Cat. No. | Product name | CAS No. |
DC5050 |
AGI-5198
Featured
AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. |
1355326-35-0 |
DC7174 |
AGI-6780
Featured
AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM). |
1432660-47-3 |
DC8437 |
AGK2
Featured
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. |
304896-28-4 |
DC7632 |
AHAS inhibitor(BTB06584)
Featured
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). |
219793-45-0 |
DC8735 |
AHU-377 hemicalcium salt
Featured
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
1369773-39-6 |
DC20305 |
AI-10-104
Featured
AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays. |
1881276-00-1 |
DC9402 |
Letermovir(AIC-246)
Featured
AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
917389-32-3 |
DC23900 |
AICAR phosphate
Featured
AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes. |
681006-28-0 |
DC9330 |
AIM-100
Featured
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM IC50 value: 24 nM [3] Target: Ack1 Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 ph |
873305-35-2 |
DC7540 |
SIRT2 Inhibitor II, AK-7
Featured
AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). |
420831-40-9 |
DC23789 |
AK778
Featured
AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. . |
328906-67-8 |
DC20649 |
AKB-9778
Featured
AKB-9778 is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with IC50 of 17 pM. |
|
DC12158 |
AKOS B018304
Featured
AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position. |
6308-22-1 |
DC8458 |
Akt Inhibitor VIII
Featured
Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
612847-09-3 |
DC9677 |
AL 082D06(D-06)
Featured
AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM). |
256925-03-8 |
DC20260 |
AL-335
Featured
AL-335 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase with IE50 values as low as 70 nM. AL-335 is potentially useful for the Treatment of Hepatitis C Infection. AL-335 demonstrated high levels of the nucleoside triphosphate in vitro in primary human hepatocytes and Huh-7 cells as well as in dog liver following a single oral dose. AL-335 was selected for the clinical development where it showed promising results in phase 1 and 2 trials. |
1613589-09-5 |
DC10780 |
ALB-127158(a)
Featured
ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity. |
1173154-32-9 |
DC20174 |
Albiglutide
Featured
Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist). |
782500-75-8 |
DC8723 |
Alda-1
Featured
Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). |
349438-38-6 |
DC20653 |
ALE-0540
Featured
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively. |
234779-34-1 |
DC22492 |
Alexamorelin
Featured
Alexamorelin is a synthetic growth hormone (GH) secretagogue. |
196808-85-2 |
DC12389 |
Alflutinib
Featured
Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.The Alflutinib free base form is not stable, so we make it the mesylate s |
1869057-83-9 |
DC12072 |
Alflutinib (AST2818 mesylate)
Featured
Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.. |
2130958-55-1 |
DC22211 |
ALG1001 (Risuteganib)
Featured
ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis; ALG1001 inhibits an integrin-mediated pathway of the vitreoretinal interface, connecting the posterior aspect of the vitreous with the internal limiting membrane of the retina. In blocking this pathway, ALG-1001 helps to achieve vitreous breakdown and separation from the retina. |
1307293-62-4 |
DCAPI1495 |
Aliskiren Hemifumarate
Featured
Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM. |
173334-58-2 |
DC9338 |
ALK inhibitor 1
Featured
ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase. |
761436-81-1 |
DC9339 |
ALK inhibitor 2
Featured
ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase. |
761438-38-4 |
DC10582 |
Diroximel Fumarete(ALKS-8700)
Featured
ALKS-8700 also known as diroximel fumarate, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. |
1577222-14-0 |
DC8570 |
ALLO-1
Featured
ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM). |
37468-32-9 |
DC21668 |
ALLO-2
Featured
ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. |
1357350-60-7 |
DC10311 |
Allopregnanolone
Featured
Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor. |
516-54-1 |
DCAPI1097 |
Allopurinol Sodium (Aloprim)
Featured
Allopurinol sodium is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol sodium can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2]. |
17795-21-0 |
DC7692 |
Almorexant HCl (Act-078573)
Featured
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
913358-93-7 |
DC8284 |
Almotriptan Malate(PNU180638)
Featured
Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine. |
181183-52-8 |
DC11887 |
Alobresib (GS-5829)
Featured
Alobresib is a novel BET bromodomain inhibitor with antineoplastic activity.. |
1637771-14-2 |
DC11931 |
Alofanib
Featured
Alofanib ((RPT-835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM |
1612888-66-0 |
DC5076 |
Alogliptin Benzoate
Featured
Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabete |
850649-62-6 |
DC10735 |
Alovudine
Featured
Alovudine is a DNA polymerase subunit gamma-1 (POLG) inhibitor, shows promise for treating AML. |
25526-93-6 |
DC9920 |
alpha-Hederin
Featured
alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation. |
27013-91-8 |
DC23079 |
α-mangostin
Featured
Alpha-Mangostin has neuroprotective, anti-cancer, antifungal, neuroprotective, renoprotective, antioxidant and anti-inflammatory activities. |
6147-11-1 |
DC26001 |
Alprenolol
Featured
Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist. |
13655-52-2 |
DCAPI1328 |
Alprostadil(Caverject)
Featured
Alprostadil(Caverject) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. |
745-65-3 |
DC12656 |
Alrestatin
Featured
Alrestatin is an AKR (aldose reductase) inhibitor, which attaches molecules to the active site of the NADP+/enzyme complex in a stacked formation. |
51411-04-2 |
DC8366 |
ALS22335
Featured
ALS-22335 is an anti-virus compound. |
|
DC9838 |
Alsterpaullone
Featured
Alsterpaullone is a potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, that is reported to be the most active Paullone. |
237430-03-4 |
DC8072 |
Altiratinib(DCC-2701)
Featured
Altiratinib is a MET/TIE2/VEGFR2/TRK (A,B,C) kinase inhibitor in Phase 1 clinical development for the treatment of invasive solid tumors including glioblastoma. |
1345847-93-9 |
DC7079 |
Alvelestat (AZD9668)
Featured
Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE. |
848141-11-7 |
DC10209 |
ALW-II-41-27
Featured
ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment. |
1186206-79-0 |
DC23604 |
ALX-5407 hydrochloride
Featured
ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM. |
200006-08-2 |
DC11301 |
ALZ-801
Featured
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. |
1034190-08-3 |
DC11289 |
AM-0466
Featured
AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
1642113-59-4 |
DC8622 |
AM095 free acid
Featured
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
1228690-36-5 |
DC9909 |
AM2099
Featured
AM-2099 is a potent and selective NaV1.7 Inhibitor. |
1443373-17-8 |
DC12230 |
AM211
Featured
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist |
1175526-27-8 |
DC9830 |
AM-2394
Featured
AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. |
1442684-77-6 |
DC8765 |
AM251
Featured
AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM). |
183232-66-8 |
DC8886 |
Iodopravadoline(AM-630)
Featured
AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively. |
164178-33-0 |
DC8623 |
AM966
Featured
AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
1228690-19-4 |
DC10372 |
Amcasertib(BBI503)
Featured
Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases. |
1129403-56-0 |
DC5056 |
AMD3465
Featured
AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
185991-07-5 |
DC10621 |
Amenamevir
Featured
Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. |
841301-32-4 |
DC7356 |
Ametantrone
Featured
Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation. |
64862-96-0 |
DC8618 |
AMG-319
Featured
AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
1608125-21-8 |
DC11239 |
AMG-333
Featured
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
1416799-28-4 |
DC7055 |
AMG517
Featured
AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
659730-32-2 |
DC7867 |
AMG-837
Featured
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
865231-46-5 |
DC9366 |
AMG 900
Featured
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
945595-80-2 |
DC8397 |
AMG 925
Featured
AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell. |
1401033-86-0 |
DC5083 |
Cinacalcet (AMG-073) HCl
Featured
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism. |
364782-34-3 |
DC8514 |
AMG-1
Featured
AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively. |
913376-84-8 |
DC7056 |
AMG-208
Featured
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM. |
1002304-34-8 |
DC8845 |
AMG337
Featured
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. |
1173699-31-4 |
DC10101 |
AMG-3969
Featured
AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM. |
1361224-53-4 |
DC7001 |
AMG-47a
Featured
AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. |
882663-88-9 |
DC20664 |
AMG-548
Featured
AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro |
864249-60-5 |
DC10132 |
AMG9810
Featured
AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
545395-94-6 |
DC8503 |
AMG-Tie2-1
Featured
AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM). |
870223-96-4 |
DC8292 |
AMI-1
Featured
AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor. |
20324-87-2 |
DCAPI1279 |
Aminocaproic acid (Amicar)
Featured
Aminocaproic acid (Amicar)is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders. |
60-32-2 |
DC20178 |
Pyrrolidinedithiocarbamate ammonium;APDC, PDTC
Featured
Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. |
5108-96-3 |
DCAPI1343 |
Amorolfine HCl
Featured
Amorolfine hydrochloride is a antifungal reagent. |
78613-38-4 |
DC10698 |
Amoscanate
Featured
Amoscanate(nithiocyamine) is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,and is also highly active against hookworm |
100990-46-3 |
DC5075 |
BDP-12(Ampalex)
Featured
Ampalex (Ampakine CX516) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
154235-83-3 |
DC11274 |
AMPPD
Featured
AMPPD, 1,2-dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate. |
122341-56-4 |
DC7058 |
Amprenavir
Featured
Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection. |
161814-49-9 |
DC7324 |
Amuvatinib (MP-470)
Featured
Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
850879-09-3 |
DC25088 |
Rivastigmine
Featured
An acetylcholinesterase (AChE) inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase. |
123441-03-2 |
DC11651 |
HLY-78
Featured
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1]. |
854847-61-3 |
DC23227 |
N6-Cyclohexyladenosine
Featured
An adenosine A1 receptor agonist (EC50= 8.2 nM).. |
36396-99-3 |
DC11657 |
PPT(Propyl pyrazole triol )
Featured
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). |
263717-53-9 |
DC24145 |
G-418 disulfate
Featured
An aminoglycoside antibiotic similar in structure to gentamicin B1. |
108321-42-2 |
DC24054 |
Poloxime
Featured
An analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic.. |
17302-61-3 |
DC26076 |
D-Ala2, D-Leu5-Enkephalin
Featured
An angiotensin II analog that is an agonist of AT1 angiotensin receptor.. |
64963-01-5 |
DC22604 |
Anisomycin
Featured
An antibiotic that inhibits eukaryotic protein synthesis by inhibiting peptidyl transferase or the 80S ribosome system. |
22862-76-6 |
DC25077 |
Naphthoquine phosphate
Featured
Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine. |
173531-58-3 |
DC10594 |
Tolcide 2230
Featured
An antimicrobial agent used as a substitute for chlorophenols |
21564-17-0 |
DC22497 |
MMAF-OMe
Featured
MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. |
863971-12-4 |
DC11575 |
E3 Ligand-Linker Conjugate 9
Featured
An E3 ligase ligand-linker conjugate for PROTAC. |
1957236-20-2 |
DC11572 |
E3 Ligand-Linker Conjugate 6
Featured
An E3 ligase ligand-linker conjugate for PROTAC.. |
2022182-57-4 |
DC11573 |
E3 Ligand-Linker Conjugate 7
Featured
An E3 ligase ligand-linker conjugate for PROTAC.. |
2022182-59-6 |
DC11574 |
E3 Ligand-Linker Conjugate 8
Featured
An E3 ligase ligand-linker conjugate for PROTAC.. |
1957235-74-3 |
DC22869 |
E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19)
Featured
An E3 ligase ligand-linker conjugate for PROTAC. |
1799711-24-2 |
DC26084 |
LE-135
Featured
LE135 is a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. |
155877-83-1 |
DC24168 |
(R)-(-)-Ibuprofen
Featured
An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. |
51146-57-7 |
DC23914 |
Thymalfasin GMP grade
Featured
An immunoactive peptide that has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers. |
62304-98-7 |
DC1001 |
FK-506 (Tacrolimus)
Featured
An immunosuppressive agent and macrolide antibiotic. |
104987-11-3 |
DC22995 |
IRES-J007
Featured
IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
155514-72-0 |
DC6311 |
Pomalidomide
Featured
An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects. |
19171-19-8 |
DC24177 |
Mitiglinide calcium hydrate
Featured
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
207844-01-7 |
DC22612 |
Afatinib
Featured
An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
850140-72-6 |
DC11640 |
PK-11195
Featured
PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively). |
85532-75-8 |
DC11911 |
Rovazolac
Featured
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. |
1454288-88-0 |
DC24069 |
CI-947
Featured
An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.. |
96392-15-3 |
DC23019 |
PACMA 31
Featured
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI. |
1401089-31-3 |
DC21242 |
LM11A-31 dihydrochloride
Featured
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
1243259-19-9 |
DC24008 |
Eperezolid
Featured
An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo.. |
165800-04-4 |
DC20418 |
InS3-54
Featured
An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
328998-92-1 |
DC7815 |
Crisaborole(AN-2728)
Featured
AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. |
906673-24-3 |
DC9827 |
AN3365(Epetraborole)
Featured
AN3365 is a first-in-class antibiotic that demonstrates potent activity across a wide spectrum of Gram-negative bacteria, including those resistant to many other antibiotics. |
1234563-16-6 |
DC8029 |
ANA-12
Featured
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice. |
219766-25-3 |
DC8322 |
Anacardic Acid
Featured
Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively. |
16611-84-0 |
DC7804 |
Anacetrapib(MK0859)
Featured
Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
875446-37-0 |
DC7357 |
Anamorelin
Featured
Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
249921-19-5 |
DCAPI1425 |
Anastrozole
Featured
Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
120511-73-1 |
DC11649 |
Jamaicin (AnCoA4)
Featured
AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
24211-36-7 |
DC8122 |
Andarine (GTX-007,S-4)
Featured
Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist. |
401900-40-1 |
DCAPI1490 |
Anidulafungin
Featured
Anidulafungin |
166663-25-8 |
DC10168 |
Anle138b
Featured
Anle138b is a novel oligomer modulator. |
882697-00-9 |
DC8802 |
Maytansinol(Ansamitocin P-0)
Featured
Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Target: Microtubule/Tubulin in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. |
57103-68-1 |
DC8241 |
Ansamitocin P-3
Featured
Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. |
66584-72-3 |
DC20670 |
ANT431
Featured
ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
1639972-90-9 |
DC20078 |
AP1867
Featured
AP1867 is a synthetic FKBP12F36V-directed ligand. |
195514-23-9 |
DC22207 |
AP1903
Featured
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM. |
195514-63-7 |
DC1020 |
Ponatinib (AP24534)
Featured
AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
943319-70-8 |
DC5198 |
ALK-IN-1 (Brigatinib analog)
Featured
ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1. |
1197958-12-5 |
DC12636 |
Apararenone
Featured
Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.. |
945966-46-1 |
DC4101 |
Apatinib Mesylate
Featured
Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
1218779-75-9 |
DC8465 |
Apatinib (free base)
Featured
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
811803-05-1 |
DC20310 |
Apcin
Featured
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
300815-04-7 |
DC8804 |
APD597(JNJ-38431055)
Featured
APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. |
897732-93-3 |
DC21448 |
Apicidin
Featured
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
183506-66-3 |
DC8275 |
Apilimod
Featured
Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
541550-19-0 |
DC8276 |
Apilimod mesylate
Featured
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
870087-36-8 |
DC5114 |
Apixaban (BMS 562247-01)
Featured
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
503612-47-3 |
DC23522 |
Aplaviroc HCl
Featured
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
461023-63-2 |
DC6901 |
Daporinad(FK866,APO866)
Featured
APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. |
658084-64-1 |
DC23901 |
R-(-)-Apomorphine
Featured
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
41372-20-7 |
DC2066 |
Apoptosis Activator 2
Featured
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. |
79183-19-0 |
DC10122 |
Apoptozole
Featured
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
1054543-47-3 |
DC7063 |
Apremilast
Featured
Apremilast(CC10004) is a novel small molecule inhibitor of PDE4 with an IC50 value of 74 nM. |
608141-41-9 |
DC11513 |
Aprocitentan (ACT-132577)
Featured
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting. |
1103522-45-7 |
DC10048 |
APS-2-79
Featured
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
2002381-25-9 |
DC9808 |
APS-2-79 hydrochloride
Featured
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
2002381-31-7 |
DC9809 |
APS-3-77 HCl
Featured
APS-3-77 is the negative binder of KSR2. |
|
DC20672 |
APX001A
Featured
APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
936339-60-5 |
DC11809 |
APX-115
Featured
APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
1270084-92-8 |
DC7922 |
APY0201
Featured
APY0201 is a potent, highly selective PIKfyve kinase inhibitor. |
1232221-74-7 |
DC7358 |
APY29
Featured
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
1216665-49-4 |
DC8764 |
AR 231453
Featured
AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent. |
733750-99-7 |
DC10135 |
AR-7
Featured
AR7 is a retinoic acid receptor α (RARα) antagonist. |
80306-38-3 |
DC22493 |
ARA-290(Cibinetide)
Featured
ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative. |
1208243-50-8 |
DC8888 |
Ara-G
Featured
Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. |
38819-10-2 |
DCAPI1051 |
Arbidol HCl (Umifenovir)
Featured
Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc |
131707-23-8 |
DC20265 |
Arctigenin
Featured
Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, |
7770-78-7 |
DC9659 |
Arctiin(NSC 315527)
Featured
Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. |
20362-31-6 |
DCAPI1329 |
Argatroban
Featured
Argatroban |
74863-84-6 |
DC8841 |
Argatroban monohydrate
Featured
Argatroban monohydrate is a direct, selective thrombin inhibitor. |
141396-28-3 |
DC9487 |
Arg-Gly-Asp-Ser
Featured
Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS |
91037-65-9 |
DC9645 |
(+)-Arglabin
Featured
Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound. |
84692-91-1 |
DC10110 |
ARM390 Hydrochloride
Featured
ARM390 is a non-peptidic, low-internalizing δ-selective opioid receptor agonist. |
209808-47-9 |
DC9345 |
ARN2966(2-PMAP)
Featured
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. |
102212-26-0 |
DC10824 |
ARN-3236
Featured
ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. |
1613710-01-2 |
DC7064 |
Apalutamide(ARN509)
Featured
ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. |
956104-40-8 |
DC9972 |
ARQ-092(Miransertib)
Featured
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
1313881-70-7 |
DC7820 |
ARQ 621
Featured
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. |
1095253-39-6 |
DC10975 |
ARQ-531
Featured
ARQ-531 is a potent, reversible, orally available inhibitor of both wild type and C481S-mutant BTK kinase with IC50 of 0.85 and 0.39 nM, |
2095393-15-8 |
DC8181 |
Filanesib(ARRY-520)
Featured
ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. |
885060-09-3 |
DC10738 |
ARS-1323
Featured
ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
1698024-73-5 |
DC10725 |
ARS-1620
Featured
ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C. |
1698055-85-4 |
DC12031 |
ARS-1630
Featured
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
1698055-86-5 |
DC8816 |
ARS-853
Featured
ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
1629268-00-3 |
DC10334 |
ARV-771
Featured
ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively. |
1949837-12-0 |
DC12024 |
ARV-825
Featured
ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. |
|
DC8256 |
AS 602801(Bentamapimod)
Featured
AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK. |
848344-36-5 |
DC9840 |
AS-8351
Featured
AS 8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409. |
796-42-9 |
DC22001 |
AS-1269574
Featured
AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays. |
330981-72-1 |
DC11420 |
AS-1517499
Featured
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. |
919486-40-1 |
DC10086 |
AS1842856
Featured
AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM. |
836620-48-5 |
DC3112 |
AS-252424
Featured
AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM. |
900515-16-4 |
DC20035 |
AS2717638
Featured
AS2717638 is an oral active lysophosphatidic acid receptor 5 (LPA5) antagonist in rodents. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia. |
2148339-28-8 |
DC11460 |
AS604850
Featured
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. |
648449-76-7 |
DC11407 |
Asapiprant(BGE-175)
Featured
Asapiprant (BGE-175) is a potent and specific antagonist of human PGD2/PTGDR signaling with Ki of 0.44 nM. BGE-175 is currently in a Phase 2 clinical trial to test whether it can prevent disease progression and mortality in older patients hospitalized wit |
932372-01-5 |
DC20622 |
Asciminib
Featured
Asciminib (ABL-001) is a potent and selective allosteric ABL1 inhibitor with IC50 of 0.25 nM in BCR–ABL1-transformed BaF3 cells. |
1492952-76-7 |
DC1049 |
Ascomycin (Immunomycin,FK-520)
Featured
Ascomycin is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities. |
104987-12-4 |
DCAPI1060 |
L-Ascorbyl 6-palmitate
Featured
Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C. |
137-66-6 |
DC10704 |
Asimadoline (EMD-61753)
Featured
Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist. |
153205-46-0 |
DC10781 |
ASK1-IN-1
Featured
ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4. |
1262041-49-5 |
DC21100 |
Gusacitinib (ASN-002)
Featured
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays. |
1425381-60-7 |
DC10558 |
ASP 7663
Featured
ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). |
1190217-35-6 |
DC7359 |
Asp-3026
Featured
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. |
1097917-15-1 |