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Cat. No. Product name CAS No.
DC12029 BAY-299 Featured

BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC50 = 6 nM).

2080306-23-4
DC10978 BAY-3827 Featured

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK as tool compound to evaluate the therapeutic potential of AMPK inhibition in MYC-dependent tumors; strongly inhibits Acetyl-CoA carboxylase (ACC) phosphorylation in COLO 320DM and IMR-32 cells, but fails to inhibit the proliferation of cells with dysregulated c-MYC or N-MYC.

2377576-35-5
DC26010 BAY-545 Featured

BAY-545 is a novel, potent and selective antagonist of A2B adenosine receptor with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2Badenosine receptor in cells, respectively.

1699717-32-2
DC12653 BAY-598 Featured

BAY-598 is a selective inhibitor of SMYD2.

1906919-67-2
DC11218 BAY-8002 Featured

BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM).

724440-27-1
DC11505 BAY-850 Featured

BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.

2099142-76-2
DC10107 BAY-876 Featured

BAY-876 is the first highly selective GLUT1 inhibitor with IC50 of 0.002 uM. show good metabolic stability in vitro and high oral bioavailability in vivo.

1799753-84-6
DC10057 Bayer-18 Featured

Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays.

1251752-12-1
DC7372 Bazedoxifene-Acetate Featured

Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues.

198481-33-3
DC8922 Bazedoxifene Featured

Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment.

198481-32-2
DC20754 BC-1215 Featured

BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.

1507370-20-8
DC10885 BCI-121 Featured

BCI-121 is a SMYD3 inhibitor that impairs the proliferation of cancer cell.

432529-82-3
DC9826 BCTC Featured

BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.

393514-24-4
DC8313 BD1047.2HBr Featured

BD 1047 dihydrobromide is a selective antagonist of σ receptors.

138356-21-5
DC23499 BD-1047 Featured

BD-1047 is a potent, selecitve Sigma 1 receptor (σ1) antagonist with Ki of 0.93 nM.

138356-20-4
DC10280 BD1063 dhydrochloride Featured

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

206996-13-6
DC9709 BDA-366 Featured

BDA-366 is a Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.

1909226-00-1
DC21101 BDCRB Featured

BDCRB (GW 275175) is a potent and selective inhibitor of human CMV replication by blocking the processing and maturation of viral DNA..

142356-43-2
DC10860 BDP5290 Featured

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

1817698-21-7
DC20765 BDT001 Featured

BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.

823837-22-5
DC9718 BEBT-908(CUDC-908) Featured

BEBT-908(CUDC-908)is a novel PI3K/HDAC inhibitor.

1235449-52-1
DC9964 BEC hydrochloride Featured

BEC is a boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginase I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).

222638-67-7
DC8809 Bedaquiline fumarate Featured

Bedaquiline fumarate(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.

845533-86-0
DC21007 Befiradol Featured

Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.

208110-64-9
DC7082 Belinostat (PXD101) Featured

Belinostat (PXD101) is a novel pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors.

414864-00-9
DC10448 Belizatinib(TSR-011) Featured

Belizatinib(TSR-011) is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity.

1357920-84-3
DC11470 Belotecan hydrochloride(CKD-602) Featured

Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative.

213819-48-8
DC12278 Belvarafenib Featured

Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

1446113-23-0
DC6908 Bendamustine HCL (SDX-105, Cytostasane) Featured

Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

3543-75-7
DC10701 Benzamide (NSC 404988) Featured

Benzamide (NSC 404988) is a bioactive compound.

7461-38-3
DC26053 Benzamil (hydrochloride) Featured

Benzamil hydrochloride is a specific and potent sodium channel (ENaC) blocker.

161804-20-2
DC8895 benzbromaron Featured

Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout.

3562-84-3
DC20028 Benznidazole (Synonyms: Benznidazol; Ro 07-1051; Ro 71051) Featured

Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease.

22994-85-0
DCAPI1500 Bepotastine Besilate Featured

Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist.

190786-44-8
DC8898 Bepotastine Featured

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor.

125602-71-3
DC11403 Bepridil hydrochloride Featured

Bepridil hydrochloride is a calcium channel blocker, with antianginal activity.

68099-86-5
DC4143 Besifloxacin HCl Featured

Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic.

405165-61-9
DC21382 EIDD-1931(NHC) Featured

EIDD-1931 (β-d-N4-Hydroxycytidine, NHC) inhibits both murine hepatitis virus (MHV) (EC50 of 0.17 μM) and Middle East respiratory syndrome CoV (MERS-CoV) (EC50 of 0.56 μM) with minimal cytotoxicity. It also inhibits SARS-CoV-2 and multiple 2 endemic, epide

3258-02-4
DC10655 3-Guanidinopropionic acid Featured

Beta-guanidinopropionic acid is a novel creatine kinase inhibitor.

353-09-3
DC8830 Betahistine Featured

Betahistine is a strong affinity histamine H3 receptor antagonist and weak affinity agonist of histamine H1 receptors.

5638-76-6
DC7905 beta-Lapachone (ARQ-501, CO-501) Featured

Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.

4707-32-8
DC11105 Umibecestat Featured

beta-secretase inhibitor.

1387560-01-1
DC11566 BETd-260 Featured

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

2093388-62-4
DC7373 Betrixaban Featured

Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).

330942-05-7
DC11483 Betrixaban maleate Featured

Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).

936539-80-9
DC9832 Betulinic acid Featured

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M.

472-15-1
DC23068 Liquidambaric acid Featured

Betulonic acid has anti-cancer , anti-HIV,hepatoprotective and anti-inflammatory activities, it has antiviral activity against herpes simplex virus, it also suppresses ECHO 6 virus reproduction.

4481-62-3
DC9643 Bevirimat(PA-457) Featured

Bevirimat(YK FH312; FH11327; MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.

174022-42-5
DC8186 Bexagliflozin3 Featured

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.

1118567-05-7
DC8786 NVP-BEZ235 Tosylate Featured

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

1028385-32-1
DC3136 NVP-BEZ235 Featured

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

915019-65-7
DC12131 BF-227(E/Z) Featured

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

845647-80-5
DC9956 BFH772 Featured

BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM.

890128-81-1
DC8310 BG-45 Featured

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).

926259-99-6
DC10059 BGG463 Featured

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

890129-26-7
DC5194 NVP-BGJ398(Infigratinib) Featured

BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.

872511-34-7
DC8571 BGP-15 Featured

BGP-15 is a PARP inhibitor and insulin sensitizer.

66611-37-8
DC9695 BH3I-1 Featured

BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL. BH3I-1 is an inhibitor of Bcl-xL.

300817-68-9
DC21546 BI-1467335 HCl Featured

BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.

1478364-68-9
DC22021 BI 167107 Featured

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

1202235-68-4
DC11389 BI 409306 Featured

BI 409306 is an inhibitor of phosphodisterase 9A(PDE9A).

1189767-28-9
DC20781 BI 671800 Featured

BI 671800 is a potent, oral prostaglandin D2 receptor (CRTH2) antagonist for treatment of asthma..

1093108-50-9
DC23560 BI01383298 Featured

BI01383298 (BI-01383298) is a potent, specific sodium-citrate co-transporter SLC13A5 (NaCT, INDY), highly selective over other family members and other transporters..

2227549-00-8
DC12406 BI-0314 Featured

BI-0314 (BI0314) is an allosteric activator of protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) with potency of 56% at 500 uM, displays no activity against hPTP1B and hTCPTP.

2244560-46-9
DC20775 BI-1347 Featured

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC with IC50 of 1 nM.

2163056-91-3
DC7083 Bi 2536 Featured

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM).

755038-02-9
DC20779 BI-3802 Featured

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

2166387-65-9
DC23310 BI-3812 Featured

BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.

2166387-64-8
DC22310 BI-4464 Featured

BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM..

1227948-02-8
DC11960 BI605906 Featured

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.

960293-88-3
DC7107 BI-78D3 Featured

BI-78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.

883065-90-5
DC8401 BI-847325 Featured

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

1207293-36-4
DC9888 BI-9564 Featured

BI-9564 is a selective, and cell-permeable BRD9 BD inhibitor, with Kd of 5.9 nM for BRD9, and IC50 of > 100 μM for BET family.

1883429-22-8
DC10404 BIA 10-2474 Featured

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.

1233855-46-3
DC20788 BIBO-3304 Featured

BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.

191868-14-1
DC7085 BIBR-1532 Featured

BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.

321674-73-1
DCAPI1112 BIBR 953(Dabigatran) Featured

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate.

211914-51-1
DC1010 BIBR-1048 (Dabigatran etexilate) Featured

BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.

211915-06-9
DC9670 BIBS39 Featured

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.

133085-33-3
DC1024 Afatinib (BIBW2992) Featured

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

439081-18-2
DC10890 Bictegravir Featured

Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

1611493-60-7
DC7098 BI-D1870 Featured

BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC50s are 31 nM, 24 nM, 18 nM, 15 nM, respectively.

501437-28-1
DC7086 BIIB021(CNF2024) Featured

BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.

848695-25-0
DC8263 Bikinin Featured

Bikinin is a strong activator of brassinosteroid (BR) signaling.

188011-69-0
DC7995 Bilastine Featured

Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.

202189-78-4
DC22281 Bilobalide Featured

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba.

33570-04-6
DCAPI1079 Bimatoprost Featured

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

155206-00-1
DC6801 Bindarit Featured

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

130641-38-2
DC7663 BIO Featured

BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor.

667463-62-9
DC8368 BIO-acetoxime Featured

BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO

667463-85-6
DC7603 Bioymifi Featured

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.

1420071-30-2
DC23078 Biperiden Featured

Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker..

514-65-8
DC25079 Biperiden hydrochloride Featured

Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker..

1235-82-1
DC7836 Doramapimod (BIRB-796) Featured

BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

285983-48-4
DC5023 Birinapant (TL32711) Featured

Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP.

1260251-31-7
DC10863 Bis(tributylammonium) difluoromethylenediphosphonate Featured

Bis(tributylammonium) difluoromethylenediphosphonate

81336-71-2
DC10434 Bisantrene Featured

Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases.

78186-34-2
DC10504 BISF-3 Featured

BISF CAS 118511-97-0

118511-97-0
DC10052 Bisindolylmaleimide X(Ro 31-8425) Featured

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).

1241725-89-2
DC8504 Bisindolylmaleimide X HCl Featured

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).

145317-11-9
DC8882 Bitopertin Featured

Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM.

845614-11-1
DC9616 BIX 02565 Featured

BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.

1311367-27-7
DC7374 BIX01294 Featured

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.

935693-62-2
DC5002 BIX02188 (BIX 02188) Featured

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

334949-59-6
DC22637 BKI1369 Featured

BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves.

1951431-22-3
DC5154 BKM120 (NVP-BKM120, Buparlisib) Featured

BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.

944396-07-0
DC20800 BL-918 Featured

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells.

2101517-69-3
DC12391 BL-AD008 Featured

BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK; demonstrates remarkable anti-proliferative activities toward cervical cancer cells and could induce apoptosis by death-receptor and mitochondrial pathways; also sho

DC4196 Bleomycin Sulfate Featured

Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

9041-93-4
DC20801 BLT-1 Featured

BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages.

321673-30-7
DC10530 BLU-285 (Avapritinib) Featured

BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.

1703793-34-3
DC10092 BLU554(Fisogatinib) Featured

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.

1707289-21-1
DC11479 BLU-667 (Pralsetinib) Featured

BLU-667 (Pralsetinib) is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion.

2097132-94-8
DC11152 BLU-782 Featured

BLU-782 (BLU782) is a novel potent, selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 Nm.

2141955-96-4
DC8280 BLU-9931 Featured

BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM).

1538604-68-0
DC8103 BLZ-945 Featured

BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.

953769-46-5
DC9853 BM212 Featured

BM-212 is a potent antimycobacterial agent and MmpL3 inhibitor.

146204-42-4
DC7959 BMH-21 Featured

BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.

896705-16-1
DC7840 BML-190 Featured

BML-190 is an indomethacin morpholinylamide which functions as a selective inverse agonist of the human cannabinoid CB2 receptor.

2854-32-2
DC8660 BML-210(CAY10433) Featured

BML-210 is the novel HDAC inhibitor, and its mechanism of action has not been characterized.

537034-17-6
DC8270 BML-277 Featured

BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM.

516480-79-8
DC9951 AMBMP Featured

AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer c

853220-52-7
DC8453 Talazoparib(BMN-673)tosylate Featured

Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2
DC2008 Talazoparib(BMN-673) Featured

BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.

1207456-01-6
DC23833 SB 4 (Eticovo) Featured

BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes.

100874-08-6
DC22988 BMS-189453 Featured

BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.

166977-43-1
DC8513 BMS-3 Featured

BMS-3 is a potent inhibitor of the LIM kinase. It has IC50's of 5nM and 6 nM for LIMK1 and LIMK2 respectively.

1338247-30-5
DC7375 BMS-303141 Featured

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL).

943962-47-8
DC8457 BMS-309403 Featured

BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E.

300657-03-8
DC5037 BMS-536924 Featured

BMS-536924 is an ATP-competitive IGF-1R inhibitor with IC50 of 100 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.

468740-43-4
DC7897 BMS-582949 HCl Featured

BMS-582949 is a dual action p38 Kinase Inhibitor.

623152-17-0
DC3105 BMS-599626 (AC480) Featured

BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.

714971-09-2
DC7730 Temsavir(BMS-626529) Featured

BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.

701213-36-7
DC9252 BMS-687453 Featured

BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.

1000998-59-3
DC9700 BMS-707035 Featured

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity.

729607-74-3
DC3114 Avagacestat (BMS-708163) Featured

BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.

1146699-66-2
DC3126 BMS754807 Featured

BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.

1001350-96-4
DC9861 BMS-779788(XL-652) Featured

BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.

918348-67-1
DC10494 BMS813160 Featured

BMS-813160 is a dual CCR2/CCR5 chemokine antagonist.

1286279-29-5
DC12670 BMS-817378 free base Featured

BMS-817378 is a prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833.

1174161-69-3
DC20815 BMS-823778 Featured

BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2.

1140898-87-8
DC7154 BMS-833923 (XL-139) Featured

BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhi

1059734-66-5
DC7090 BMS-863233 (XL-413) Featured

BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.

1169562-71-3
DC4175 BMS-911543 Featured

BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, approximately 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively.

1271022-90-2
DC23872 BMS-932481(BMS932481;BMS 932481) Featured

BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.

1263871-36-8
DC21092 BMS-955176 Featured

BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.

1392312-45-6
DC20821 BMS-962212 Featured

BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM.

1430114-34-3
DC10459 BMS-986020 Featured

BMS-986020 is an LPA1 antagonist.

1257213-50-5
DC11923 BMS-986120 Featured

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.

1478712-37-6
DC26073 BMS-986122 Featured

BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells..

313669-88-4
DC11819 BMS-986142 Featured

BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM).

1643368-58-4
DC10609 BMS-986158 Featured

BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.

1800340-40-2
DC12174 Deucravacitinib(BMS986165) Featured

BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

1609392-27-9
DC23532 BMS-986166 Featured

BMS-986166 (BMS986166) is a potent, selective S1P receptor modulator for the treatment of ulcerative colitis..

1883345-06-9
DC23460 BMS986187 Featured

BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor..

684238-37-7
DC12030 BMS-986195 Featured

BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).

1912445-55-6
DC10924 BMS986202 Featured

BMS-986202 is a clinical Tyk2 inhibitor that binds to Tyk2 JH2 with IC50 of 0.19 nM and shows remarkably selectivity over other kinases including Jak family members.

DC10131 BMS-986205(Linrodostat) Featured

BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial

1923833-60-6
DC23998 BMX-IN-1 Featured

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

1431525-23-3
DC7377 BMY 7378 Featured

BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.

21102-95-4
DC7773 BNC-105 Featured

BNC105 is a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy.

945771-74-4
DC22037 Bobcat339 Featured

Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

2280037-51-4
DC23218 BOC-D-FMK Featured

BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.

634911-80-1
DC5077 Boceprevir(EBP 520; SCH 503034 ) Featured

Boceprevir(EBP 520; SCH 503034 ) is useful for Anti HCV.

394730-60-0
DC8073 Bohemine Featured

Bohemine is a synthetic, cell-permeable, cyclin-dependent kinase inhibitor.

189232-42-6
DC1027 Bortezomib (Velcade,MG-341,PS-341) Featured

Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM.

179324-69-7
DC21869 Borussertib Featured

Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor.

1800070-77-2
DC12405 BOS172722 Featured

BOS172722 (BOS-172722) is a potent, selective MPS1 kinase inhibitor with biochemical IC50 of 11 nM, 100-fold selectivity over CDK2.

1578245-44-9
DC5164 Bosutinib (SKI-606) Featured

Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity.

380843-75-4
DC8040 STAT3 Inhibitor XVIII, BP-1-102 Featured

BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor.

1334493-07-0
DC8883 BP897 Featured

BP897 is a partially selective D3 dopamine receptor agonist.

314776-92-6
DC12608 BPN14770 Featured

BPN14770 (BPN-14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively, displays 16-fold less potent against monomeric form of PDE4D lacking the UCR1 dimerization domain (PDE4D2

1606975-12-5
DC8294 BPR1J-097 Featured

BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11±7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM.

1327167-19-0
DC7951 Glutaminase Inhibitor II, BPTES Featured

BPTES is a selective inhibitor of Glutaminase GLS1 (KGA)

314045-39-1
DC10618 BPTU Featured

BPTU is an Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM).

870544-59-5
DC8392 BQ-123 Featured

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

136553-81-6
DC7542 BQ-788 Featured

BQ-788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells); poorly inhibited the binding to ET A receptors in human neuroblastoma cell line SK-N-MC cells (IC(50), 1300 nM).

156161-89-6
DC10515 BQCA Featured

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5.

338747-41-4
DC8202 BQU57 Featured

BQU57 is a potent and selective GTPase Ral Inhibitor.

1637739-82-2
DC7809 BRACO19 trihydrochloride Featured

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

351351-75-2
DC20323 Bractoppin Featured

Bractoppin is a potent, small-molecule chemical inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM; shows no inhibition for recognition of cognate biotinylated phosphopeptides to the TOPBP1 tBRCT 7/8, or GRB2 SH2 proteins; engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket; inhibits substrate recognition detected by Förster resonance energy transfer, and diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51; selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage.

2290527-07-8
DC7775 Bradanicline (TC-5619) Featured

Bradanicline (TC-5619) is an experimental pharmaceutical drugthat acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors.

639489-84-2
DC7718 B-Raf IN 1 Featured

B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).

950736-05-7
DC8921 B-Raf inhibitor 1 Featured

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.

1093100-40-3
DC7008 BRAF inhibitor Featured

BRAF inhibitor is a potent BRAF inhibitor.

918505-61-0
DC12375 Bragsin2 Featured

Bragsin2 is a novel PH-domain-binding inhibitor,inhibiting BRAG2-mediated Arf GTPase activation.

342795-08-8
DC7097 Cebranopadol(GRT-6005) Featured

branopadol(GRT-6005) is a novel first in class compounds with potent agonist activity on ORL-1 (opioid receptor like -1) and the well established mu opioid receptor.

863513-91-1
DC9839 Brassinin Featured

Brassinin is a Inducer of phase II enzymes. Moderate and competitive indoleamine 2,3-dioxygenase inhibitor (Ki = 98 μM). Shows chemopreventive effects in vivo. Orally active.

105748-59-2
DC23100 Brassinolide Featured

Brassinolide is a predominant plant growth modulator that regulate plant cell elongation. It is active against herpes and arena viruses.

72962-43-7
DC12221 BRD 4354 Featured

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

315698-07-8
DC20842 BRD 7389 Featured

BRD 7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively.

376382-11-5
DC20838 BRD0705 Featured

BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM).

2056261-41-5
DC20831 BRD2492 Featured

BRD2492 is a highly potent, selective HDAC1/2 inhibitor (IC50=2/19 nM, respectively) that displays excellent selectivity versus HDAC3 (IC50=2.08 uM, ≥110-fold selectivity) and all other HDAC isoforms, increases caspase-3 activation..

1821669-43-5
DC20832 BRD3308 Featured

BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms.

1550053-02-5
DC7674 BRD4770 Featured

BRD4770 is a selective inhibitor of the histone methyltransferase G9a.

1374601-40-7
DC22711 BRD5814 Featured

BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM.

1953181-29-7
DC8446 BRD7116 Featured

BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.

329059-55-4
DC7936 BRD73954 Featured

BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.

1440209-96-0
DC8409 BRD7552 Featured

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

1137359-47-7
DC20981 Brequinar sodium Featured

Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.

96201-88-6
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