| DC21372 |
NCGC00185684 |
NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor. |
|
| DC10476 |
NCGC00244536
Featured
|
NCGC00244536 is a potent KDM4A inhibitor with an IC50 of 10 nM. |
|
| DC8857 |
NCT-501 |
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. |
|
| DC23741 |
NCT-502 |
NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells. |
|
| DC10486 |
NCT-503
Featured
|
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM. |
|
| DC12128 |
NCT-505
Featured
|
NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM). |
|
| DC20004 |
NCT-506
Featured
|
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM. |
|
| DC21387 |
NCX-4016 |
NCX-4016 (Nitroaspirin. |
|
| DC10173 |
Firsocostat(ND-630,GS-0976)
Featured
|
ND-630 is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. |
|
| DC9810 |
ND-646
Featured
|
ND-646(ND646) is a small-molecule allosteric inhibitor of acetyl-CoA carboxylase (ACC). |
|
| DC23681 |
ND-654 (ND654) |
ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively. |
|
| DC10302 |
N-deacetylated BMS-202 |
N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-l/PD-Ll interaction, mainly used for cancer treatment. |
|
| DC9347 |
N-desmethyl Enzalutamide
Featured
|
N-desmethyl Enzalutamide(N-desmethyl MDV3100) is a major metabolite of Enzalutamide, Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
|
|
| DC10438 |
N-Desmethylclozapine
Featured
|
N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor. |
|
| DC21374 |
NDT 9513727 |
NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay. |
|
| DC12348 |
NE 10790 (3-PEHPC)
Featured
|
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. |
|
| DC10455 |
NE-100
Featured
|
NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, |
|
| DC12511 |
Nebicapone |
Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM. |
|
| DCAPI1592 |
Nebivolol hydrochloride |
Nebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist |
|
| DC10551 |
Necrostatin 2 racemate
Featured
|
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. |
|
| DC2084 |
Necrostatin-1
Featured
|
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
|
| DC9817 |
Necrosulfonamide (NSA)
Featured
|
Necrosulfonamide (NSA) is a very specific and potent necrosis inhibitor with an IC50 less than 0.2 uM. |
|
| DC23292 |
Necrox-5 methanesulfonate
Featured
|
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter. |
|
| DC21375 |
NecroX-2
Featured
|
NecroX-2 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI. |
|
| DCAPI1393 |
Nedaplatin (Aqupla)
Featured
|
Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL. |
|
| DC20473 |
NEDD8 inhibitor M22
Featured
|
NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor. |
|
| DC7472 |
Nedocromil |
Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma. |
|
| DC9569 |
Nefazodone (hydrochloride)
Featured
|
Nefazodone hydrochloride is an antidepressant drug. |
|
| DC23246 |
Nef-IN-B9 |
Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM. |
|
| DCAPI1574 |
Nefiracetam |
Nefiracetam is a nootropic of the racetam family. Nefiracetam is cognitive enhancer with an IC50 of approximately 150–200 μM for Ro 5-4864. This compound activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Nefiracetam di |
|
