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Cat. No. Product name CAS No.
DC5050 AGI-5198 Featured

AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.

1355326-35-0
DC7174 AGI-6780 Featured

AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM).

1432660-47-3
DC8437 AGK2 Featured

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.

304896-28-4
DC7632 AHAS inhibitor(BTB06584) Featured

AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).

219793-45-0
DC8735 AHU-377 hemicalcium salt Featured

AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM.

1369773-39-6
DC20305 AI-10-104 Featured

AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.

1881276-00-1
DC9402 Letermovir(AIC-246) Featured

AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.

917389-32-3
DC23900 AICAR phosphate Featured

AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.

681006-28-0
DC9330 AIM-100 Featured

AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM IC50 value: 24 nM [3] Target: Ack1 Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 ph

873305-35-2
DC7540 SIRT2 Inhibitor II, AK-7 Featured

AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).

420831-40-9
DC23789 AK778 Featured

AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. .

328906-67-8
DC20649 AKB-9778 Featured

AKB-9778 is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with IC50 of 17 pM.

DC12158 AKOS B018304 Featured

AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position.

6308-22-1
DC8458 Akt Inhibitor VIII Featured

Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).

612847-09-3
DC9677 AL 082D06(D-06) Featured

AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM).

256925-03-8
DC20260 AL-335 Featured

AL-335 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase with IE50 values as low as 70 nM. AL-335 is potentially useful for the Treatment of Hepatitis C Infection. AL-335 demonstrated high levels of the nucleoside triphosphate in vitro in primary human hepatocytes and Huh-7 cells as well as in dog liver following a single oral dose. AL-335 was selected for the clinical development where it showed promising results in phase 1 and 2 trials.

1613589-09-5
DC10780 ALB-127158(a) Featured

ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity.

1173154-32-9
DC20174 Albiglutide Featured

Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist).

782500-75-8
DC8723 Alda-1 Featured

Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).

349438-38-6
DC20653 ALE-0540 Featured

ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.

234779-34-1
DC22492 Alexamorelin Featured

Alexamorelin is a synthetic growth hormone (GH) secretagogue.

196808-85-2
DC12389 Alflutinib Featured

Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.The Alflutinib free base form is not stable, so we make it the mesylate s

1869057-83-9
DC12072 Alflutinib (AST2818 mesylate) Featured

Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation..

2130958-55-1
DC22211 ALG1001 (Risuteganib) Featured

ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis; ALG1001 inhibits an integrin-mediated pathway of the vitreoretinal interface, connecting the posterior aspect of the vitreous with the internal limiting membrane of the retina. In blocking this pathway, ALG-1001 helps to achieve vitreous breakdown and separation from the retina.

1307293-62-4
DCAPI1495 Aliskiren Hemifumarate Featured

Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.

173334-58-2
DC9338 ALK inhibitor 1 Featured

ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase.

761436-81-1
DC9339 ALK inhibitor 2 Featured

ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.

761438-38-4
DC10582 Diroximel Fumarete(ALKS-8700) Featured

ALKS-8700 also known as diroximel fumarate, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body.

1577222-14-0
DC8570 ALLO-1 Featured

ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).

37468-32-9
DC21668 ALLO-2 Featured

ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

1357350-60-7
DC10311 Allopregnanolone Featured

Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor.

516-54-1
DCAPI1097 Allopurinol Sodium (Aloprim) Featured

Allopurinol sodium is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol sodium can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

17795-21-0
DC7692 Almorexant HCl (Act-078573) Featured

Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.

913358-93-7
DC8284 Almotriptan Malate(PNU180638) Featured

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.

181183-52-8
DC11887 Alobresib (GS-5829) Featured

Alobresib is a novel BET bromodomain inhibitor with antineoplastic activity..

1637771-14-2
DC11931 Alofanib Featured

Alofanib ((RPT-835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM

1612888-66-0
DC5076 Alogliptin Benzoate Featured

Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabete

850649-62-6
DC10735 Alovudine Featured

Alovudine is a DNA polymerase subunit gamma-1 (POLG) inhibitor, shows promise for treating AML.

25526-93-6
DC9920 alpha-Hederin Featured

alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation.

27013-91-8
DC23079 α-mangostin Featured

Alpha-Mangostin has neuroprotective, anti-cancer, antifungal, neuroprotective, renoprotective, antioxidant and anti-inflammatory activities.

6147-11-1
DC26001 Alprenolol Featured

Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist.

13655-52-2
DCAPI1328 Alprostadil(Caverject) Featured

Alprostadil(Caverject) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.

745-65-3
DC12656 Alrestatin Featured

Alrestatin is an AKR (aldose reductase) inhibitor, which attaches molecules to the active site of the NADP+/enzyme complex in a stacked formation.

51411-04-2
DC8366 ALS22335 Featured

ALS-22335 is an anti-virus compound.

DC9838 Alsterpaullone Featured

Alsterpaullone is a potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, that is reported to be the most active Paullone.

237430-03-4
DC8072 Altiratinib(DCC-2701) Featured

Altiratinib is a MET/TIE2/VEGFR2/TRK (A,B,C) kinase inhibitor in Phase 1 clinical development for the treatment of invasive solid tumors including glioblastoma.

1345847-93-9
DC7079 Alvelestat (AZD9668) Featured

Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE.

848141-11-7
DC10209 ALW-II-41-27 Featured

ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment.

1186206-79-0
DC23604 ALX-5407 hydrochloride Featured

ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

200006-08-2
DC11301 ALZ-801 Featured

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.

1034190-08-3
DC11289 AM-0466 Featured

AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.).

1642113-59-4
DC8622 AM095 free acid Featured

AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.

1228690-36-5
DC9909 AM2099 Featured

AM-2099 is a potent and selective NaV1.7 Inhibitor.

1443373-17-8
DC12230 AM211 Featured

AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist

1175526-27-8
DC9830 AM-2394 Featured

AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.

1442684-77-6
DC8765 AM251 Featured

AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors; also potent GPR55 agonist (EC50 = 39 nM).

183232-66-8
DC8886 Iodopravadoline(AM-630) Featured

AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively.

164178-33-0
DC8623 AM966 Featured

AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors.

1228690-19-4
DC10372 Amcasertib(BBI503) Featured

Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases.

1129403-56-0
DC5056 AMD3465 Featured

AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

185991-07-5
DC10621 Amenamevir Featured

Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor.

841301-32-4
DC7356 Ametantrone Featured

Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation.

64862-96-0
DC8618 AMG-319 Featured

AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells

1608125-21-8
DC11239 AMG-333 Featured

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

1416799-28-4
DC7055 AMG517 Featured

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

659730-32-2
DC7867 AMG-837 Featured

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

865231-46-5
DC9366 AMG 900 Featured

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.

945595-80-2
DC8397 AMG 925 Featured

AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.

1401033-86-0
DC5083 Cinacalcet (AMG-073) HCl Featured

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism.

364782-34-3
DC8514 AMG-1 Featured

AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively.

913376-84-8
DC7056 AMG-208 Featured

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.

1002304-34-8
DC8845 AMG337 Featured

AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.

1173699-31-4
DC10101 AMG-3969 Featured

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM.

1361224-53-4
DC7001 AMG-47a Featured

AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.

882663-88-9
DC20664 AMG-548 Featured

AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro

864249-60-5
DC10132 AMG9810 Featured

AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM).

545395-94-6
DC8503 AMG-Tie2-1 Featured

AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM).

870223-96-4
DC8292 AMI-1 Featured

AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor.

20324-87-2
DCAPI1279 Aminocaproic acid (Amicar) Featured

Aminocaproic acid (Amicar)is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

60-32-2
DC20178 Pyrrolidinedithiocarbamate ammonium;APDC, PDTC Featured

Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

5108-96-3
DCAPI1343 Amorolfine HCl Featured

Amorolfine hydrochloride is a antifungal reagent.

78613-38-4
DC10698 Amoscanate Featured

Amoscanate(nithiocyamine) is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,and is also highly active against hookworm

100990-46-3
DC5075 BDP-12(Ampalex) Featured

Ampalex (Ampakine CX516) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

154235-83-3
DC11274 AMPPD Featured

AMPPD, 1,2-dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.

122341-56-4
DC7058 Amprenavir Featured

Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.

161814-49-9
DC7324 Amuvatinib (MP-470) Featured

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.

850879-09-3
DC25088 Rivastigmine Featured

An acetylcholinesterase (AChE) inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.

123441-03-2
DC11651 HLY-78 Featured

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

854847-61-3
DC23227 N6-Cyclohexyladenosine Featured

An adenosine A1 receptor agonist (EC50= 8.2 nM)..

36396-99-3
DC11657 PPT(Propyl pyrazole triol ) Featured

Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

263717-53-9
DC24145 G-418 disulfate Featured

An aminoglycoside antibiotic similar in structure to gentamicin B1.

108321-42-2
DC24054 Poloxime Featured

An analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic..

17302-61-3
DC26076 D-Ala2, D-Leu5-Enkephalin Featured

An angiotensin II analog that is an agonist of AT1 angiotensin receptor..

64963-01-5
DC22604 Anisomycin Featured

An antibiotic that inhibits eukaryotic protein synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

22862-76-6
DC25077 Naphthoquine phosphate Featured

Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine.

173531-58-3
DC10594 Tolcide 2230 Featured

An antimicrobial agent used as a substitute for chlorophenols

21564-17-0
DC22497 MMAF-OMe Featured

MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

863971-12-4
DC11575 E3 Ligand-Linker Conjugate 9 Featured

An E3 ligase ligand-linker conjugate for PROTAC.

1957236-20-2
DC11572 E3 Ligand-Linker Conjugate 6 Featured

An E3 ligase ligand-linker conjugate for PROTAC..

2022182-57-4
DC11573 E3 Ligand-Linker Conjugate 7 Featured

An E3 ligase ligand-linker conjugate for PROTAC..

2022182-59-6
DC11574 E3 Ligand-Linker Conjugate 8 Featured

An E3 ligase ligand-linker conjugate for PROTAC..

1957235-74-3
DC22869 E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19) Featured

An E3 ligase ligand-linker conjugate for PROTAC.

1799711-24-2
DC26084 LE-135 Featured

LE135 is a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.

155877-83-1
DC24168 (R)-(-)-Ibuprofen Featured

An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.

51146-57-7
DC23914 Thymalfasin GMP grade Featured

An immunoactive peptide that has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers.

62304-98-7
DC1001 FK-506 (Tacrolimus) Featured

An immunosuppressive agent and macrolide antibiotic.

104987-11-3
DC22995 IRES-J007 Featured

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

155514-72-0
DC6311 Pomalidomide Featured

An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects.

19171-19-8
DC24177 Mitiglinide calcium hydrate Featured

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.

207844-01-7
DC22612 Afatinib Featured

An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.

850140-72-6
DC11640 PK-11195 Featured

PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively).

85532-75-8
DC11911 Rovazolac Featured

Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

1454288-88-0
DC24069 CI-947 Featured

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo..

96392-15-3
DC23019 PACMA 31 Featured

An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.

1401089-31-3
DC21242 LM11A-31 dihydrochloride Featured

An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.

1243259-19-9
DC24008 Eperezolid Featured

An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo..

165800-04-4
DC20418 InS3-54 Featured

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.

328998-92-1
DC7815 Crisaborole(AN-2728) Featured

AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

906673-24-3
DC9827 AN3365(Epetraborole) Featured

AN3365 is a first-in-class antibiotic that demonstrates potent activity across a wide spectrum of Gram-negative bacteria, including those resistant to many other antibiotics.

1234563-16-6
DC8029 ANA-12 Featured

ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.

219766-25-3
DC8322 Anacardic Acid Featured

Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.

16611-84-0
DC7804 Anacetrapib(MK0859) Featured

Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.

875446-37-0
DC7357 Anamorelin Featured

Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.

249921-19-5
DCAPI1425 Anastrozole Featured

Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.

120511-73-1
DC11649 Jamaicin (AnCoA4) Featured

AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

24211-36-7
DC8122 Andarine (GTX-007,S-4) Featured

Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist.

401900-40-1
DCAPI1490 Anidulafungin Featured

Anidulafungin

166663-25-8
DC10168 Anle138b Featured

Anle138b is a novel oligomer modulator.

882697-00-9
DC8802 Maytansinol(Ansamitocin P-0) Featured

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Target: Microtubule/Tubulin in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.

57103-68-1
DC8241 Ansamitocin P-3 Featured

Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

66584-72-3
DC20670 ANT431 Featured

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

1639972-90-9
DC20078 AP1867 Featured

AP1867 is a synthetic FKBP12F36V-directed ligand.

195514-23-9
DC22207 AP1903 Featured

AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.

195514-63-7
DC1020 Ponatinib (AP24534) Featured

AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

943319-70-8
DC5198 ALK-IN-1 (Brigatinib analog) Featured

ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

1197958-12-5
DC12636 Apararenone Featured

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis..

945966-46-1
DC4101 Apatinib Mesylate Featured

Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM.

1218779-75-9
DC8465 Apatinib (free base) Featured

Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities.

811803-05-1
DC20310 Apcin Featured

Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.

300815-04-7
DC8804 APD597(JNJ-38431055) Featured

APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.

897732-93-3
DC21448 Apicidin Featured

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay.

183506-66-3
DC8275 Apilimod Featured

Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.

541550-19-0
DC8276 Apilimod mesylate Featured

Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.

870087-36-8
DC5114 Apixaban (BMS 562247-01) Featured

Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

503612-47-3
DC23522 Aplaviroc HCl Featured

Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

461023-63-2
DC6901 Daporinad(FK866,APO866) Featured

APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM.

658084-64-1
DC23901 R-(-)-Apomorphine Featured

Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes..

41372-20-7
DC2066 Apoptosis Activator 2 Featured

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

79183-19-0
DC10122 Apoptozole Featured

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity.

1054543-47-3
DC7063 Apremilast Featured

Apremilast(CC10004) is a novel small molecule inhibitor of PDE4 with an IC50 value of 74 nM.

608141-41-9
DC11513 Aprocitentan (ACT-132577) Featured

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.

1103522-45-7
DC10048 APS-2-79 Featured

APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM

2002381-25-9
DC9808 APS-2-79 hydrochloride Featured

APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM

2002381-31-7
DC9809 APS-3-77 HCl Featured

APS-3-77 is the negative binder of KSR2.

DC20672 APX001A Featured

APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris).

936339-60-5
DC11809 APX-115 Featured

APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

1270084-92-8
DC7922 APY0201 Featured

APY0201 is a potent, highly selective PIKfyve kinase inhibitor.

1232221-74-7
DC7358 APY29 Featured

APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

1216665-49-4
DC8764 AR 231453 Featured

AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent.

733750-99-7
DC10135 AR-7 Featured

AR7 is a retinoic acid receptor α (RARα) antagonist.

80306-38-3
DC22493 ARA-290(Cibinetide) Featured

ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative.

1208243-50-8
DC8888 Ara-G Featured

Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

38819-10-2
DCAPI1051 Arbidol HCl (Umifenovir) Featured

Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc

131707-23-8
DC20265 Arctigenin Featured

Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory,

7770-78-7
DC9659 Arctiin(NSC 315527) Featured

Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.

20362-31-6
DCAPI1329 Argatroban Featured

Argatroban

74863-84-6
DC8841 Argatroban monohydrate Featured

Argatroban monohydrate is a direct, selective thrombin inhibitor.

141396-28-3
DC9487 Arg-Gly-Asp-Ser Featured

Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS

91037-65-9
DC9645 (+)-Arglabin Featured

Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.

84692-91-1
DC10110 ARM390 Hydrochloride Featured

ARM390 is a non-peptidic, low-internalizing δ-selective opioid receptor agonist.

209808-47-9
DC9345 ARN2966(2-PMAP) Featured

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.

102212-26-0
DC10824 ARN-3236 Featured

ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L.

1613710-01-2
DC7064 Apalutamide(ARN509) Featured

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment.

956104-40-8
DC9972 ARQ-092(Miransertib) Featured

ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).

1313881-70-7
DC7820 ARQ 621 Featured

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

1095253-39-6
DC10975 ARQ-531 Featured

ARQ-531 is a potent, reversible, orally available inhibitor of both wild type and C481S-mutant BTK kinase with IC50 of 0.85 and 0.39 nM,

2095393-15-8
DC8181 Filanesib(ARRY-520) Featured

ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

885060-09-3
DC10738 ARS-1323 Featured

ARS-1323 is a novel inhibitor of mutant K-ras G12C.

1698024-73-5
DC10725 ARS-1620 Featured

ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C.

1698055-85-4
DC12031 ARS-1630 Featured

ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound..

1698055-86-5
DC8816 ARS-853 Featured

ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation.

1629268-00-3
DC10334 ARV-771 Featured

ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively.

1949837-12-0
DC12024 ARV-825 Featured

ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.

DC8256 AS 602801(Bentamapimod) Featured

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.

848344-36-5
DC9840 AS-8351 Featured

AS 8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409.

796-42-9
DC22001 AS-1269574 Featured

AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays.

330981-72-1
DC11420 AS-1517499 Featured

AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.

919486-40-1
DC10086 AS1842856 Featured

AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM.

836620-48-5
DC3112 AS-252424 Featured

AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM.

900515-16-4
DC20035 AS2717638 Featured

AS2717638 is an oral active lysophosphatidic acid receptor 5 (LPA5) antagonist in rodents. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.

2148339-28-8
DC11460 AS604850 Featured

AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.

648449-76-7
DC11407 Asapiprant(BGE-175) Featured

Asapiprant (BGE-175) is a potent and specific antagonist of human PGD2/PTGDR signaling with Ki of 0.44 nM. BGE-175 is currently in a Phase 2 clinical trial to test whether it can prevent disease progression and mortality in older patients hospitalized wit

932372-01-5
DC20622 Asciminib Featured

Asciminib (ABL-001) is a potent and selective allosteric ABL1 inhibitor with IC50 of 0.25 nM in BCR–ABL1-transformed BaF3 cells.

1492952-76-7
DC1049 Ascomycin (Immunomycin,FK-520) Featured

Ascomycin is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities.

104987-12-4
DCAPI1060 L-Ascorbyl 6-palmitate Featured

Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.

137-66-6
DC10704 Asimadoline (EMD-61753) Featured

Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist.

153205-46-0
DC10781 ASK1-IN-1 Featured

ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.

1262041-49-5
DC21100 Gusacitinib (ASN-002) Featured

ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays.

1425381-60-7
DC10558 ASP 7663 Featured

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat).

1190217-35-6
DC7359 Asp-3026 Featured

ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM.

1097917-15-1
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