Cat. No. | Product name | CAS No. |
DC12636 |
Apararenone
Featured
Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.. |
945966-46-1 |
DC4101 |
Apatinib Mesylate
Featured
Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
1218779-75-9 |
DC8465 |
Apatinib (free base)
Featured
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
811803-05-1 |
DC20310 |
Apcin
Featured
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
300815-04-7 |
DC8804 |
APD597(JNJ-38431055)
Featured
APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. |
897732-93-3 |
DC21448 |
Apicidin
Featured
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
183506-66-3 |
DC8275 |
Apilimod
Featured
Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
541550-19-0 |
DC8276 |
Apilimod mesylate
Featured
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
870087-36-8 |
DC5114 |
Apixaban (BMS 562247-01)
Featured
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
503612-47-3 |
DC23522 |
Aplaviroc HCl
Featured
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
461023-63-2 |
DC6901 |
Daporinad(FK866,APO866)
Featured
APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. |
658084-64-1 |
DC23901 |
R-(-)-Apomorphine
Featured
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
41372-20-7 |
DC2066 |
Apoptosis Activator 2
Featured
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. |
79183-19-0 |
DC10122 |
Apoptozole
Featured
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
1054543-47-3 |
DC7063 |
Apremilast
Featured
Apremilast(CC10004) is a novel small molecule inhibitor of PDE4 with an IC50 value of 74 nM. |
608141-41-9 |
DC11513 |
Aprocitentan (ACT-132577)
Featured
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting. |
1103522-45-7 |
DC10048 |
APS-2-79
Featured
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
2002381-25-9 |
DC9808 |
APS-2-79 hydrochloride
Featured
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
2002381-31-7 |
DC9809 |
APS-3-77 HCl
Featured
APS-3-77 is the negative binder of KSR2. |
|
DC20672 |
APX001A
Featured
APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
936339-60-5 |
DC11809 |
APX-115
Featured
APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
1270084-92-8 |
DC7922 |
APY0201
Featured
APY0201 is a potent, highly selective PIKfyve kinase inhibitor. |
1232221-74-7 |