
DC10925 SAR-100842 Featured

SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.

1195941-38-8
DC7672 SAR125844 Featured

SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity.

1116743-46-4
DC8530 SAR131675 Featured

SAR131675 is a potent and selective VEGFR-3 inhibitor.

1433953-83-3
DC10823 SAR-20347 Featured

SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively.

1450881-55-6
DC10499 SAR348830 Featured

SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).

1462949-64-9
DC22521 SAR405 Featured

SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM.

1523406-39-4
DC9854 SAR407899 Featured

SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.

923359-38-0
DC7276 Saracatinib (AZD0530) Featured

Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q).

379231-04-6
DC12276 Saridegib (IPI-926; Patidegib) Featured

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

1037210-93-7
DC12047 Sarolaner(PF-6450567) Featured

Sarolaner is a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs

1398609-39-6
DC9313 Sarpogrelate (hydrochloride) Featured

Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.

135159-51-2
DC9215 Sarsasapogenin(Spirostan-3-ol) Featured

Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.

82597-74-8
DC9692 Volitinib(Savolitinib) Featured

Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity.

1313725-88-0
DCAPI1568 Saxagliptin Hydrochloride Featured

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.

709031-78-7
DC8875 Saxagliptin Featured

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.

361442-04-8
DC2097 SB202190 Featured

SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway.

152121-30-7
DC4227 SB216763 Featured

SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).

280744-09-4
DC7245 SB 222200 Featured

SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.

174635-69-9
DC7807 SB 239063 Featured

SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.

193551-21-2
DC9459 SB 415286 Featured

SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.

264218-23-7
DC22223 SB02024 Featured

SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro.

2126737-28-6
DC1004 SB-203580 Featured

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.

152121-47-6
DC9924 SB218078 Featured

SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively).

135897-06-2
DC7913 SB225002 Featured

SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

182498-32-4
DC4102 SB-269970,SB 269970 Featured

SB269970 is a potent and selective 5-HT7 receptor antagonist.

201038-74-6
DC7495 SB-334867 HCl Featured

SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.

249889-64-3
DC8419 SB-334867 Featured

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

792173-99-0
DC9735 SB-366791 Featured

SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research.

472981-92-3
DC8483 SB-399885 HCl Featured

Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).

402713-80-8
DC7670 SB-3CT Featured

SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

292605-14-2
DC7277 SB-408124 Featured

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor.

288150-92-5
DC5189 SB-431542 Featured

SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

301836-41-9
DC7278 SB-505124 Featured

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.

694433-59-5
DC6312 SB525334 Featured

SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

356559-20-1
DC7279 SB-590885 Featured

SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.

405554-55-4
DC22415 SB-612111 Featured

SB-612111 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) antagonist with Ki of 0.33 nM.

371980-98-2
DC9573 SB-674042 Featured

SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.

483313-22-0
DC9635 SB-705498 Featured

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

501951-42-4
DC8354 Intepirdine (SB-742457, RVT-101) Featured

SB-742457(RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.

607742-69-8
DC5137 SB 743921 Featured

SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

940929-33-9
DC10470 SB756050 Featured

SB-756050 is a Farnesoid X receptor (FXR) (NR1H4) agonist.

447410-57-3
DC10729 SB9200(Inarigivir soproxil) Featured

SB9200(Inarigivir soproxil) is a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants.

942123-43-5
DC10148 SBC-110736 Featured

SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), lowering cholesterol levels in mice.

1629166-02-4
DC8349 SBC-115076 Featured

SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases.

489415-96-5
DC7965 SBE 13 hydrochloride Featured

SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.

1052532-15-6
DC8316 SBI-0206965 Featured

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor.

1884220-36-3
DC10511 SBI-0640756 Featured

SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

1821280-29-8
DC24210 SBI-115 Featured

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

882366-16-7
DC21624 SBI-425 Featured

SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM, shows high selectivity over other alkaline phosphatases including IAP and PLAP.

1451272-71-1
DC21625 SBI-477 Featured

SBI-477 is a chemical probe that coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes with EC50 of 100 nM and 1 uM, respectively.

781628-99-7
DC11283 SBI993 Featured

SBI-993 is an analog of SBI-477 that shows improved potency and suitable pharmacokinetic properties for in vivo bioavailability

2073059-82-0
DC7599 SC1(Pluripotin) Featured

SC1(Pluripotin) is a sustainer of mES self-renewal and ERK 1 inhibitor

839707-37-8
DC5030 SC144 Featured

SC144 is an orally active small-molecule gp130 inhibitor.

895158-95-9
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